The book is a practical guide for neurosurgeons and radiation oncologists willing to better understand the contemporary multimodal management of neurosurgical diseases including, but not limited to, stereotactic radiosurgery (SRS). Since its invention 1950s, SRS has dramatically impacted the treatment and prognosis of several neurosurgical diseases such as brain and spine metastases, intracranial and spinal arteriovenous malformations, benign head and spine tumors, functional neurological diseases, etc. The book is formed by 35 chapters encompassing all aspects of SRS, from basic principles to the traditional and novel clinical applications. Each chapter points out the current evidence-based indications, contraindications, and adverse effects of SRS and other techniques that should be considered as an alternative or as a complement to SRS.