Originating from the School on Birational Geometry of Hypersurfaces, this volume focuses on the notion of (stable) rationality of projective varieties and, more specifically, hypersurfaces in projective spaces, and provides a large number of open questions, techniques and spectacular results. The aim of the school was to shed light on this vast area of research by concentrating on two main aspects: (1) Approaches focusing on (stable) rationality using deformation theory and Chow-theoretic tools like decomposition of the diagonal; (2) The connection between K3 surfaces, hyperkahler geometry and cubic fourfolds, which has both a Hodge-theoretic and a homological side. Featuring the beautiful lectures given at the school by Jean-Louis Colliot-Thelene, Daniel Huybrechts, Emanuele Macri, and Claire Voisin, the volume also includes additional notes by Janos Kollar and an appendix by Andreas Hochenegger.