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This book provides a state-of-the-art update, as well as
perspectives on future directions of research and clinical
applications in the implementation of biomechanical and biophysical
experimental, theoretical and computational models which are
relevant to military medicine. Such experimental and modeling
efforts are helpful, on the one hand, in understanding the
aetiology, pathophysiology and dynamics of injury development and
on the other hand in guiding the development of better equipment
and protective gear or devices that should ultimately reduce the
prevalence and incidence of injuries or lessen their hazardous
effects. The book is useful for military-oriented biomedical
engineers and medical physicists, as well as for military
physiologists and other medical specialists who are interested in
the science and technology implemented in modern investigations of
military related injuries.
This edited volume collects the research results presented at the
14th International Symposium on Computer Methods in Biomechanics
and Biomedical Engineering, Tel Aviv, Israel, 2016. The topical
focus includes, but is not limited to, cardiovascular fluid
dynamics, computer modeling of tissue engineering, skin and spine
biomechanics, as well as biomedical image analysis and processing.
The target audience primarily comprises research experts in the
field of bioengineering, but the book may also be beneficial for
graduate students alike.
This volume describes the state-of-knowledge in the study of the
relationships between mechanical loading states in tissues and
common pathophysiologies related to increase in mass of adipose
tissues and/or hyperglycemia which eventually lead to obesity,
diabetes, insulin resistance, hyperlipidemia, metabolic
inflammations, certain types of cancer and other related diseases.
There appears to be an interaction between the loading states in
tissues and cells and these chronic conditions, as well as with
factors such as age, gender and genetics of the individual.
Bioengineering has made key contributions to this research field in
providing technologies for cell biomechanics experimentation,
microscopy and image processing, tissue engineering and
multi-scale, multi-physics computational modeling. Topics at the
frontier of this field of study include: the continuous monitoring
of cell growth, proliferation and differentiation in response to
mechanical factors such as stiffness of the extracellular matrix
(ECM) and mechanical loads transferred through the ECM;
mechanically-activated signaling pathways and molecular mechanisms;
effects of different loading regimes and mechanical environments on
differentiation fates of mesenchymal stem cells (MSCs) into
myogenic and osteogenic versus adipogenic lineages; the
interactions between nutrition and mechanotransduction; cell
morphology, focal adhesion patterns and cytoskeletal remodeling
changes in adipogenesis; activation of receptors related to
diabetes by mechanical forces; brown and white adipose plasticity
and its regulation by mechanical factors.
This book provides a state-of-the-art update, as well as
perspectives on future directions of research and clinical
applications in the implementation of biomechanical and biophysical
experimental, theoretical and computational models which are
relevant to military medicine. Such experimental and modeling
efforts are helpful, on the one hand, in understanding the
aetiology, pathophysiology and dynamics of injury development and
on the other hand in guiding the development of better equipment
and protective gear or devices that should ultimately reduce the
prevalence and incidence of injuries or lessen their hazardous
effects. The book is useful for military-oriented biomedical
engineers and medical physicists, as well as for military
physiologists and other medical specialists who are interested in
the science and technology implemented in modern investigations of
military related injuries.
This book reviews the state-of-the-art in multiscale computer
modeling, in terms of both accomplishments and challenges. The
information in the book is particularly useful for biomedical
engineers, medical physicists and researchers in systems biology,
mathematical biology, micro-biomechanics and biomaterials who are
interested in how to bridge between traditional biomedical
engineering work at the organ and tissue scales, and the newer
arenas of cellular and molecular bioengineering.
This book reviews the frontier of research and clinical
applications of Patient Specific Modeling, and provides a
state-of-the-art update as well as perspectives on future
directions in this exciting field. The book is useful for medical
physicists, biomedical engineers and other engineers who are
interested in the science and technology aspects of Patient
Specific Modeling, as well as for radiologists and other medical
specialists who wish to be updated about the state of
implementation.
This book reviews the state-of-the-art in multiscale computer
modeling, in terms of both accomplishments and challenges. The
information in the book is particularly useful for biomedical
engineers, medical physicists and researchers in systems biology,
mathematical biology, micro-biomechanics and biomaterials who are
interested in how to bridge between traditional biomedical
engineering work at the organ and tissue scales, and the newer
arenas of cellular and molecular bioengineering.
This book describes these exciting new developments, and presents
experimental and computational findings that altogether describe
the frontier of knowledge in cellular and biomolecular mechanics,
and the biological implications, in health and disease. The book is
written for bioengineers with interest in cellular mechanics, for
biophysicists, biochemists, medical researchers and all other
professionals with interest in how cells produce and respond to
mechanical loads.
Pressure-related chronic wounds are an important health concern
that affects millions of patients and accumulates billions in
annual costs. These wounds may occur when soft tissues are
mechanically compressed between bony prominences and a supporting
surface. This book gives a complete and quantitative explanation of
the mechanobiology which causes chronic wounds. The reviews give an
overall picture on all length scales of the phenomenon, starting
from musculoskeletal biomechanics to the modeling of soft tissues
and their interaction with bones. At the microscopic levels, it
thoroughly reviews experiments and modeling of cellular forces and
molecular processes that occur during injury and healing, including
the integrity of living cells subjected to sustained mechanical
forces and deformations. The results allow a complete picture of
the tolerance of human tissues to sustained loads, and an
understanding of the risk for onset of chronic wounds. Hence, this
book is also valuable for all professionals involved in the
prevention and treatment of chronic wounds.
This book reviews the frontier of research and clinical
applications of Patient Specific Modeling, and provides a
state-of-the-art update as well as perspectives on future
directions in this exciting field. The book is useful for medical
physicists, biomedical engineers and other engineers who are
interested in the science and technology aspects of Patient
Specific Modeling, as well as for radiologists and other medical
specialists who wish to be updated about the state of
implementation.
This book describes these exciting new developments, and presents
experimental and computational findings that altogether describe
the frontier of knowledge in cellular and biomolecular mechanics,
and the biological implications, in health and disease. The book is
written for bioengineers with interest in cellular mechanics, for
biophysicists, biochemists, medical researchers and all other
professionals with interest in how cells produce and respond to
mechanical loads.
This volume describes the state-of-knowledge in the study of the
relationships between mechanical loading states in tissues and
common pathophysiologies related to increase in mass of adipose
tissues and/or hyperglycemia which eventually lead to obesity,
diabetes, insulin resistance, hyperlipidemia, metabolic
inflammations, certain types of cancer and other related diseases.
There appears to be an interaction between the loading states in
tissues and cells and these chronic conditions, as well as with
factors such as age, gender and genetics of the individual.
Bioengineering has made key contributions to this research field in
providing technologies for cell biomechanics experimentation,
microscopy and image processing, tissue engineering and
multi-scale, multi-physics computational modeling. Topics at the
frontier of this field of study include: the continuous monitoring
of cell growth, proliferation and differentiation in response to
mechanical factors such as stiffness of the extracellular matrix
(ECM) and mechanical loads transferred through the ECM;
mechanically-activated signaling pathways and molecular mechanisms;
effects of different loading regimes and mechanical environments on
differentiation fates of mesenchymal stem cells (MSCs) into
myogenic and osteogenic versus adipogenic lineages; the
interactions between nutrition and mechanotransduction; cell
morphology, focal adhesion patterns and cytoskeletal remodeling
changes in adipogenesis; activation of receptors related to
diabetes by mechanical forces; brown and white adipose plasticity
and its regulation by mechanical factors.
The Science, Etiology and Mechanobiology of Diabetes and Its
Complications presents the most comprehensive synthesis of
contemporary global research on diabetes, covering a novel and
unique mechanobiological perspective - addressing prevention,
management and treatment of tissue, organ and body system damage
associated with diabetes and its complications. The book provides a
unique approach to communicating diabetes-associated symptoms and
opens avenues for development of novel therapeutic and preventive
methods. It offers descriptive pathophysiology of diabetes and its
complications with great emphasis on mechanobiology. Content
coverage also includes management of tissue, organ and body system
damage caused by chronic hyperglycemia. Biologists, life
scientists, physicians, pharmacists, biomedical engineers, medical
physicists, biomathematicians and computer scientists who are
interested in the state-of-science and current challenges in the
mechanobiology of diabetes should find this book very useful.
Likewise, medical researchers in fields such as endocrinology,
cardiovascular medicine, oncology, obesity, the immune system,
inflammation and wound care and others who wish to be updated about
the latest achievements in this exciting arena of research will
find that information here.
Innovations and Emerging Technologies in Wound Care is a pivotal
book on the prevention and management of chronic and non-healing
wounds. The book clearly presents the research and evidence that
should be considered when planning care interventions to improve
health related outcomes for patients. New and emerging technologies
are discussed and identified, along with tactics on how they can be
integrated into clinical practice. This book offers readers a
bridge between biomedical engineering and medicine, with an
emphasis on technological innovations. It includes contributions
from engineers, scientists, clinicians and industry professionals.
Users will find this resource to be a complete picture of the
latest knowledge on the tolerance of human tissues to sustained
mechanical and thermal loads that also provides a deeper
understanding of the risk for onset and development of chronic
wounds.
Pressure-related chronic wounds are an important health concern
that affects millions of patients and accumulates billions in
annual costs. These wounds may occur when soft tissues are
mechanically compressed between bony prominences and a supporting
surface. This book gives a complete and quantitative explanation of
the mechanobiology which causes chronic wounds. The reviews give an
overall picture on all length scales of the phenomenon, starting
from musculoskeletal biomechanics to the modeling of soft tissues
and their interaction with bones. At the microscopic levels, it
thoroughly reviews experiments and modeling of cellular forces and
molecular processes that occur during injury and healing, including
the integrity of living cells subjected to sustained mechanical
forces and deformations. The results allow a complete picture of
the tolerance of human tissues to sustained loads, and an
understanding of the risk for onset of chronic wounds. Hence, this
book is also valuable for all professionals involved in the
prevention and treatment of chronic wounds.
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