Bart de Graaff is ’n Nederlandse historikus en joernalis wat ’n besonderse belangstelling in die Suid-Afrikaanse politiek en kultuur het. In 2015 en 2016 het hy verskeie besoeke aan Suid-Afrika en Namibie gebring. Sy oogmerk was om die nasate van die Khoi-Khoin, synde die eerste “ware mense” van die subkontinent, op te spoor, en aan die woord te stel. Hierdie boek is die resultaat van sy onderhoude. De Graaff kontekstualiseer nie net die geskiedenis van die Khoi-Khoin en haar vele vertakkings nie, maar stel ook bepaalde eietydse leiersfigure in die onderskeie gemeenskappe aan die woord. Daarvolgens word die historiese kyk na legendariese kapteins soos die Korannas se Goliat Yzerbek, die Griekwas se Adam Kok, die Basters se Dirk Vilander, Abraham Swartbooi van die Namas en Frederik Vleermuis van die Oorlams afgewissel met De Graaff se persoonlike reisindrukke en die talle gesprekke wat hy met die waarskynlike nasate van bogenoemde leiers gehad het. In sy onopgesmukte skryfstyl, vol deernis en humor, vertel De Graaff van hierdie ontmoetings en gesprekke en algaande kom die leser onder die indruk van die sistemiese geweld wat teen die Khoi-Khoin oor soveel eeue heen gepleeg is. Dit is ’n belangrike boek wat die geskiedenis en huidige stand van die bruin mense onder hulle landsgenote se aandag bring.

From household appliances to applications in robotics, engineered systems involving complex dynamics can only be as effective as the algorithms that control them. While Dynamic Programming (DP) has provided researchers with a way to optimally solve decision and control problems involving complex dynamic systems, its practical value was limited by algorithms that lacked the capacity to scale up to realistic problems. However, in recent years, dramatic developments in Reinforcement Learning (RL), the model-free counterpart of DP, changed our understanding of what is possible. Those developments led to the creation of reliable methods that can be applied even when a mathematical model of the system is unavailable, allowing researchers to solve challenging control problems in engineering, as well as in a variety of other disciplines, including economics, medicine, and artificial intelligence. Reinforcement Learning and Dynamic Programming Using Function Approximators provides a comprehensive and unparalleled exploration of the field of RL and DP. With a focus on continuous-variable problems, this seminal text details essential developments that have substantially altered the field over the past decade. In its pages, pioneering experts provide a concise introduction to classical RL and DP, followed by an extensive presentation of the state-of-the-art and novel methods in RL and DP with approximation. Combining algorithm development with theoretical guarantees, they elaborate on their work with illustrative examples and insightful comparisons. Three individual chapters are dedicated to representative algorithms from each of the major classes of techniques: value iteration, policy iteration, and policy search. The features and performance of these algorithms are highlighted in extensive experimental studies on a range of control applications. The recent development of applications involving complex systems has led to a surge of interest in RL and DP methods and the subsequent need for a quality resource on the subject. For graduate students and others new to the field, this book offers a thorough introduction to both the basics and emerging methods. And for those researchers and practitioners working in the fields of optimal and adaptive control, machine learning, artificial intelligence, and operations research, this resource offers a combination of practical algorithms, theoretical analysis, and comprehensive examples that they will be able to adapt and apply to their own work. Access the authors' website at www.dcsc.tudelft.nl/rlbook/ for additional material, including computer code used in the studies and information concerning new developments.

This book explores the conundrum that political fortune is dependent both on social order and big, constitutive crime. An act of outrageous harm depends on rules and protocols of crime scene discovery and forensic recovery, but political authorities review events for a social agenda, so that crime is designated according to the relative absence or presence of politics. In investigating this problem, the book introduces the concepts 'intelligence crime' and 'critical forensics.' It also reviews as an exemplar of this phenomenon 'apex crime,' a watershed event involving government in the support of a contested political and social order and its primary opponent as the obvious offender, which is then subject to a confirmation bias. Chapters feature case study analysis of a selection of familiar, high profile crimes in which the motives and actions of security or intelligence actors are considered as blurred or smeared depending on their interconnection in transactional political events, or according to friend/enemy status.

This book explores the conundrum that political fortune is dependent both on social order and big, constitutive crime. An act of outrageous harm depends on rules and protocols of crime scene discovery and forensic recovery, but political authorities review events for a social agenda, so that crime is designated according to the relative absence or presence of politics. In investigating this problem, the book introduces the concepts 'intelligence crime' and 'critical forensics.' It also reviews as an exemplar of this phenomenon 'apex crime,' a watershed event involving government in the support of a contested political and social order and its primary opponent as the obvious offender, which is then subject to a confirmation bias. Chapters feature case study analysis of a selection of familiar, high profile crimes in which the motives and actions of security or intelligence actors are considered as blurred or smeared depending on their interconnection in transactional political events, or according to friend/enemy status.

This book contributes to making urban rail transport fast, punctual and energy-efficient -significant factors in the importance of public transportation systems to economic, environmental and social requirements at both municipal and national levels. It proposes new methods for shortening passenger travel times and for reducing energy consumption, addressing two major topics: (1) train trajectory planning: the authors derive a nonlinear model for the operation of trains and present several approaches for calculating optimal and energy-efficient trajectories within a given schedule; and (2) train scheduling: the authors develop a train scheduling model for urban rail systems and optimization approaches with which to balance total passenger travel time with energy efficiency and other costs to the operator. Mixed-integer linear programming and pseudospectral methods are among the new methods proposed for single- and multi-train systems for the solution of the nonlinear trajectory planning problem which involves constraints such as varying speed restrictions and maximum traction/braking force. Signaling systems and their effects are also accounted for in the trajectory planning model.Origin-destination passenger demand is included in the model formulation for train scheduling. Iterative convex programming and efficient bi-level approaches are utilized in the solution of the train-scheduling problem. In addition, the splitting rates and route choices of passengers are also optimized from the system point of view. The problems and solutions described in Optimal Trajectory Planning and Train Scheduling for Urban Rail Transit Systems will interest researchers studying public transport systems and logistics whether from an academic or practitioner background as well as providing a real application for anybody studying optimization theory and predictive control.

This book gives an introduction to the field of Incidence Geometry by discussing the basic families of point-line geometries and introducing some of the mathematical techniques that are essential for their study. The families of geometries covered in this book include among others the generalized polygons, near polygons, polar spaces, dual polar spaces and designs. Also the various relationships between these geometries are investigated. Ovals and ovoids of projective spaces are studied and some applications to particular geometries will be given. A separate chapter introduces the necessary mathematical tools and techniques from graph theory. This chapter itself can be regarded as a self-contained introduction to strongly regular and distance-regular graphs. This book is essentially self-contained, only assuming the knowledge of basic notions from (linear) algebra and projective and affine geometry. Almost all theorems are accompanied with proofs and a list of exercises with full solutions is given at the end of the book. This book is aimed at graduate students and researchers in the fields of combinatorics and incidence geometry.

This book contributes to making urban rail transport fast, punctual and energy-efficient -significant factors in the importance of public transportation systems to economic, environmental and social requirements at both municipal and national levels. It proposes new methods for shortening passenger travel times and for reducing energy consumption, addressing two major topics: (1) train trajectory planning: the authors derive a nonlinear model for the operation of trains and present several approaches for calculating optimal and energy-efficient trajectories within a given schedule; and (2) train scheduling: the authors develop a train scheduling model for urban rail systems and optimization approaches with which to balance total passenger travel time with energy efficiency and other costs to the operator. Mixed-integer linear programming and pseudospectral methods are among the new methods proposed for single- and multi-train systems for the solution of the nonlinear trajectory planning problem which involves constraints such as varying speed restrictions and maximum traction/braking force. Signaling systems and their effects are also accounted for in the trajectory planning model.Origin-destination passenger demand is included in the model formulation for train scheduling. Iterative convex programming and efficient bi-level approaches are utilized in the solution of the train-scheduling problem. In addition, the splitting rates and route choices of passengers are also optimized from the system point of view. The problems and solutions described in Optimal Trajectory Planning and Train Scheduling for Urban Rail Transit Systems will interest researchers studying public transport systems and logistics whether from an academic or practitioner background as well as providing a real application for anybody studying optimization theory and predictive control.

This book constitutes the refereed proceedings of the 15th IFIP TC 6/TC 11 International Conference on Communications and Multimedia Security, CMS 2014, held in Aveiro, Portugal, in September 2014. The 4 revised full papers presented together with 6 short papers, 3 extended abstracts describing the posters that were discussed at the conference, and 2 keynote talks were carefully reviewed and selected from 22 submissions. The papers are organized in topical sections on vulnerabilities and threats, identification and authentification, applied security.

This book constitutes the refereed proceedings of the 14th IFIP TC 6/TC 11 International Conference on Communications and Multimedia Security, CMS 2013, held in Magdeburg, Germany, in September 2013. The 5 revised full papers presented together with 11 short papers, 5 extended abstracts describing the posters that were discussed at the conference, and 2 keynote talks were carefully reviewed and selected from 30 submissions. The papers are organized in topical sections on biometrics; applied cryptography; digital watermarking, steganography and forensics; and social network privacy, security and authentication.

The first Annual Working Conference ofWG11.4oftheInter nationalFederationforInformation Processing (IFIP),focuseson variousstate of the art concepts in the field of Network and Dis tributedSystemsSecurity. Oursocietyisrapidly evolvingand irreversibly set onacourse governedby electronicinteractions. Wehave seen thebirthofe mail in the early seventies, and are now facing new challenging applicationssuchase commerce, e government,...Themoreour societyrelies on electronicforms ofcommunication,themorethe securityofthesecommunicationnetworks isessentialforitswell functioning. Asaconsequence,researchonmethodsandtechniques toimprove network security iso fparam ount importance. ThisWorking Conference bringstogetherresearchersandprac tionersofvariousdisciplines,organisationsandcountries,todiscuss thelatestdevelopmentsinsecurity protocols, secure software engin eering,mobileagentsecurity,e commercesecurityandsecurityfor distributedcomputing. Wearealsopleasedtohaveattractedtwointernationalspeakers topresenttwo case studies,one dealing withBelgium'sintentionto replacetheidentity card ofitscitizensbyanelectronicversion,and theotherdiscussingtheimplicationsofthesecuritycertificationin amultinationalcorporation. ThisWorking Conference s houldalsobeconsideredasthekick off activity ofWG11.4, the aimsof which can be summarizedas follows: topromoteresearch on technical measures forsecuringcom puternetworks, including bothhardware andsoftware based techniques. to promote dissemination of research results in the field of network security in real lifenetworks in industry, academia and administrative ins titutions. viii topromoteeducationintheapplicationofsecuritytechniques, andtopromotegeneral awarenessa boutsecurityproblems in thebroadfieldofinformationtechnology. Researchers and practioners who want to get involved in this Working Group, are kindlyrequestedtocontactthechairman. MoreinformationontheworkingsofWG11.4isavailable from the officialIFIP website:http://www.ifip.at.org/. Finally,wewish toexpressour gratitudetoallthosewho have contributedtothisconference in one wayoranother. Wearegr ate fultothe internationalrefereeboard whoreviewedallthe papers andtotheauthorsandinvitedspeakers,whosecontributionswere essential to the successof the conference. We would alsoliketo thanktheparticipantswhosepresenceand interest, togetherwith thechangingimperativesofsociety,willprovea drivingforce for futureconferencestocome.

This book constitutes the refereed proceedings of the 13th IFIP TC 6/TC 11 International Conference on Communications and Multimedia Security, CMS 2012, held in Canterbury, UK, in September 2012. The 6 revised full papers presented together with 8 short papers, 8 extended abstracts describing the posters that were discussed at the conference, and 2 keynote talks were carefully reviewed and selected from 43 submissions. The papers are organized in topical sections on image and handwriting analysis, authentication and performance, biometrics, forensics and watermarking, and communications security.

ThediscoveryofmicroRNAshasrevealedanunexpectedandspectacularadditional levelof?netuningofthegenomeandhowgenesareusedagainandagainin differentcombinationstogeneratethecomplexitythatunderliesforinstancethe brain. SincetheinitialstudiesperformedinC. elegans,wegavegoneafarwayto begintounderstandhowmicroRNApathwayscanhaveanimpactonhealthand diseaseinhuman. AlthoughmicroRNAsareabundantlyexpressedinthebrain, relativelylittleisknownaboutthemultiplefunctionsoftheseRNAmoleculesinthe nervous system. Nevertheless,we knowalready that microRNA pathways play majorrolesintheproliferation,differentiation,functionandmaintenanceofneu- nalcells. SeveralintriguingstudieshavelinkedmicroRNAsasmajorregulatorsof theneuronalphenotype,andhaveimplicatedspeci?cmicroRNAsintheregulation ofsynapseformationandplasticity. DysfunctionofmicroRNApathwaysisalso slowlyemergingasapotentialimportantcontributortothepathogenesisofmajor neurodegenerativedisorderssuchasAlzheimer'sdiseaseandParkinson'sdisease. Thesenovelinsightsappeartobeparticularpromisingfortheunderstandingofthe veryfrequentandbadlyunderstoodsporadicformsofthesediseasesascomparedto thegeneticforms. Thus,thebetterunderstandingoftheimplicationsofthisnovel ?eldofmolecularbiologyiscrucialforthebroadareaofneurosciences,fromthe fundamentalaspectstotheclinic,andfromnoveldiagnostictopotentiallythe- peuticapplicationsforsevereneurologicalandmaybepsychiatricdiseases. The presentvolumegatherscontributionstotheColloqueMe'decineetRechercheonthe implicationsofmicroRNAsinneuroscienceorganizedbytheFondationIpsen,in Paris,onApril20,2009. Ithadasobjectivetobringtogetherneuroscientistsfrom differentareasofresearchtodiscusstheircurrentinsightsintothewonderfulworld ofmicroRNAs,andtohearanddiscusstheirresearchandviewsaboutmicroRNA biologyinneuronalprocessesandinbraindisorders. BartdeStrooper YvesChristen v Acknowledgments The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the organizationofthemeetingandMaryLynnGagefortheeditingofthebook. vii Contents Pro?lingthemicroRNAs ...1 KennethS. Kosik,ThalesPapagiannakopoulos,NaXu, KawtherAbu-Elneel,TsunglinLiu,andMinJeongKye TheWideVarietyofmiRNAExpressionPro?les intheDevelopingandMatureCNS ...9 MarikaKapsimali InteractionsbetweenmicroRNAsandTranscription FactorsintheDevelopmentandFunction oftheNervousSystem ...19 DavidJ. Simon AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons ...27 AsaAbeliovich Fine-tuningmRNATranslationatSynapseswithmicroRNAs ...35 GerhardM. Schratt NeuronalP-bodiesandTransportofmicroRNA-Repressed mRNAs ...4 5 FlorenceRage CrosstalkbetweenmicroRNAandEpigeneticRegulation inStemCells ...57 KeithSzulwach,ShuangChang,andPengJin microRNAsinCNSDevelopmentandNeurodegeneration: InsightsfromDrosophilaGenetics ...69 StephenM. Cohen ix x Contents DrosophilaasaModelforNeurodegenerativeDisease: RolesofRNAPathwaysinPathogenesis ...79 NancyM. Bonini microRNAsinSporadicAlzheimer'ThediscoveryofmicroRNAshasrevealedanunexpectedandspectacularadditional levelof?netuningofthegenomeandhowgenesareusedagainandagainin differentcombinationstogeneratethecomplexitythatunderliesforinstancethe brain. SincetheinitialstudiesperformedinC. elegans,wegavegoneafarwayto begintounderstandhowmicroRNApathwayscanhaveanimpactonhealthand diseaseinhuman. AlthoughmicroRNAsareabundantlyexpressedinthebrain, relativelylittleisknownaboutthemultiplefunctionsoftheseRNAmoleculesinthe nervous system. Nevertheless,we knowalready that microRNA pathways play majorrolesintheproliferation,differentiation,functionandmaintenanceofneu- nalcells. SeveralintriguingstudieshavelinkedmicroRNAsasmajorregulatorsof theneuronalphenotype,andhaveimplicatedspeci?cmicroRNAsintheregulation ofsynapseformationandplasticity. DysfunctionofmicroRNApathwaysisalso slowlyemergingasapotentialimportantcontributortothepathogenesisofmajor neurodegenerativedisorderssuchasAlzheimer'sdiseaseandParkinson'sdisease. Thesenovelinsightsappeartobeparticularpromisingfortheunderstandingofthe veryfrequentandbadlyunderstoodsporadicformsofthesediseasesascomparedto thegeneticforms. Thus,thebetterunderstandingoftheimplicationsofthisnovel ?eldofmolecularbiologyiscrucialforthebroadareaofneurosciences,fromthe fundamentalaspectstotheclinic,andfromnoveldiagnostictopotentiallythe- peuticapplicationsforsevereneurologicalandmaybepsychiatricdiseases. The presentvolumegatherscontributionstotheColloqueMe'decineetRechercheonthe implicationsofmicroRNAsinneuroscienceorganizedbytheFondationIpsen,in Paris,onApril20,2009. Ithadasobjectivetobringtogetherneuroscientistsfrom differentareasofresearchtodiscusstheircurrentinsightsintothewonderfulworld ofmicroRNAs,andtohearanddiscusstheirresearchandviewsaboutmicroRNA biologyinneuronalprocessesandinbraindisorders. BartdeStrooper YvesChristen v Acknowledgments The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the organizationofthemeetingandMaryLynnGagefortheeditingofthebook. vii Contents Pro? lingthemicroRNAs ...1 KennethS. Kosik,ThalesPapagiannakopoulos,NaXu, KawtherAbu-Elneel,TsunglinLiu,andMinJeongKye TheWideVarietyofmiRNAExpressionPro?les intheDevelopingandMatureCNS ...9 MarikaKapsimali InteractionsbetweenmicroRNAsandTranscription FactorsintheDevelopmentandFunction oftheNervousSystem ...19 DavidJ. Simon AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons ...27 AsaAbeliovich Fine-tuningmRNATranslationatSynapseswithmicroRNAs ...35 GerhardM. Schratt NeuronalP-bodiesandTransportofmicroRNA-Repressed mRNAs ...45 FlorenceRage CrosstalkbetweenmicroRNAandEpigeneticRegulation inStemCells ...57 KeithSzulwach,ShuangChang,andPengJin microRNAsinCNSDevelopmentandNeurodegeneration: InsightsfromDrosophilaGenetics ...69 StephenM. Cohen ix x Contents DrosophilaasaModelforNeurodegenerativeDisease: RolesofRNAPathwaysinPathogenesis ...79 NancyM. Bonini microRNAsinSporadicAlzheimer'sDiseaseandRelated Dementias ...91 Se'bastienS. He'bert,WimMandemakers,AikateriniS. Papadopoulou, andBartDeStrooper microRNADysregulationinPsychiatricDisorders ...99 BinXu,JosephA. Gogos,andMariaKarayiorgou Index ...1 19 Contributors Abeliovich Asa Columbia University Medical Center, 630 West 168th Street, Room15-405,NewYork,NY10032,USA,aa900@columbia. edu Abu-ElneelKawther NeuroscienceResearchInstitute,DepartmentofMolecular CellularandDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA BoniniNancyM. UniversityofPennsylvania,306LeidyLaboratories,Depa- mentofBiology,Philadelphia,PA19104,USA,nbonini@sas. upenn. edu Chang Shuang Department of Human Genetics, Emory University School of Medicine,Atlanta,GA30322,USA CohenStephenM. TemasekLifeSciencesLaboratoryLimited,1ResearchLink National University of Singapore, 117604 Singapore, SINGAPORE, steve@ tll. org. sg DeStrooperBart Centerforhumangenetics,K. U. LeuvenandDepartmentof molecularanddevelopmentalgenetics,VIBLeuven,BELGIUM GogosJosephA. DepartmentofPhysiology&CellularBiophysicsandDepa- mentofNeuroscience,ColumbiaUniversity,NewYork,USA He'bert Se'bastien S. Centre de Recherche du CHUQ (CHUL), Axe Neur- ciences,Universite'Laval,De'partementdeBiologieme'dicale,2705Boul. Laurier, LocalRC-9800,Que'bec,Qc,Canada,sebastien. hebert@crchul. ulaval. ca JinPeng DepartmentofHumanGeneticsandGraduatePrograminGeneticsand MolecularBiology,EmoryUniversitySchoolofMedicine,Atlanta,GA30322, USA,pjin@genetics. emory. edu ' ' ' ' KapsimaliMarika INSERMU784,GenetiqueMoleculaireduDeveloppement, ' Ecole Normale Superieure, 46 rue d'Ulm, 75230 PARIS Cedex 05 FRANCE, kapsimal@biologie. ens. fr xi xii Contributors Karayiorgou Maria Columbia University, Department of Psychiatry, 1051 RiversideDrive,Unit#28,NewYorkNY10032,USA,mk2758@columbia. edu Kosik Kenneth S. Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, BiologyII,Room6139A,SantaBarbara,CA93106,USA,kosik@lifesci. ucsb.

This book constitutes the refereed proceedings of the 12th IFIP TC 6/TC 11 International Conference on Communications and Multimedia Security, CMS 2010, held in Ghent, Belgium, in October 2011. The 26 revised papers presented were carefully reviewed and selected from 52 submissions. The papers are organized in topical sections on usability, architecture and framework security, mobile identity management, secure hardware platforms, biometrics, multimedia security, network security and authentication.

In September 1989, a NATO Advanced Research Workshop on "Continuation and BIfurcations: NumerIcal TechnIques and Applications" was held at the Katholieke Unlversiteit Leuven, Belgium. Participants came from 10 countries in Europe and North America and were mainly from universities and research institutes. This proceedings volume contains 26 of the 38 papers which were presented at the meeting. Abstracts of most other contrIbutions are also included. The central theme of the workshop was the solution of parameter dependent nonlinear problems using numerical continuation. More specifically the aims can be stated as: to descrIbe typIcal bifurcation problems In sclentiftc, engineering and industrial problems; to discuss current mathematical ideas and new developments in numerical analysis and numerical techniques and to describe and evaluate program packages and to discuss future needs with respect to software. The interests of the participants extended over the complete spectrum of theory, numerical analysis, software and applications, and this spread is reflected both in the composition of this volume and in several of the papers. For example, there are contributions on the application of Centre ManIfold and Uapunov Schmidt theory to derive low dimensional systems which can be analysed by normal form theory for dynamical systems or singularIty theory."

Dormancy is a suspension of the vital functions in an organism to overcome harsh environmental conditions, and sometimes can last for centuries. It is a widespread adaptation in many phyla, ranging from bacteria to vertebrates, and may exert a great influence on aquatic communities.

Contributors to this new book are leaders in the field of diapause studies, and many authors were participants at a recent workshop on diapause in aquatic invertebrates (Pallanza, Italy 2003). The book consists of two major parts, as indicated in its title: Phenomenology of diapause and significance of this adaptation in scientific and practical uses. Application to newly developing areas such as cultivation of live food, like rotifers or Artemia, in modern aquaculture is covered, as are aspects of diapause that promote the colonization of new environments by facilitating the passive transport of resting stages of invasive species. Creation of artificial ecosystems outside of the Earth s biosphere using dormant propagules becomes an actual possibility as humankind develops plans to colonize our nearest planets. Also, studies on the vertical distribution of resting stages in undisturbed sediment cores yield important ecological and evolutionary information useful in investigations of past environments.

Throughout the book properties of diapause and individual peculiarities of this ancient and well-developed adaptive phenomenon are regarded in evolutionarily distant groups such as Rotifers, Crustaceans and Insects."

Many problems in decision making, monitoring, fault detection, and control require the knowledge of state variables and time-varying parameters that are not directly measured by sensors. In such situations, observers, or estimators, can be employed that use the measured input and output signals along with a dynamic model of the system in order to estimate the unknown states or parameters. An essential requirement in designing an observer is to guarantee the convergence of the estimates to the true values or at least to a small neighborhood around the true values. However, for nonlinear, large-scale, or time-varying systems, the design and tuning of an observer is generally complicated and involves large computational costs. This book provides a range of methods and tools to design observers for nonlinear systems represented by a special type of a dynamic nonlinear model -- the Takagi--Sugeno (TS) fuzzy model. The TS model is a convex combination of affine linear models, which facilitates its stability analysis and observer design by using effective algorithms based on Lyapunov functions and linear matrix inequalities. Takagi--Sugeno models are known to be universal approximators and, in addition, a broad class of nonlinear systems can be exactly represented as a TS system. Three particular structures of large-scale TS models are considered: cascaded systems, distributed systems, and systems affected by unknown disturbances. The reader will find in-depth theoretic analysis accompanied by illustrative examples and simulations of real-world systems. Stability analysis of TS fuzzy systems is addressed in detail. The intended audience are graduate students and researchers both from academia and industry. For newcomers to the field, the book provides a concise introduction dynamic TS fuzzy models along with two methods to construct TS models for a given nonlinear system

Over the last decade, we have witnessed a growing dependency on information technologyresultingina wide rangeofnew opportunities. Clearly, ithas become almost impossible to imagine life without a personal computer or laptop, or without a cell phone. Social network sites (SNS) are competing with face-- face encounters and may even oust them. Most SNS-adepts have hundreds of "friends," happily sharing pictures and pro?les and endless chitchat. We are on the threshold of the Internet of Things, where every object will have its RFID-tag. This will not only e?ect companies, who will be able to optimize their production and delivery processes, but also end users, who will be able to enjoy many new applications, ranging from smart shopping, and smart fridges to geo-localized services. In the near future, elderly people will be able to stay longer at home due to clever health monitoring systems. The sky seems to be the limit However, we have also seen the other side of the coin: viruses, Trojan horses, breaches of privacy, identity theft, and other security threats. Our real and virtual worlds are becoming increasingly vulnerable to attack. In order to encouragesecurity researchby both academia and industry and to stimulate the dissemination of results, conferences need to be organized. With the 11th edition of the joint IFIP TC-6 TC-11 Conference on C- munications and Multimedia Security (CMS 2010), the organizers resumed the tradition of previous CMS conferences after a three-year recess.

ThediscoveryofmicroRNAshasrevealedanunexpectedandspectacularadditional levelof?netuningofthegenomeandhowgenesareusedagainandagainin differentcombinationstogeneratethecomplexitythatunderliesforinstancethe brain. SincetheinitialstudiesperformedinC. elegans,wegavegoneafarwayto begintounderstandhowmicroRNApathwayscanhaveanimpactonhealthand diseaseinhuman. AlthoughmicroRNAsareabundantlyexpressedinthebrain, relativelylittleisknownaboutthemultiplefunctionsoftheseRNAmoleculesinthe nervous system. Nevertheless,we knowalready that microRNA pathways play majorrolesintheproliferation,differentiation,functionandmaintenanceofneu- nalcells. SeveralintriguingstudieshavelinkedmicroRNAsasmajorregulatorsof theneuronalphenotype,andhaveimplicatedspeci?cmicroRNAsintheregulation ofsynapseformationandplasticity. DysfunctionofmicroRNApathwaysisalso slowlyemergingasapotentialimportantcontributortothepathogenesisofmajor neurodegenerativedisorderssuchasAlzheimer'sdiseaseandParkinson'sdisease. Thesenovelinsightsappeartobeparticularpromisingfortheunderstandingofthe veryfrequentandbadlyunderstoodsporadicformsofthesediseasesascomparedto thegeneticforms. Thus,thebetterunderstandingoftheimplicationsofthisnovel ?eldofmolecularbiologyiscrucialforthebroadareaofneurosciences,fromthe fundamentalaspectstotheclinic,andfromnoveldiagnostictopotentiallythe- peuticapplicationsforsevereneurologicalandmaybepsychiatricdiseases. The presentvolumegatherscontributionstotheColloqueMe'decineetRechercheonthe implicationsofmicroRNAsinneuroscienceorganizedbytheFondationIpsen,in Paris,onApril20,2009. Ithadasobjectivetobringtogetherneuroscientistsfrom differentareasofresearchtodiscusstheircurrentinsightsintothewonderfulworld ofmicroRNAs,andtohearanddiscusstheirresearchandviewsaboutmicroRNA biologyinneuronalprocessesandinbraindisorders. BartdeStrooper YvesChristen v Acknowledgments The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the organizationofthemeetingandMaryLynnGagefortheeditingofthebook. vii Contents Pro?lingthemicroRNAs ...1 KennethS. Kosik,ThalesPapagiannakopoulos,NaXu, KawtherAbu-Elneel,TsunglinLiu,andMinJeongKye TheWideVarietyofmiRNAExpressionPro?les intheDevelopingandMatureCNS ...9 MarikaKapsimali InteractionsbetweenmicroRNAsandTranscription FactorsintheDevelopmentandFunction oftheNervousSystem ...19 DavidJ. Simon AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons ...27 AsaAbeliovich Fine-tuningmRNATranslationatSynapseswithmicroRNAs ...35 GerhardM. Schratt NeuronalP-bodiesandTransportofmicroRNA-Repressed mRNAs ...4 5 FlorenceRage CrosstalkbetweenmicroRNAandEpigeneticRegulation inStemCells ...57 KeithSzulwach,ShuangChang,andPengJin microRNAsinCNSDevelopmentandNeurodegeneration: InsightsfromDrosophilaGenetics ...69 StephenM. Cohen ix x Contents DrosophilaasaModelforNeurodegenerativeDisease: RolesofRNAPathwaysinPathogenesis ...79 NancyM. Bonini microRNAsinSporadicAlzheimer'ThediscoveryofmicroRNAshasrevealedanunexpectedandspectacularadditional levelof?netuningofthegenomeandhowgenesareusedagainandagainin differentcombinationstogeneratethecomplexitythatunderliesforinstancethe brain. SincetheinitialstudiesperformedinC. elegans,wegavegoneafarwayto begintounderstandhowmicroRNApathwayscanhaveanimpactonhealthand diseaseinhuman. AlthoughmicroRNAsareabundantlyexpressedinthebrain, relativelylittleisknownaboutthemultiplefunctionsoftheseRNAmoleculesinthe nervous system. Nevertheless,we knowalready that microRNA pathways play majorrolesintheproliferation,differentiation,functionandmaintenanceofneu- nalcells. SeveralintriguingstudieshavelinkedmicroRNAsasmajorregulatorsof theneuronalphenotype,andhaveimplicatedspeci?cmicroRNAsintheregulation ofsynapseformationandplasticity. DysfunctionofmicroRNApathwaysisalso slowlyemergingasapotentialimportantcontributortothepathogenesisofmajor neurodegenerativedisorderssuchasAlzheimer'sdiseaseandParkinson'sdisease. Thesenovelinsightsappeartobeparticularpromisingfortheunderstandingofthe veryfrequentandbadlyunderstoodsporadicformsofthesediseasesascomparedto thegeneticforms. Thus,thebetterunderstandingoftheimplicationsofthisnovel ?eldofmolecularbiologyiscrucialforthebroadareaofneurosciences,fromthe fundamentalaspectstotheclinic,andfromnoveldiagnostictopotentiallythe- peuticapplicationsforsevereneurologicalandmaybepsychiatricdiseases. The presentvolumegatherscontributionstotheColloqueMe'decineetRechercheonthe implicationsofmicroRNAsinneuroscienceorganizedbytheFondationIpsen,in Paris,onApril20,2009. Ithadasobjectivetobringtogetherneuroscientistsfrom differentareasofresearchtodiscusstheircurrentinsightsintothewonderfulworld ofmicroRNAs,andtohearanddiscusstheirresearchandviewsaboutmicroRNA biologyinneuronalprocessesandinbraindisorders. BartdeStrooper YvesChristen v Acknowledgments The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the organizationofthemeetingandMaryLynnGagefortheeditingofthebook. vii Contents Pro? lingthemicroRNAs ...1 KennethS. Kosik,ThalesPapagiannakopoulos,NaXu, KawtherAbu-Elneel,TsunglinLiu,andMinJeongKye TheWideVarietyofmiRNAExpressionPro?les intheDevelopingandMatureCNS ...9 MarikaKapsimali InteractionsbetweenmicroRNAsandTranscription FactorsintheDevelopmentandFunction oftheNervousSystem ...19 DavidJ. Simon AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons ...27 AsaAbeliovich Fine-tuningmRNATranslationatSynapseswithmicroRNAs ...35 GerhardM. Schratt NeuronalP-bodiesandTransportofmicroRNA-Repressed mRNAs ...45 FlorenceRage CrosstalkbetweenmicroRNAandEpigeneticRegulation inStemCells ...57 KeithSzulwach,ShuangChang,andPengJin microRNAsinCNSDevelopmentandNeurodegeneration: InsightsfromDrosophilaGenetics ...69 StephenM. Cohen ix x Contents DrosophilaasaModelforNeurodegenerativeDisease: RolesofRNAPathwaysinPathogenesis ...79 NancyM. Bonini microRNAsinSporadicAlzheimer'sDiseaseandRelated Dementias ...91 Se'bastienS. He'bert,WimMandemakers,AikateriniS. Papadopoulou, andBartDeStrooper microRNADysregulationinPsychiatricDisorders ...99 BinXu,JosephA. Gogos,andMariaKarayiorgou Index ...1 19 Contributors Abeliovich Asa Columbia University Medical Center, 630 West 168th Street, Room15-405,NewYork,NY10032,USA,aa900@columbia. edu Abu-ElneelKawther NeuroscienceResearchInstitute,DepartmentofMolecular CellularandDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA BoniniNancyM. UniversityofPennsylvania,306LeidyLaboratories,Depa- mentofBiology,Philadelphia,PA19104,USA,nbonini@sas. upenn. edu Chang Shuang Department of Human Genetics, Emory University School of Medicine,Atlanta,GA30322,USA CohenStephenM. TemasekLifeSciencesLaboratoryLimited,1ResearchLink National University of Singapore, 117604 Singapore, SINGAPORE, steve@ tll. org. sg DeStrooperBart Centerforhumangenetics,K. U. LeuvenandDepartmentof molecularanddevelopmentalgenetics,VIBLeuven,BELGIUM GogosJosephA. DepartmentofPhysiology&CellularBiophysicsandDepa- mentofNeuroscience,ColumbiaUniversity,NewYork,USA He'bert Se'bastien S. Centre de Recherche du CHUQ (CHUL), Axe Neur- ciences,Universite'Laval,De'partementdeBiologieme'dicale,2705Boul. Laurier, LocalRC-9800,Que'bec,Qc,Canada,sebastien. hebert@crchul. ulaval. ca JinPeng DepartmentofHumanGeneticsandGraduatePrograminGeneticsand MolecularBiology,EmoryUniversitySchoolofMedicine,Atlanta,GA30322, USA,pjin@genetics. emory. edu ' ' ' ' KapsimaliMarika INSERMU784,GenetiqueMoleculaireduDeveloppement, ' Ecole Normale Superieure, 46 rue d'Ulm, 75230 PARIS Cedex 05 FRANCE, kapsimal@biologie. ens. fr xi xii Contributors Karayiorgou Maria Columbia University, Department of Psychiatry, 1051 RiversideDrive,Unit#28,NewYorkNY10032,USA,mk2758@columbia. edu Kosik Kenneth S. Neuroscience Research Institute, Department of Molecular Cellular and Developmental Biology, University of California Santa Barbara, BiologyII,Room6139A,SantaBarbara,CA93106,USA,kosik@lifesci. ucsb.

Many authors of this new book were participants at the workshop on diapause in aquatic invertebrates (Pallanza, Italy 2003). The book consists of two major parts indicated in its title: Phenomenology of diapause and significance of this adaptation in scientific and practical uses. Cultivation of live food, like rotifers or Artemia is an expanding application of practical use of diapause in modern aquaculture. Diapause provides the advantage of promoting the colonization of new environments by facilitating the passive transport of the resting stages of invasive species. Creation of artificial ecosystems outside the Earth's biosphere with using dormancy becomes an actual possibility with the plans of humans to colonize our nearest planets. Studies on the vertical distribution of resting eggs in sediment cores yield important ecological information.

The first Annual Working Conference ofWG11.4oftheInter nationalFederationforInformation Processing (IFIP), focuseson variousstate of the art concepts in the field of Network and Dis tributedSystemsSecurity. Oursocietyisrapidly evolvingand irreversibly set onacourse governedby electronicinteractions. Wehave seen thebirthofe mail in the early seventies, and are now facing new challenging applicationssuchase commerce, e government, ....Themoreour societyrelies on electronicforms ofcommunication, themorethe securityofthesecommunicationnetworks isessentialforitswell functioning. Asaconsequence, researchonmethodsandtechniques toimprove network security iso fparam ount importance. ThisWorking Conference bringstogetherresearchersandprac tionersofvariousdisciplines, organisationsandcountries, todiscuss thelatestdevelopmentsinsecurity protocols, secure software engin eering, mobileagentsecurity, e commercesecurityandsecurityfor distributedcomputing. Wearealsopleasedtohaveattractedtwointernationalspeakers topresenttwo case studies, one dealing withBelgium'sintentionto replacetheidentity card ofitscitizensbyanelectronicversion, and theotherdiscussingtheimplicationsofthesecuritycertificationin amultinationalcorporation. ThisWorking Conference s houldalsobeconsideredasthekick off activity ofWG11.4, the aimsof which can be summarizedas follows: topromoteresearch on technical measures forsecuringcom puternetworks, including bothhardware andsoftware based techniques. to promote dissemination of research results in the field of network security in real lifenetworks in industry, academia and administrative ins titutions. viii topromoteeducationintheapplicationofsecuritytechniques, andtopromotegeneral awarenessa boutsecurityproblems in thebroadfieldofinformationtechnology. Researchers and practioners who want to get involved in this Working Group, are kindlyrequestedtocontactthechairman. MoreinformationontheworkingsofWG11.4isavailable from the officialIFIP website: http: //www.ifip.at.org/. Finally, wewish toexpressour gratitudetoallthosewho have contributedtothisconference in one wayoranother. Wearegr ate fultothe internationalrefereeboard whoreviewedallthe papers andtotheauthorsandinvitedspeakers, whosecontributionswere essential to the successof the conference. We would alsoliketo thanktheparticipantswhosepresenceand interest, togetherwith thechangingimperativesofsociety, willprovea drivingforce for futureconferen

The Netherlands Antilles comprises three main islands off the coast of northern Venezuela. These are Aruba, Curacao and Bonaire . They are major tourist destinations, especially popular with divers, and also attract many visitors from Holland and elsewhere. The colour plates are based on the bestselling Birds of Northern South America, but many new images have been painted specially for this book. The authoritative text highlights the key features needed to identify each species in the field, and the plates illustrate every distinct plumage and race. This will be the first ever comprehensive field guide dedicated to the birds of the region.

In Richard Deacon's solo exhibition Some Time, a refabricated version of his sculpture Never Mind takes pride of place among more than twenty-five other works. Over time, the original sculpture, made in 1993, proved to be incompatible with the natural environment of an open-air museum. Now, after a period of critical reflection and discussion with the artist himself, what he calls a 'refabrication' has taken place. Follow the artist and the museum's quest for an innovative, sustainable solution to the renewal of (or variation on) a monumental sculpture that offers a potentially new line of approach for the future. This book not only represents the Some Time exhibition, but thanks to its diversity of material, ranging from original sketches and intimate correspondence to construction photos from the workshop and installation shots, it also gives a unique insight into Deacon's working process. At the same time, it provides a moment of critical reflection from the perspectives of the various authors who have contributed to it. Text in English and Dutch.

Ivan Koaric (born 1921) is among Croatia's most significant contemporary artists; in the late 1940s he was a central figure in Yugoslavia's postwar avant-garde. Although he is renowned and influential in Croatia, this survey represents the first examination of his practice outside Croatia.