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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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The Mechanobiology of Obesity and Related Diseases (Hardcover, 2015 ed.)
Loot Price: R1,449
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The Mechanobiology of Obesity and Related Diseases (Hardcover, 2015 ed.)
Series: Studies in Mechanobiology, Tissue Engineering and Biomaterials, 16
Expected to ship within 12 - 17 working days
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Total price: R1,469
Discovery Miles: 14 690
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This volume describes the state-of-knowledge in the study of the
relationships between mechanical loading states in tissues and
common pathophysiologies related to increase in mass of adipose
tissues and/or hyperglycemia which eventually lead to obesity,
diabetes, insulin resistance, hyperlipidemia, metabolic
inflammations, certain types of cancer and other related diseases.
There appears to be an interaction between the loading states in
tissues and cells and these chronic conditions, as well as with
factors such as age, gender and genetics of the individual.
Bioengineering has made key contributions to this research field in
providing technologies for cell biomechanics experimentation,
microscopy and image processing, tissue engineering and
multi-scale, multi-physics computational modeling. Topics at the
frontier of this field of study include: the continuous monitoring
of cell growth, proliferation and differentiation in response to
mechanical factors such as stiffness of the extracellular matrix
(ECM) and mechanical loads transferred through the ECM;
mechanically-activated signaling pathways and molecular mechanisms;
effects of different loading regimes and mechanical environments on
differentiation fates of mesenchymal stem cells (MSCs) into
myogenic and osteogenic versus adipogenic lineages; the
interactions between nutrition and mechanotransduction; cell
morphology, focal adhesion patterns and cytoskeletal remodeling
changes in adipogenesis; activation of receptors related to
diabetes by mechanical forces; brown and white adipose plasticity
and its regulation by mechanical factors.
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