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Hormonal Carcinogenesis IV (Hardcover, 4th Revised edition)
Loot Price: R4,442
Discovery Miles 44 420
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Hormonal Carcinogenesis IV (Hardcover, 4th Revised edition)
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It has been over a decade since the First International Symposium
on Hormonal Carcinogenesis convened in 199 1. Since then, the field
has rapidly expanded with considerable progress in both breast and
prostate cancers; while ovarian and endometrial cancer have been
hampered, in part, due to the absence of suitable hormone-mediated
animal models. While knock-out, transgenic, and cell-culture
systems have been extremely useful in identifying specific
genelprotein alterations and the ensuing pathways affected, the
precise molecular mechanisms whereby sex hormones elicit their
oncogenic effects still remain elusive. Moreover, despite the
considerable progress made in breast cancer research, the exact
role of progestins in the presence or absence of estrogen in breast
growth, differentiation, and malignant transformation is lacking.
Elucidating the incipient molecular alterations in
earlylpre-invasive lesions elicited by these hormones is a growing
important focus of this field. The main purpose of these Symposia
has been to address vital questions that impact our understanding
of the causation, dependency, progression, resistance, and
prevention of hormonally-associated cancers. We are indebted to the
Scientific Advisory Board members who worked with us reviewing and
offering suggestions to finalize the scientific program. We offer
special thanks for the guidance and support of Dr. Gerald Mueller.
His wisdom played an indispensable role in maintaining the
excellence of these Symposia. We also acknowledge the numerous
external reviewers that worked diligently to revise and improve the
quality of the manuscripts. We are very grateful to Ms. Tandria
Price.
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