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The field of steroid hormone action has continued to expand into
the realm of molecular biology at a pace even faster than most of
us ever imagined. techniques of molecular biology have made it
possible to clone The hormone-regulated genes and to examine
steroid-receptor interactions with these genes. Nucleotide
sequences of these genes, which show preferential binding of
steroid receptors, have been identified. These results are
complemented by the identification of chromatin acceptor proteins,
which also show preferential binding for steroid-receptor
complexes. Thus, one can envision the day when cloned genes,
purified acceptor proteins, and receptor-steroid complexes will be
recombined in vitro to form a functional unit. Cellular
localization of steroid receptors has undergone recent revision,
and it now appears that receptors are localized primarily in the
nuclear compartment. These findings, although controversial, will
lead to a reassessment of many of the previous concepts of
steroid-receptor interactions and regulation. The way in which
these observations at the of physiology, molecular and cellular
levels fit into the overall scheme development, and evolution are
continuing to progress, and the future promises some very exciting
syntheses of understanding at all levels of biological
organization. The third Meadow Brook Conference on hormones was
held in order to bring together investigators who will undoubtedly
contribute heavily to this future synthesis and to permit a free
exchange of ideas and concepts as they relate to the current
state-of-the-art in molecular endocrinology. Spring 1986 ARUN K.
Roy JAMES H. CLARK Contents Preface. . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . v Contributors . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . .
The first Meadowbrook Symposium was held in 1978 and during the
intervening ten years our knowledge concerning how steroid hormones
function at the level of gene expression has advanced by leaps and
bounds. In this volume, which sum marizes our fourth meeting, these
advances are very evident. What seemed like science fiction ten
years ago has become commonplace science. Who would have imagined
that we could synthesize a nucleotide sequence that binds a
specific steroid receptor and acts as a controlling element for
gene expression? No one; but as is evident from the results
reported in several chapters, this technique is yielding a wealth
of information. Using these and other techniques it has become
apparent that gene transcription is controlled by interactions
between transacting factors and DNA recognition sequences (response
elements). These transacting factors appear to be members of a
large gene family that includes steroid hormone receptors,
transcription factors, protooncogenes and homeobox proteins. Thus a
great deal has been learned, but as usual, questions remain. Many
of these questions are posed by the findings and observations found
in several chapters in this volume. Non hormone binding forms of
steroid receptors and their relevance to receptor down regulation,
recycling and biological response remain a mystery. The
quantitative relationship between receptor binding and biological
response still presents agonizing problems. These and many other
intriguing questions are discussed in this volume and set the stage
for what should be a most rewarding time in endocrinology. Winter
1989 ARUN K."
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