In this issue, guest editors bring their considerable expertise to this important topic. Contains 38 patient scenarios including a patient with a history of Down syndrome presenting for periodic examination and cleaning; a patient with dementia presenting from a nursing home with a history of decreased oral intake, malodor, and weight loss; a patient faints in the waiting area with a suspected hypoglycemic event; a patient with moderate to severe TMJ degenerative joint disease and unilateral joint pain presenting for oral medicine consult; a patient diagnosed with bulimia reports to the dental office seeking cosmetic dental work; and more.  Provides in-depth clinical reviews on clinical decisions in medically complex dental patients, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.