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Given the latest advances in cancer research, which includes basic
research and its derived diagnostic, clinical, and therapeutic
applications, the book New Trends in Cancer for the 21st Century is
written by individuals such as molecular biologists, whose tasks
are to decipher, after sequencing the human genome, those new genes
and pathways involved in the carcinogenesis process; clinical and
molecular pathologists, who apply these discoveries for the
molecular diagnosis and characterization of the tumor; and clinical
oncologists, who treat patients. Pharmacogenetics introduces new
perspectives in the translational fields with the design of drugs
against specific targets, which at this moment are in clinical
trials phases. This book achieves a state of the art in every field
of cancer research and discusses the new perspectives that will
open the future for cancer treatment (basic research, new
technologies, new drugs, therapies...). For this reason, the book
is intended for pathologists, clinicians, and biologists, as well
as fellows and students of physiology and medicine.
It is difficult to imagine anyone who has not heard of cancer.
This disease can affect families, friends or any one of us at any
time in our lives. Every year nearly 3 million Europeans are
diagnosed with cancer, leading to around 800,000 deaths per year.
These deaths occur not only in aging populations, but also in
children and adults who are in the most active period of their
lives. This represents a tremendous problem that cannot be ignored
by politicians or citizens. Fortunately, there is a constantly
growing awareness that although cancer is a problem to be dealt
with by clinicians, it should also be the concern of everyone. This
volume contains the lectures held at the International Symposium on
Cancer "New Trends in Cancer for the 21st Century." Fundamental
researchers, politicians and representatives from patient
coalitions share here their knowledge and interests as well as
their concerns and experiences. Not only do these papers provide
state-of-the-art information on cancer, they are also an
opportunity to look at the problem from different points of view.
It can be encouraging to realise that we are not alone in this
fight.
It has been over a decade since the First International Symposium
on Hormonal Carcinogenesis convened in 199 1. Since then, the field
has rapidly expanded with considerable progress in both breast and
prostate cancers; while ovarian and endometrial cancer have been
hampered, in part, due to the absence of suitable hormone-mediated
animal models. While knock-out, transgenic, and cell-culture
systems have been extremely useful in identifying specific
genelprotein alterations and the ensuing pathways affected, the
precise molecular mechanisms whereby sex hormones elicit their
oncogenic effects still remain elusive. Moreover, despite the
considerable progress made in breast cancer research, the exact
role of progestins in the presence or absence of estrogen in breast
growth, differentiation, and malignant transformation is lacking.
Elucidating the incipient molecular alterations in
earlylpre-invasive lesions elicited by these hormones is a growing
important focus of this field. The main purpose of these Symposia
has been to address vital questions that impact our understanding
of the causation, dependency, progression, resistance, and
prevention of hormonally-associated cancers. We are indebted to the
Scientific Advisory Board members who worked with us reviewing and
offering suggestions to finalize the scientific program. We offer
special thanks for the guidance and support of Dr. Gerald Mueller.
His wisdom played an indispensable role in maintaining the
excellence of these Symposia. We also acknowledge the numerous
external reviewers that worked diligently to revise and improve the
quality of the manuscripts. We are very grateful to Ms. Tandria
Price.
It is difficult to imagine anyone who has not heard of cancer. This
disease can affect families, friends or any one of us at any time
in our lives. Every year, nearly 3 million Europeans are diagnosed
with cancer, leading to around 800,000 deaths per year. These
deaths occur not only in aging populations, but also in children
and adults who are in the most active period of their lives. This
represents a tremendous problem that cannot be ignored by
politicians or citizens. Fortunately, there is a constantly growing
awareness that although cancer is a problem to be dealt with by
clinicians, it should also be the concern of everyone. This volume
contains the lectures held at the International Symposium on Cancer
New Trends in Cancer for the 21st Century. Fundamental researchers,
politicians and representatives from patient coalitions share here
their knowledge and interests as well as their concerns and
experiences.
Given the latest advances in cancer research, which includes basic
research and its derived diagnostic, clinical, and therapeutic
applications, the book New Trends in Cancer for the 21st Century is
written by individuals such as molecular biologists, whose tasks
are to decipher, after sequencing the human genome, those new genes
and pathways involved in the carcinogenesis process; clinical and
molecular pathologists, who apply these discoveries for the
molecular diagnosis and characterization of the tumor; and clinical
oncologists, who treat patients. Pharmacogenetics introduces new
perspectives in the translational fields with the design of drugs
against specific targets, which at this moment are in clinical
trials phases. Several organizations such as the EORTC (European
Organization for Research and Treatment of Cancer) and the OECI
(Organization of European Cancer Institutes) and comprehensive
cancer centers play a crucial role in focusing cancer research on
all these areas.
This book achieves a state of the art in every field of cancer
research and discusses the new perspectives that will open the
future for cancer treatment (basic research, new technologies, new
drugs, therapies...). For this reason, the book is intended for
pathologists, clinicians, and biologists, as well as fellows and
students of physiology and medicine.
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