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Major and exciting advances in psychiatric genetics were discussed
at a 3-day international workshop. The internationally renowned
editors assembledan impressive list of specialists, all of whom are
leading in their subject. Reviews and short articles which stress
special problems or new research results have been brought together
in this book, also including intensive discussions of the different
topics. Much of the material covers the application of molecular
genetics in major psychoses, Alzheimer's dementia or preclinical
research. However, the problems of diagnostic features or
phenotypical characterization broaden further the content of this
volume, making it truly a collection of the art information.
The discovery of chlorpromazine for the specific treatment of
schizophrenic symp toms and, later on, of imipramine for the
specific treatment of depressive symptoms marked a new milestone in
clinical psychiatry and basic neuroscience 40 years ago. The
exploration of biochemical mechanisms of action of these
psychotropic drugs created new theories on the pathophysiology of
psychiatric disorders, such as the dopamine hypothesis of
schizophrenia and the catecholamine and serotonin hypotheses of
depression. Thus the discovery of these biological treatments had a
major impact on natural science-oriented research. Biological
psychiatry as we know it today has its origin in these
psychopharmacological drugs and influences many disciplines in
psychiatry. It was a fortunate coincidence that Hans Hippius, whose
70th birthday we celebrated this year with an international
symposium, started his professional career during this time in the
1950S. He was one of the early pioneers in clinical psycho
pharmacological research and enthusiastic about both the scientific
and the thera peutic prospects of the new psychotropic drugs. He
has worked in this field for more than three decades and has made
many lasting contributions to biological psychiatry. Among the many
activities, his contributions in the development of the new
atypical antipsychotic drug clozapine should be mentioned."
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