This book is concerned with data in which the observations are independent and in which the response is multivariate. Anthony Atkinson has been Professor of Statistics at the London School of Economics since 1989. Before that he was a Professor at Imperial College, London. He is the author of Plots, Transformations, and Regression, co-author of Optimum Experimental Designs, and joint editor of The Fascination of Statistics, a volume celebrating the centenary of the International Statistical Institute. Professor Atkinson has served as editor of The Journal of the Royal Statistical Society, Series B and as associate editor of Biometrika and Technometrics. He has published well over 100 articles in these and other journals including The Annals of Statistics, Biometrics, The Journal of the American Statistical Association, and Statistics and Computing. Marco Riani, after receiving his Ph.D. in Statistics in 1995 from the University of Florence, joined the Faculty of Economics at Parma University as postdoctoral fellow. In 1997 he won the prize for the best Italian Ph.D. thesis in Statistics. He is currently Associate Professor of Statistics in the University of Parma. He has published in Technometrics, The Journal of Computational and Graphical Statistics, The Journal of Business and Economic Statistics, The Journal of Forecasting, Environmetrics, Computational Statistics and Data Analysis, Metron, and other journals.

From the reviews:

"The book requires knowledge of multivariate statistical methods, because it provides only basic background information on the methods considered (although with excellent references for futher reading at the end of each chapter). Each chapter alsoincludes exercises with solutions...This book could serve as an excellent text for an advanced course on modern multivariate statistics, as it is intended." Technometrics, November 2004

"This book is full of interest for anyone undertaking multivariate analyses, clearly emphasizing that uncritical use of standard methods can be misleading." Short Book Reviews of the International Statistical Institute, December 2004

"This book is an interesting complement to various textbooks on multivariate statistics." Biometrics, December 2005

"This book discusses multivariate data from a different perspective. a ] it is an excellent book for researchers with interests in multivariate data and cluster analysis. It may also be a good reference for students of advanced statistics and practitioners working with large volumes of data a ] ." (Kassim S. Mwitondi, Journal of Applied Statistics, Vol. 32 (4), 2005)

"This is a companion to an earlier book a ] both of which feature many informative graphs. Here, the forward search has been applied in detail to classical multivariate approaches used with Gaussian data. a ] One valuable feature of the book is the way that the illustrations concentrate on a relatively small number a ] . This makes it easy to concentrate on the application a ] . The implications of this book also strengthen the importance of data visualization, as well as providing a valuable approach to visualization." (Paul Hewson, Journal of the Royal Statistical Society Series A, Vol. 168 (2), 2005)

"This book is a companion to Atkinson a ] . The objective is to identify outliers, appreciate their influence a ] which would result in an overall improvement. a ] Graphical tools arewidely used, resulting in three hundred and ninety figures. Each chapter is followed by extensive exercises and their solutions, and the book could be used as an advanced textbook for multivariate analysis courses. Web-sites provide the relevant software a ] . This book is full of interest for anyone undertaking multivariate analyses a ] ." (B.J.T. Morgan, Short Book Reviews International Statistical Institute, Vol. 24 (3), 2004)

"This book discusses forward search (FS), a method using graphs to explore and model continuous multivariate data a ] . Its viewpoint is toward applications, and it demonstrates the merits of FS using a variety of examples, with a thorough discussion of statistical issues and interpretation of results. a ] This book could serve as an excellent text for an advanced course on modern multivariate statistics, as it is intended." (Tena Ipsilantis Katsaounis, Technometrics, Vol. 46 (4), November, 2004)

"The theoretical exercises with detailed solutions at the end of each chapter are extremely useful. I would recommend this book to practitioners who analyze moderately sized multivariate data. Of course, anyone associated with the application of statistics should find the book interesting to read." (Tathgata Banerjee, Journal of the American Statistical Association, March 2006)

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training.

After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

Randomised Response-Adaptive Designs in Clinical Trials presents methods for the randomised allocation of treatments to patients in sequential clinical trials. Emphasizing the practical application of clinical trial designs, the book is designed for medical and applied statisticians, clinicians, and statisticians in training. After introducing clinical trials in drug development, the authors assess a simple adaptive design for binary responses without covariates. They discuss randomisation and covariate balance in normally distributed responses and cover many important response-adaptive designs for binary responses. The book then develops response-adaptive designs for continuous and longitudinal responses, optimum designs with covariates, and response-adaptive designs with covariates. It also covers response-adaptive designs that are derived by optimising an objective function subject to constraints on the variance of estimated parametric functions. The concluding chapter explores future directions in the development of adaptive designs.

This volume contains pioneering contributions to both the theory and practice of optimal experimental design. Topics include the optimality of designs in linear and nonlinear models, as well as designs for correlated observations and for sequential experimentation. There is an emphasis on applications to medicine, in particular, to the design of clinical trials. Scientists from Europe, the US, Asia, Australia and Africa contributed to this volume of papers from the 11th Workshop on Model Oriented Design and Analysis.

This book collects the proceedings of the 10th Workshop on Model-Oriented Design and Analysis (mODa). A model-oriented view on the design of experiments, which is the unifying theme of all mODa meetings, assumes some knowledge of the form of the data-generating process and naturally leads to the so-called optimum experimental design. Its theory and practice have since become important in many scientific and technological fields, ranging from optimal designs for dynamic models in pharmacological research, to designs for industrial experimentation, to designs for simulation experiments in environmental risk management, to name but a few. The methodology has become even more important in recent years because of the increased speed of scientific developments, the complexity of the systems currently under investigation and the mounting pressure on businesses, industries and scientific researchers to reduce product and process development times. This increased competition requires ever increasing efficiency in experimentation, thus necessitating new statistical designs. This book presents a rich collection of carefully selected contributions ranging from statistical methodology to emerging applications. It primarily aims to provide an overview of recent advances and challenges in the field, especially in the context of new formulations, methods and state-of-the-art algorithms. The topics included in this volume will be of interest to all scientists and engineers and statisticians who conduct experiments.

The International Statistical Institute was founded in 1885 and is therefore one of the world's oldest international scientific societies. The field of statistics is still expanding rapidly and possesses a rich variety of applications in many areas of human activity such as science, government, business, industry, and everyday affairs. In consequence, the celebration of the Institute's centenary in 1985 is of considerable interest not only to statisticians but also more widely to the international scientific community. As part of its centennial celebration planning the Institute decided to publish a volume of papers representing the immensely wide range of interests encompassed by statistics in its international context, viewed both from a historical and from a contemporary standpoint. We were fortunate in securing the services of Anthony Atkinson and Stephen Fienberg as Editors of this volume: they have worked hard over a period of several years to put together a most fascinating collection of papers. On behalf of the Institute it is my pleasant duty to thank them and the authors for their contributions. J. DURBIN, President International Statistical Institute Preface The papers in this volume were prepared to help celebrate the centenary of the International Statistical Institute. During the lSI's first 100 years statistics has matured, both as a scientific discipline and as a profession, in ways that the lSI's founders could not possibly have imagined.

This book is concerned with data in which the observations are independent and in which the response is multivariate.

Companion book to Robust Diagnostic Regression Analysis (ISBN 0-387-95017) published by Springer in 2000.

This book includes many of the papers presented at the 6th International workshop on Model Oriented Data Analysis held in June 2001. This series began in March 1987 with a meeting on the Wartburg near Eisenach (at that time in the GDR). The next four meetings were in 1990 (St Kyrik monastery, Bulgaria), 1992 (Petrodvorets, St Petersburg, Russia), 1995 (Spetses, Greece) and 1998 (Marseilles, France). Initially the main purpose of these workshops was to bring together leading scientists from 'Eastern' and 'Western' Europe for the exchange of ideas in theoretical and applied statistics, with special emphasis on experimental design. Now that the sep aration between East and West is much less rigid, this exchange has, in principle, become much easier. However, it is still important to provide opportunities for this interaction. MODA meetings are celebrated for their friendly atmosphere. Indeed, dis cussions between young and senior scientists at these meetings have resulted in several fruitful long-term collaborations. This intellectually stimulating atmosphere is achieved by limiting the number of participants to around eighty, by the choice of a location in which communal living is encour aged and, of course, through the careful scientific direction provided by the Programme Committee. It is a tradition of these meetings to provide low cost accommodation, low fees and financial support for the travel of young and Eastern participants. This is only possible through the help of sponsors and outside financial support was again important for the success of the meeting."

This volume contains the majority of the papers presented at the 5th Inter national Workshop on Model-Oriented Data Analysis held in June 1998. This series started in March 1987 with a meeting on the Wartburg, Eisenach (Germany). The next three meetings were in 1990 (St Kyrik monastery, Bulgaria), 1992 (Petrodvorets, StPetersburg, Russia) and 1995 (Spetses, Greece). The main purpose of these workshops was to bring together lead ing scientists from 'Eastern' and 'Western' Europe for the exchange of ideas in theoretical and applied statistics, with special emphasis on experimen tal design. Now that the separation between East and West has become less rigid, this dialogue has, in principle, become much easier. However, providing opportunities for this dialogue is as vital as ever. MODA meetings are known for their friendly atmosphere, leading to fruitful discussions and collaboration, especially between young and senior scien tists. Indeed, many long term collaborations were initiated during these events. This intellectually stimulating atmosphere is achieved by limiting the number of participants to around eighty, by the choice of location so that participants can live as a community, and, of course, through the care ful selection of scientific direction made by the Programme Committee."

Drawn from the proceedings of the 9th Workshop on Model-Oriented Design and Analysis, this text covers the latest theory and applications on optimal experimental designs. Topics include designs for nonlinear models, multivariate data and medical applications.