Contents. List of Contributors. Brian Henderson and Gerry Higgs: Targets for modulating cytokine responses in inflammatory and infectious diseases. Mary Lee MacKichan and Anthony L. DeFranco: Cell signalling and cytokine induction by lipopolysaccharide. Rodger A. Allen and Stephen E. Rapecki: Regulation of cytokine production by inhibitors of cell signalling. Stanley T. Crooke: Oligonucleotide-based drugs in the control of cytokine synthesis. Peter I. Croucher, Ingunn Holen and Philip G. Hargreaves: Inhibiting cytokine-processing enzymes. Amanda Suitters and Roly Foulkes: Cytokine-neutralizing therapeutic antibodies. Ravinder N. Maini: The debut of anti-TNF therapy of rheumatoid arthritis in the clinic. Anthony Meager: Blockade of cytokine activity by soluble cytokine receptors. Michael F. Smith Jr.: Interleukin-1 receptor antagonist. Raymond J. Owens and Simon Lumb: Therapeutic regulation of cytokine signalling by inhibitors of p38 mitogen-activated protein kinase. Christian Bogdan, Yoram Vodovotz and John Letterio: TGF-ss and IL-10: inhibitory cytokines regulating immunity and the response to infection. Brian Henderson: Therapeutic control of cytokines: lessons from microorganisms. Index

Is residential care 'inherently harmful'? This book argues that this conventional wisdom is wrong and is, itself, harmful to a significant number of children and youth. The presumptive view is based largely on overgeneralizations from research with infants and very young children raised in extremely deprived environments. A careful analysis of the available research supports the use of high-quality residential care as a treatment of choice with certain groups of needy children and youth, not a last resort intervention. The nature of high-quality care is explored through child development theory and research and two empirically supported models of care are described in detail. It will be of interest to all scholars and students of child development, child welfare, youth work, social work and education as well as professionals working within these fields.

In part the book creates and motivates the notion of metamodelling and how it can be used to standardise the creation of industry-strength design. At its heart, the book presents an analysis of the main object-oriented design methodologies, including: Booch, OMT, Coad, and Martin/Odell. Based on these descriptions, a proposal is made for a core metamodel framework into which the leading methodologies may be fitted. As a result, software engineers and software managers will find this a valuable "road map" in the future development of software standards.

"Epiphanics" (ep a fan' iks) are small epiphanies from simple experiences or commonplace occurrences. The intuitive perceptions can be light, medium, or dark.

These are the rules for my one-breath poetry: use only one sentence, ten or more lines, a strict rhyme scheme; and be able to read the poem in one breath.

Free

You can live
without regard
to the length
or shortness
of the day
and be free
from swift
or sluggish time
if you keep
your heart
unmoved
by sadness,
untouched
by joy.

Take the intimidation out of medical terminology Every job in the medical field needs some background in medical terminology. From the check-in desk to the doctor to the pharmaceutical sales rep, and everyone around and in between, healthcare professionals and those in adjacent fields use a common and consistent vocabulary to improve quality, safety, and efficiency. Medical Terminology For Dummies is a powerful resource for current and prospective healthcare professionals. It provides different ways to memorize the words and their meanings, including ideas for study materials, flash cards, quizzes, mind maps, and games. Plus, you'll discover how to identify, pronounce, define, and apply words in proper context. Grasp the standardized language of medicine Find the easiest way to remember tongue-twisting terms Benefit from lots of definitions and examples Understand, retain, and put this knowledge to use If you're one of the millions of professionals hoping to succeed in this booming field, this book gets you talking the talk so you can walk the walk!

This book focuses on metamodelling as a discipline, exploring its foundations, techniques and results. It presents a comprehensive metamodel that covers process, product and quality issues under a common framework.

Issues covered include: An explanation of what metamodelling is and why it is necessary in the context of software engineering. Basic concepts and principles of traditional metamodelling, and some existing results of this approach. Problems associated with traditional approaches to Metamodelling are discussed, alongside an exploration of possible solutions and alternative approaches. Advanced topics such as the extension of the object-oriented paradigm for metamodelling purposes or the foundations of powertype-based tool development will be studied. Finally, a comprehensive case study is introduced and developed, showing how to use many of the concepts explained in the previous chapters.

This book provides a comprehensive conceptual framework for metamodelling and includes case studies and exercises which will demonstrate practical uses of metamodelling. For lecturers and educators, the book provides a layered repository of contents, starting from the basics of metamodelling in the first chapters, through specific issues such as trans-layer control or non-strict approaches, up to advanced topics such as universal powertyping or extensions to the object-oriented paradigm. The book also serves as an in-depth reference guide to features and technologies to consider when developing in-house software development methods or customising and adopting off-the-shelf ones. Software tool developers and vendors can benefit from the book by finding in it a comprehensive guide tothe implementation of frameworks and toolsets for computer-aided software modelling and development.

The past 25 years has seen the emergence of a wealth of data suggesting that novel biological functions of known proteins play important roles in biology and medicine. This ability of proteins to exhibit more than one unique biological activity is known as protein moonlighting. Moonlighting proteins can exhibit novel biological functions, thus extending the function of the proteome, and are also implicated in the pathology of a growing number of idiopathic and infectious diseases. This book, written by a cell biologist, protein evolutionary biologist and protein bioinformatician, brings together the latest information on the structure, evolution and biological function of the growing numbers of moonlighting proteins that have been identified, and their roles in human health and disease. This information is revealing the enormous importance protein moonlighting plays in the maintenance of human health and in the induction of disease pathology. Protein Moonlighting in Biology and Medicine will be of interest to a general readership in the biological and biomedical research community.

After the events in Wounded Sky, Cole and Eva arrive in Winnipeg, the headquarters of Mihko Laboratories. They are intent on destroying the company once and for all, but their plans are thwarted when a new threat surfaces. When Cole becomes mired in terrifying visions, Eva must harness her newly discovered powers to investigate Mihko without him. Are Cole's visions just troubled dreams, or are they leading him to a horrible truth? Perfect for fans of superheroes, The Bloodhound Gang returns in this all-new graphic novel series, The Reckoner Rises.

Inspired by true events, this story of strength, family, and culture shares the awe-inspiring resilience of Elder Betty Ross. Abandoned as a young child, Betsy is adopted into a loving family. A few short years later, at the age of 8, everything changes. Betsy is taken away to a residential school. There she is forced to endure abuse and indignity, but Betsy recalls the words her father spoke to her at Sugar Falls--words that give her the resilience, strength, and determination to survive. Sugar Falls is based on the true story of Betty Ross, Elder from Cross Lake First Nation. We wish to acknowledge, with the utmost gratitude, Betty's generosity in sharing her story. A portion of the proceeds from the sale of Sugar Falls goes to support the bursary program for The Helen Betty Osborne Memorial Foundation. This 10th-anniversary edition brings David A. Robertson's national bestseller to life in full colour, with a foreword by The Hon. Murray Sinclair, Chair of the Truth and Reconciliation Commission of Canada, and a touching afterword from Elder Betty Ross herself.

Laser-based optical spectroscopies are powerful and versatile techniques that are continuing to evolve and find new applications. This book presents reviews of recent progress in our understanding of the spectra and dynamical processes of optically excited states of condensed matter, focusing on the advances made possible by the application of laser-based optical spectroscopies. Reviews are given of the optical properties of crystalline and amorphous semiconducting materials and structures, the properties of defect centers in insulators, two-photon nonlinear processes in insulators, optical energy diffusion in inorganic materials, and relaxation in organic materials. The individual chapters emphasize the methodology common to the various investigations. The volume is designed to be suitable as an introduction to applied laser spectroscopy of solids, as well as providing an update on the status of the field.

The Advanced Study Institute of which this volume is the proceedings was held at the University of Exeter during 24 August to 6 September 1975. There were seventy participants of whom eighteen were lecturers and members of the advisory committee. All NATO countries except Holland, Iceland and Portugal were re presented. In addition a small number of participants came from non-NATO countries Japan, Ireland and Switzerland. An aim of the organising committee was to bring together scientists of wide interests and expertise in the defect structure of insulators and semiconductors. Thus major emphases in the pro gramme concerned the use of spectroscopy and microscopy in revealing the structure of point defects and their aggregates, line defects as well as planar and volume defects. The lectures revealed that in general little is known of the fate of the interstitial in most irradiated solids. Nor are the dynamic properties of defects under stood in sufficient detail that one can state how point defects cluster and eventually become macroscopic defects. Although this book faithfully reproduces the material covered by the invited speakers, it does not really follow the flow of the lectures. This is because it seemed advisable for each lecturer to provide a single self-contained and authoritative manuscript, rather than a series of short articles corresponding to the lectures."

In part the book creates and motivates the notion of metamodelling and how it can be used to standardise the creation of industry-strength design. At its heart, the book presents an analysis of the main object-oriented design methodologies, including: Booch, OMT, Coad, and Martin/Odell. Based on these descriptions, a proposal is made for a core metamodel framework into which the leading methodologies may be fitted. As a result, software engineers and software managers will find this a valuable "road map" in the future development of software standards.

In Road Allowance Era, Echo's story picks up again when she travels back in time to 1885. The government has not fulfilled its promise of land for the Metis, and many flee to the Northwest. As part of the fallout from the Northwest Resistance, their advocate and champion Louis Riel is executed. As new legislation corrodes Metis land rights, and unscrupulous land speculators and swindlers take advantage, many Metis settle on road allowances and railway land, often on the fringes of urban centres. For Echo, the plight of her family is apparent. Burnt out of their home in Ste. Madeleine, they make their way to Rooster Town, a shanty community on the southwest edges of Winnipeg. In this final instalment of her story, Echo is reminded of the strength and resilience of her people, forged through the loss and pain of the past, as she faces a triumphant future.

After finding out Mihko reinstated the Reckoner Initiative in Breakdown, Cole and Eva confronted Mihko head-on. But when Eva stumbles across a secret laboratory, she finds her worst nightmares come to life. After a vicious battle with Mihko's newest test subject leaves Cole close to death, Eva is forced to continue their investigation without him. With Brady missing and Cole in recovery, Eva is on her own. What new terrors has Mihko created? Can they be stopped? And can Eva find Brady before it's too late?

Métis teenager Echo Desjardins is struggling to adjust to a new school and a new home. When an ordinary history class turns extraordinary, Echo is pulled into a time-travelling adventure. Follow Echo as she experiences pivotal events from Métis history and imagines what the future might hold. This omnibus edition includes all four volumes in the A Girl Called Echo series: In Pemmican Wars, Echo finds herself transported to the prairies of 1814. She witnesses a bison hunt, visits a Métis camp, and travels the fur-trade routes. Experience the perilous era of the Pemmican Wars and the events that lead to the Battle of Seven Oaks. In Red River Resistance, we join Echo on the banks of the Red River in the summer of 1869. Canadian surveyors have arrived and Métis families, who have lived there for generations, are losing their land. As the Resistance takes hold, Echo fears for the future of her people in Red River. In Northwest Resistance, Echo travels to 1885. The bison are gone and settlers from the East are arriving in droves. The Métis face starvation and uncertainty as both their survival and traditional way of life are threatened. The Canadian government has ignored their petitions, but hope rises with the return of Louis Riel. In Road Allowance Era, Echo returns to 1885. Louis Riel is standing trial, and the government has not fulfilled its promise of land for the Métis. Burnt out of their home in Ste. Madeleine, Echo's people make their way to Rooster Town, a shanty community on the southwest edges of Winnipeg. In this final instalment, Echo is reminded of the strength and perseverance of the Métis. This special omnibus edition of Katherena Vermette's best-selling series features an all-new foreword by Chantal Fiola (Returning to Ceremony: Spirituality in Manitoba Métis Communities), a historical timeline, and an essay about Métis being and belonging by Brenda Macdougall (Contours of a People: Métis Family, Mobility, and History).

Cellular microbiology is an exciting new area of microbiology research which bridges the gap between microbiology and cell biology. Drawing on their own teaching and research experience, the authors have provided a timely and comprehensive introduction to the molecular and cellular biology of bacterial interactions with host cells, and their relevance to human diseases. Cellular Microbiology introduces the key concepts of prokaryotic and eukaryotic cell biology, cell signalling mechanisms and current molecular biological techniques used in cellular microbiology before describing how bacteria interact with host eukaryotic cells during infections and health, and explaining the interactions with the immune system which enable an individual to recover from infections. This book will be invaluable to advanced undergraduate and postgraduate students studying microbiology, virology, pathology, pharmacology and cell biology. It will also be useful for those researchers interested in bacterial infection.

Echo Desjardins is adjusting to her new home, finding friends, and learning about Metis history. She just can't stop slipping back and forth in time. One ordinary afternoon in class, Echo finds herself transported to the banks of the Red River in the summer of 1869. All is not well in the territory as Canadian surveyors have arrived to change the face of territory, and Metis families, who have lived there for generations, are losing access to their land. As the Resistance takes hold, Echo fears for her friends and the future of her people in the Red River Valley.

Echo Desjardins just can't stop slipping back and forth in time. In Northwest Resistance, Echo travels to 1885, a period of turmoil. The bison are gone, settlers from the East are arriving daily, and the Metis and First Nations of the Northwest face hunger and uncertainty as their traditional way of life is threatened. The Canadian government has ignored their petitions, but hope rises when Louis Riel returns to help. However, battles between Canadian forces and the Metis and their allies lead to defeat at Batoche. Through it all, Echo gains new perspectives about where she came from and what the future may hold.

Echo Desjardins, a 13-year-old Metis girl adjusting to a new home and school, is struggling with loneliness while separated from her mother. Then an ordinary day in Mr. Bee's history class turns extraordinary, and Echo's life will never be the same. During Mr. Bee's lecture, Echo finds herself transported to another time and place--a bison hunt on the Saskatchewan prairie--and back again to the present. In the following weeks, Echo slips back and forth in time. She visits a Metis camp, travels the old fur-trade routes, and experiences the perilous and bygone era of the Pemmican Wars. Pemmican Wars is the first graphic novel in a new series, A Girl Called Echo, by Governor General Award-winning writer, and author of Highwater Press' The Seven Teaching Stories, Katherena Vermette.

Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science. About the Editor Brian Henderson, Division of Infection and Immunity, University College London, London, UK