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Diverse specialised neuroglial cells guarantee the development,
preservation, and health of the central nervous system, the
peripheral nervous system, the enteric nervous system, and the
special senses. In the central nervous system, it is the
astrocytes, oligodendrocytes, and microglia that safeguard nerve
cell function and integrity that controls all behaviours and
encompasses the cerebral cortex of the brain which is the root of
humanity. In the peripheral nervous system, Schwann cells play the
leading role, together with satellite glial cells of the sensory
and autonomic ganglia, ensuring correct communication between the
organs and tissues with the brain and the spinal cord. In the
enteric nervous system, specialised enteric glial cells maintain
all aspects of gastrointestinal function. Then there are
distinctive glial cells of the special senses that ensure how the
body perceives and reacts to its environment. In pathology,
neuroglia strive to protect the diverse cellular components of the
nervous system and are responsible for a proactive programme of
posttraumatic restructuring that is aimed at recovery of
life-sustaining function. Neuroglia: Function and Pathology
provides a highly original and comprehensive account of the
physiology and pathophysiology of glial cells in the central and
peripheral nervous systems. The first part of the book provides a
far-reaching description of glial cell form and function, from
their evolution in invertebrates to their complexity in humans,
encompassing the developmental origin of the varied glial cell
types and their diversity of morphology, molecular biology and
cellular physiology. The second part of the book is devoted to an
all-embracing evaluation of glial cell pathophysiology, commencing
with definitive explanations of the fundamental pathologies of the
main glial cell types, and ending in a systematic examination of
glial contributions to specific neurological diseases. This book
emphasises the central roles played by the different classes of
neuroglial cells in the progression and outcome of neurological
disorders of the central and peripheral nervous systems and
highlights potential of glial cells as therapeutic targets. The
book contains more than 2500 key references from over 150 years of
glial research and is superbly illustrated with over 350 original
and explanatory full colour figures that describe the diverse
characteristics and properties of glial cells in health and
disease. Under the same cover, this book combines an authoritative
reference book for research and clinical neuroscientists and at the
same time serves as an instructive textbook for students of
neuroscience, from undergraduates to postgraduates.
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