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Of the three organizers of this NATO Advanced Research Workshop on
"Neocortex: Onto geny and Phylogeny," one derived most of his
knowledge about neocortex from studies on birds, another had never
studied any animal but the cat and could probably recognize not
more than ten animal species, and the third had very limited
experience with mountaineering. They had in common the belief that
evolutionary thinking permeates what biologists do, but that
evolution of species and structures cannot be directly
experimentally addressed. Although the fossil record can provide
some major insights, the inroad to the evolution of the brain is
indirect, via comparative anatomy and developmental biology. By
identifying similarities and differences between brain structures
in the species at hand, comparative anatomy generates hypotheses of
evolutionary transformations. By understanding the rules of
morphological transformation, developmental biology can, in
principle, estimate the likelihood that a given transformation may
have actually occurred. The meeting was a way to check if this
notion is viable, by gathering together scientists from these two
fields. Standing, left to right: F. Ebner, V. Caviness, M.
Weisskopf, B. Fritszch, N. Swindale, J. Walter, H. Karten, J.
Pettigrew, E. Welker, M. Cynader, D. Frost, L. Lopez-Mascaraque, P.
Katz, H. Jerison, E. Soriano, Mayor of Alagna, Dr. G. Guglielmina,
and associate, H. Van der Loos, B. Finlay, H. Scheich, C. Ruela.
Seated: S. Pallas, T. Lohmann, J. De Carlos, F. Valverde, G.
Innocenti, M. Diamond v "Gathering" does not accurately describe
what really happened."
Development of Vision and the Pre-Visual System; S.S. Easter, Jr.,
et al. Cellular and Molecular Aspects of Photoreceptor
Differentiation; R. Adler. Embryonic Patterning of Cone Subtypes in
the Mammalian Retina; K.C. Wikler, D.L. Stull. Development of Cone
Distribution Patterns in Mammals; A. Szel, et al. Genesis of
Topographic and Cellular Diversity in the Primate Retina; P. Rakic.
Development of ON and OFF Retinal Ganglion Cell Mosaics; L.M.
Chalupa, et al. Getting to Grips with Neuronal Diversity: What is a
Neuronal Type? J.E. Cook. Glio-Neuronal Interactions in Retinal
Development; A. Reichenbach. Comparative Anatomy and Function of
Mammalian Horizontal Cells; L. Peichl, et al. Parallel Pathways of
Primate Vision: Sampling of Information in the Fourier Space by M
and P Cells; L. Peichl, et al. Parallel Pathways of Primate Vision:
Sampling of Information in the Fourier Space by M and P Cells;
L.C.L. Silveira, H.D. De Mello, Jr. Transient and Persistent Na+,
Ca2+, and Mixed-Cation Currents in Retinal Ganglion Cells; A.T.
Ishida. Synaptic Transmission Between Retinal Neurons; M. Wilson.
Scaling the Retina, Micro and Macro; B.L. Finlay, R.L. Snow.
Retinal Ganglion Cell Axonal Transport: Moving Down the Road to
Functional Connections; K.L. Moya. 5 Additional Articles. Index.
Of the three organizers of this NATO Advanced Research Workshop on
"Neocortex: Onto geny and Phylogeny," one derived most of his
knowledge about neocortex from studies on birds, another had never
studied any animal but the cat and could probably recognize not
more than ten animal species, and the third had very limited
experience with mountaineering. They had in common the belief that
evolutionary thinking permeates what biologists do, but that
evolution of species and structures cannot be directly
experimentally addressed. Although the fossil record can provide
some major insights, the inroad to the evolution of the brain is
indirect, via comparative anatomy and developmental biology. By
identifying similarities and differences between brain structures
in the species at hand, comparative anatomy generates hypotheses of
evolutionary transformations. By understanding the rules of
morphological transformation, developmental biology can, in
principle, estimate the likelihood that a given transformation may
have actually occurred. The meeting was a way to check if this
notion is viable, by gathering together scientists from these two
fields. Standing, left to right: F. Ebner, V. Caviness, M.
Weisskopf, B. Fritszch, N. Swindale, J. Walter, H. Karten, J.
Pettigrew, E. Welker, M. Cynader, D. Frost, L. Lopez-Mascaraque, P.
Katz, H. Jerison, E. Soriano, Mayor of Alagna, Dr. G. Guglielmina,
and associate, H. Van der Loos, B. Finlay, H. Scheich, C. Ruela.
Seated: S. Pallas, T. Lohmann, J. De Carlos, F. Valverde, G.
Innocenti, M. Diamond v "Gathering" does not accurately describe
what really happened."
The vertebrate retina has a form that is closely and clearly linked
to its func tion. Though its fundamental cellular architecture is
conserved across verte brates, the retinas of individual species
show variations that are also of clear and direct functional
utility. Its accessibility, readily identifiable neuronal types,
and specialized neuronal connectivity and morphology have made it a
model system for researchers interested in the general questions of
the genet ic, molecular, and developmental control of cell type and
shape. Thus, the questions asked of the retina span virtually every
domain of neuroscientific inquiry-molecular, genetic,
developmental, behavioral, and evolutionary. Nowhere have the
interactions of these levels of analysis been more apparent and
borne more fruit than in the last several years of study of the
develop ment of the vertebrate retina. Fields of investigation have
a natural evolution, rdoving through periods of initial excitement,
of framing of questions and controversy, to periods of synthesis
and restatement of questions. The study of the development of the
vertebrate retina appeared to us to have reached such a point of
synthesis. Descriptive questions of how neurons are generated and
deployed, and ques tions of mechanism about the factors that
control the retinal neuron's type and distribution and the
conformation of its processes have been posed, and in good part
answered. Moreover, the integration of cellular accounts of
development with genetic, molecular, and whole-eye and behavioral
accounts has begun."
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