The volume LNAI 13054 constitutes the refereed proceedings of the 22th Annual Conference Towards Autonomous Robotic Systems, TAROS 2021, held in Lincoln, UK, in September 2021.*The 45 full papers were carefully reviewed and selected from 66 submissions. Organized in the topical sections "Algorithms" and "Systems", they discuss significant findings and advances in the following areas: artificial intelligence; mechatronics; image processing and computer vision; special purpose and application-based systems; user interfaces and human computer interaction. * The conference was held virtually due to the COVID-19 pandemic.