nd This book stems from the 2 Parkinson's Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders," held on August 6-7,1999 at the University ofUlm Medical School in Ulm at the Danube, Germany. The symposium wasalso asatellite ofthejointmeetingofthe InternationalSocietyfor Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) that followed immediately afterwards in Berlin. The specific topic, neurotoxic factors in Parkinson's disease (PD), was chosen in light of accumulating neurobiological and epidemiological evidence indicating that the causes of this second most common neurodegenerative disorder, and possibly of related conditions such as multiple systems atrophy, in some manner involve environ mental (xenobiotic) and even endogenous toxic agents. This volume brings together much of that neurobiological evidence; and in epidemiology, several recent major studies ofPD - for example, a study of20,000 twins published in the Journal of the American Medical Association in 1999 - conclude that environmental and life style than genetics, appear to be critical in the idiopathic disease. However, factors, rather the precise roles of neurotoxic factors in the pathogenesis of PD and related basal ganglia disorders remain uncertain, despite the cascade of research resulting from the discovery of the prototype MPTP in the early 1980's, and frankly, we have been surprised by the paucity of concentrated attention on specific environmental agents other than MPTP."

nd This book stems from the 2 Parkinson's Disease Symposium on "Neurotoxic Factors in Parkinsons disease and related disorders", held on August 6-7,1999 at the University ofUlm Medical School in Ulm at the Danube, Germany. The symposium wasalso asatellite ofthejointmeetingofthe InternationalSocietyfor Neurochemistry (ISN) and the European Society for Neurochemistry (ESN) that followed immediately afterwards in Berlin. The specific topic, neurotoxic factors in Parkinson's disease (PD), was chosen in light of accumulating neurobiological and epidemiological evidence indicating that the causes of this second most common neurodegenerative disorder, and possibly of related conditions such as multiple systems atrophy, in some manner involve environ- mental (xenobiotic) and even endogenous toxic agents. This volume brings together much of that neurobiological evidence; and in epidemiology, several recent major studies ofPD - for example, a study of20,000 twins published in the Journal of the American Medical Association in 1999 - conclude that environmental and life style than genetics, appear to be critical in the idiopathic disease. However, factors, rather the precise roles of neurotoxic factors in the pathogenesis of PD and related basal ganglia disorders remain uncertain, despite the cascade of research resulting from the discovery of the prototype MPTP in the early 1980's, and frankly, we have been surprised by the paucity of concentrated attention on specific environmental agents other than MPTP.

Dieses Buch vermittelt einen kompetenten und facherubergreifenden Uberblick uber das aktuelle Wissen auf dem Gebiet der Parkinson-Krankheit. Es ist im deutschsprachigen Raum das einzige Buch, das umfassend neurobiologische Grundlagen, experimentelle Modelle, Klinik und Therapie der Parkinson-Krankheit beschreibt und einen kompakten Uberblick zur Pharmakologie und den Wirkmechanismen der Anti-Parkinson-Medikamente gibt. Das Buch besticht durch seine klare Systematik und die komprimierte Darstellung mit vielen Tabellen, Schemata und Abbildungen. Das Buch ist Lehrbuch, Nachschlagewerk und Leitfaden fur Studenten, Arzte und Wissenschaftler. Daruber hinaus werden auch dem interessierten Patienten und Laien wichtige Informationen geboten.

Neu in der 4. Auflage: Alle neuen Medikamente; Neueste Entwicklungen in der Genetik, Pathogenese- und Therapieforschung; Aktuelle Ubersicht uber Modelle der Parkinson-Krankheit; Gegenwartiger Stand der klinischen Studien zur symptomatischen Therapie und Neuroprotektion."

Dieses Buch soll in der taglichen Praxis bei der Behandlung von Patienten mit Parkinson-Syndromen als Ratgeber und Nachschlagewerk dienen. Esgibt einen Uberblick uber die klinischen Erscheinungsformen und Diagnosekriterien der verschiedenen Erkrankungen sowie deren neuropathologische Veranderungen. Dabei stehen neben den theoretischen Hintergrunden die praktisch-klinischen Aspekte besonders im Vordergrund.