Randomised Response-Adaptive Designs in Clinical Trials presents
methods for the randomised allocation of treatments to patients in
sequential clinical trials. Emphasizing the practical application
of clinical trial designs, the book is designed for medical and
applied statisticians, clinicians, and statisticians in training.
After introducing clinical trials in drug development, the authors
assess a simple adaptive design for binary responses without
covariates. They discuss randomisation and covariate balance in
normally distributed responses and cover many important
response-adaptive designs for binary responses. The book then
develops response-adaptive designs for continuous and longitudinal
responses, optimum designs with covariates, and response-adaptive
designs with covariates. It also covers response-adaptive designs
that are derived by optimising an objective function subject to
constraints on the variance of estimated parametric functions. The
concluding chapter explores future directions in the development of
adaptive designs.
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