Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers. Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.

Intended for practising rheumatologists, this book will also be useful for postgraduate students and internists with an interest in rheumatology. It familiarises clinicians involved in the care of patients with spondyloarthritis (SpA) with various common and uncommon imaging features of these disorders. In addition, it will serve as a reference for comparison of imaging features observed by clinicians in their day-to-day practice. The purpose is to make it easier for a rheumatologist to understand the report given by a radiologist in this context and to participate with a basic understanding during multidisciplinary meetings involving radiology colleagues. The aim is to ensure better patient care through shared understanding of imaging findings. Detailed illustrations and explanation of various imaging findings in patients with spondyloarthritis. Basic science of MRI and its sequences have been explained in a simple language which rheumatologists and internists can understand. Various uncommon imaging features like entheseal inflammation and ligamentous ossification have been nicely illustrated. Provides a vivid collection of plain radiographs, MRIs and CT scans obtained during care of patients with spondyloarthritis. Both the axial and peripheral joints have been included.

EVOLVING NETWORKING TECHNOLOGIES This book discusses in a practical manner some of the critical security challenges facing the ever-evolving networking technologies of today. In an age of explosive worldwide growth of electronic data storage and communications, effective protection of information has become a critical requirement, especially when used in coordination with other tools for information security and cryptography in all of its applications, including data confidentiality, data integrity, and user authentication. While the importance of cryptographic technique, i.e., encryption, in protecting sensitive and critical information and resources cannot be overemphasized, an examination of the technical evolution within several industries reveals an approaching precipice of scientific change. The glacially paced but inevitable convergence of quantum mechanics, nanotechnology, computer science, and applied mathematics will revolutionize modern technology. The implications of such changes will be far-reaching, with one of its greatest impacts affecting information security and, more specifically, modern cryptography. The book takes the reader through these issues. As the security systems design becomes more and more complex to meet these challenges, a mistake that is committed most often by security specialists is not making a comprehensive analysis of the system to be secured before choosing which security mechanism to deploy. Often, the security mechanism chosen turns out to be either incompatible with, or inadequate for, handling the complexities of the system. In addition, the book also discusses three main points: Configuration management is a critical issue, and as networks are increasing in size, their configuration needs to be managed. Devices may conflict with each other in terms of configuration. Therefore, it becomes challenging for firewalls to be up-to-date according to network policies. Scalability of the network is another big challenge, it would be easier to address if the network stays the same, but the network is ever expanding with a constant increase in the number of devices devoted to the network. Vendor lock-in: Business decisions that are taken today are revolving around the assumptions and capabilities of the current vendor and environment scenario. Buying the best solutions from today’s vendors involves how to interoperate, integrate, and support multiple solutions. It may involve tearing out all of the longstanding kits without tearing down the entire network at the same time. Audience This book specifically appeals to industry practitioners, IT researchers, and students regarding network technological management.