This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

This book focuses on the analysis of cancer dynamics and the mathematically based synthesis of anticancer therapy. It summarizes the current state-of-the-art in this field and clarifies common misconceptions about mathematical modeling in cancer. Additionally, it encourages closer cooperation between engineers, physicians and mathematicians by showing the clear benefits of this without stating unrealistic goals. Development of therapy protocols is realized from an engineering point of view, such as the search for a solution to a specific control-optimization problem. Since in the case of cancer patients, consecutive measurements providing information about the current state of the disease are not available, the control laws are derived for an open loop structure. Different forms of therapy are incorporated into the models, from chemotherapy and antiangiogenic therapy to immunotherapy and gene therapy, but the class of models introduced is broad enough to incorporate other forms of therapy as well. The book begins with an analysis of cell cycle control, moving on to control effects on cell population and structured models and finally the signaling pathways involved in carcinogenesis and their influence on therapy outcome. It also discusses the incorporation of intracellular processes using signaling pathway models, since the successful treatment of cancer based on analysis of intracellular processes, might soon be a reality. It brings together various aspects of modeling anticancer therapies, which until now have been distributed over a wide range of literature. Written for researchers and graduate students interested in the use of mathematical and engineering tools in biomedicine with special emphasis on applications in cancer diagnosis and treatment, this self-contained book can be easily understood with only a minimal basic knowledge of control and system engineering methods as well as the biology of cancer. Its interdisciplinary character and the authors' extensive experience in cooperating with clinicians and biologists make it interesting reading for researchers from control and system engineering looking for applications of their knowledge. Systems and molecular biologists as well as clinicians will also find new inspiration for their research.

One of the world's leading problems in the field of national security is protection of borders and borderlands. This book addresses multiple issues on advanced innovative methods of multi-level control of both ground (UGVs) and aerial drones (UAVs). Those objects combined with innovative algorithms become autonomous objects capable of patrolling chosen borderland areas by themselves and automatically inform the operator of the system about potential place of detection of a specific incident. This is achieved by using sophisticated methods of generation of non-collision trajectory for those types of objects and enabling automatic integration of both ground and aerial unmanned vehicles. The topics included in this book also cover presentation of complete information and communication technology (ICT) systems capable of control, observation and detection of various types of incidents and threats. This book is a valuable source of information for constructors and developers of such solutions for uniformed services. Scientists and researchers involved in computer vision, image processing, data fusion, control algorithms or IC can find many valuable suggestions and solutions. Multiple challenges for such systems are also presented.

One of the world s leading problems in the field of national security is protection of borders and borderlands. This book addresses multiple issues on advanced innovative methods of multi-level control of both ground (UGVs) and aerial drones (UAVs). Those objects combined with innovative algorithms become autonomous objects capable of patrolling chosen borderland areas by themselves and automatically inform the operator of the system about potential place of detection of a specific incident. This is achieved by using sophisticated

methods of generation of non-collision trajectory for those types of objects and enabling automatic integration of both ground and aerial unmanned vehicles.

The topics included in this book also cover presentation of complete information and communication technology (ICT) systems capable of control, observation and detection of various types of incidents and threats. This book is a valuable source of information for constructors and developers of such solutions for uniformed services. Scientists and researchers involved in computer vision, image processing, data fusion, control algorithms or IC can find many valuable suggestions and solutions. Multiple challenges for such systems are also presented. "