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Techniques for Downstream process for Biologic Drugs and Vaccines
provides comprehensive technologies involved in processing
postharvest broth to separate the target biological therapeutic
products of extracellular or intercellular aspects in nature - to
its highest purification form, and to thus make it acceptable to
end users. The technologies involved in the post-harvesting of
fermented broth are explained in this comprehensive resource in a
simplified manner with different case studies to help
non-engineering students and scientists easily capture the basic
principle of biomass processing technologies and their applications
in new projects related to the development and manufacturing of
therapeutic bio-products. As conceptual development of
biotechnology has taken new shape and style with the integration of
medical sciences, physical science, and engineering, and has thus
begun the need for the development of microbial or cell line
process technology and application for large-scale isolation and
purification of metabolites or vaccines through the fermentation
process, this book covers the most important aspects.
This book presents a concept for implementing a mass balance
approach toward developing an effective eco-friendly, livestock
farming system independent of external energy input. In this
context it describes a modern, integrated farming system, and
includes comprehensive technical information explaining the design
and evaluation of manure management systems, and modeling and
operational tools. It first discusses the mass balance operating
process, highlighting the difference between imported and exported
mass across the farm boundary. Estimating mass balance can provide
critical information for (comprehensive) nutrient management
planning and for managing the movement of nutrients and manure. It
then explains the estimation of whole-farm P mass balance using a
suitable model system. The subsequent chapters provide updated
information on management aspects of livestock-farming and
generation of multiple job opportunities, and also explore various
aspects of livestock farming operational protocols like housing and
management; nurture of rams, ewes and lambs, new born calves and
heifers; care of buck, doe and kid- nutrition flushing; concept
zero grazing-systems; disease control and management; integrated
goat farming; and crop-livestock integration. Further, the book
addresses crop-livestock integration; energy autonomy in cattle
farming; value added biopharmaceuticals from cattle farming; CAPEX
for cattle farming; concepts of cattle farming; detrimental effects
of the industry; topographic and edaphic factors, and thermal
stress on livestock growth and development; socioeconomic
development; and water requirements for livestock. The book
concludes with the most important issue in the field of agriculture
and veterinary science: "Livestock Farming with Care," describing
sustainable, eco-friendly livestock farming by highlighting issues
like animal feed vs. human food; agricultural GDP vs livestock, and
factors affecting the sustainability of livestock farming. Given
its scope, this book is a valuable resource for researchers and
students alike, and will also appeal to practitioners in the field
of livestock.
Tailoring of biomolecules using protein engineering technology, and
host cells culture techniques are among the most sophisticated and
elegant achievements of modern applied life sciences in which the
basic fundamentals biotechnology are applicable for the development
and manufacturing of biologics and other related bio-molecules for
a hurdle free life with good health. A majority of biologics
derived from genetically modified host cells in the current market
are bio-formulation such as antibodies, nucleic acid products and
vaccines. Such bio-formulations are developed mainly in two steps
i.e. upstream process and downstream process. The first volume of
this series begins with the latest information on how the classical
stepwise host cells culture (mammals, animals, plants, and
bacteria) methodology has been changed to fully continuous or
partially continuous host cells culture process in order to
economise the biopharmaceutical products manufacturing process. In
addition this volume narrates a brief history on conceptual
development of new thoughts in designing biotechnology industries
for commercial production of variety of therapeutic proteins with
structural modification on the basis of clinical requirements. The
readers will feel exited by going through the latest discovery and
development in applied life sciences for designing innovative
biomolecules for health care with utmost safe. The most interesting
part of this volume is newly developed concept on bioprinting. It
explains how to design and fabricate animate objects by fusing or
depositing material of interest in the form of powders, solid
dusts, metal, liquid or even living cells or tissues by layers to
produce 3D objectives. The first volume ends with the latest
information on the current trend in biologics market, market
dynamic, drives, and opportunities with challenges.
This book presents a concept for implementing a mass balance
approach toward developing an effective eco-friendly, livestock
farming system independent of external energy input. In this
context it describes a modern, integrated farming system, and
includes comprehensive technical information explaining the design
and evaluation of manure management systems, and modeling and
operational tools. It first discusses the mass balance operating
process, highlighting the difference between imported and exported
mass across the farm boundary. Estimating mass balance can provide
critical information for (comprehensive) nutrient management
planning and for managing the movement of nutrients and manure. It
then explains the estimation of whole-farm P mass balance using a
suitable model system. The subsequent chapters provide updated
information on management aspects of livestock-farming and
generation of multiple job opportunities, and also explore various
aspects of livestock farming operational protocols like housing and
management; nurture of rams, ewes and lambs, new born calves and
heifers; care of buck, doe and kid- nutrition flushing; concept
zero grazing-systems; disease control and management; integrated
goat farming; and crop-livestock integration. Further, the book
addresses crop-livestock integration; energy autonomy in cattle
farming; value added biopharmaceuticals from cattle farming; CAPEX
for cattle farming; concepts of cattle farming; detrimental effects
of the industry; topographic and edaphic factors, and thermal
stress on livestock growth and development; socioeconomic
development; and water requirements for livestock. The book
concludes with the most important issue in the field of agriculture
and veterinary science: "Livestock Farming with Care," describing
sustainable, eco-friendly livestock farming by highlighting issues
like animal feed vs. human food; agricultural GDP vs livestock, and
factors affecting the sustainability of livestock farming. Given
its scope, this book is a valuable resource for researchers and
students alike, and will also appeal to practitioners in the field
of livestock.
This book sheds new light on how microbes can be used as effective
and sustainable resources to produce green energy in the form of
biogas, algal diesel, ethanol, hydrogen and direct electricity. It
discusses topics such as microbial energy conversion technologies,
including ethanol production by microbial catalytic reaction,
biomethanization, biodiesel from microalgae, microbial fuel cells,
and the microbiological production of hydrogen. The book will
inspire scientists to find new approaches to meet local energy
demands with the help of sustainable microbial resources available
in and around a given location.
This book describes how microbes can be used as effective and
sustainable resources to meet the current challenge of finding
suitable and economical solutions for biopharmaceuticals, enzymes,
food additives, nutraceuticals, value added biochemicals and
microbial fuels, and discusses various aspects of microbial
regulatory activity and its applications. It particularly focuses
on the design, layout and other relevant issues in industrial
microbe applications. Moreover, it discusses the entire
microbial-product supply chain, from manufacturing sites to end
users, both in domestic and international markets, providing
insights into the global marketing of microbes and microbial
biomass-derived products. Further, it includes topics concerning
the effective production and utilization of eco-friendly
biotechnology industries. It offers a valuable, ready-to-use guide
for technologists and policymakers developing new biotechnologies.
This book describes how microbes can be used as effective and
sustainable resources to meet the current challenge of finding
suitable and economical solutions for biopharmaceuticals, enzymes,
food additives, nutraceuticals, value added biochemicals and
microbial fuels, and discusses various aspects of microbial
regulatory activity and its applications. It particularly focuses
on the design, layout and other relevant issues in industrial
microbe applications. Moreover, it discusses the entire
microbial-product supply chain, from manufacturing sites to end
users, both in domestic and international markets, providing
insights into the global marketing of microbes and microbial
biomass-derived products. Further, it includes topics concerning
the effective production and utilization of eco-friendly
biotechnology industries. It offers a valuable, ready-to-use guide
for technologists and policymakers developing new biotechnologies.
This book sheds new light on how microbes can be used as effective
and sustainable resources to produce green energy in the form of
biogas, algal diesel, ethanol, hydrogen and direct electricity. It
discusses topics such as microbial energy conversion technologies,
including ethanol production by microbial catalytic reaction,
biomethanization, biodiesel from microalgae, microbial fuel cells,
and the microbiological production of hydrogen. The book will
inspire scientists to find new approaches to meet local energy
demands with the help of sustainable microbial resources available
in and around a given location.
Healthcare Strategies and Planning for Social Inclusion and
Development: Volume One: Health for All - Challenges and
Opportunities in Healthcare Management examines health care
management, particularly in developing countries, along with the
key aspects of universal health required to address current global
health issues. This new volume begins with an overview of the
concept and definition of "Health for All." The book covers how
international organizations like the WHO support national health
authorities in managing their core healthcare systems, support
healthcare workforces, utilize technologies like health information
systems, ensure health coverage and funding, and provide primary
healthcare education. This volume is a useful resource to graduate
students in public health and health care policy, public health
professionals, health and social work researchers, and health
policy makers interested in global health and primary healthcare
services, particularly in developing countries.
Healthcare Strategies and Planning for Social Inclusion and
Development: Volume Two: Social, Economic, and Health Disparities
of Rural Women examines rural women, particularly in developing
countries, and how social and economic constraints they experience
impact their ability to advocate for their own health and impede
their access to healthcare. This volume discusses the economic and
social barriers rural women confront in exercising their right to
health care. It explains how geographical isolation, economic
instability, healthcare provider shortages, lack of appropriate
funding, resource limitations, and lack of health education are
just few factors that make rural health care difficult. The book
also covers the impact of social isolation on the health needs of
rural women which include chronic diseases, mental health, and
OB/GYN services as well as how the lack of opportunities for formal
education restrict rural women from working outside the household.
This volume will be a useful resource to graduate students in
public and global health, public health professionals, health and
social work researchers, and health policymakers interested in
women's health, especially in developing countries.
This book is a practical manual for goat production systems
covering: breeding and selection, feeding based on available crops
and resources, and targeted preventative health care for increased
productivity and income. It outlines best practice and strategies
for setting up a farm, overcoming challenges, increasing milk and
meat quality, obtaining sustainability, reducing environmental
pollution, optimising climatic conditions and tapping into local
know-how. In addition, the book details developing region-specific
data for effective decision making and better management, as well
as how to run a developmental project to empower stake holders for
higher production, support innovation, and analyse the supply chain
for better product quality and marketing.
Conceptual Development of Industrial Biotechnology for Commercial
Production of Biopharmaceuticals and Vaccines provides insights on
how to bring sustainability into biologic drug production. The
cumulative facts and figures within in the book are helpful to
promoters in monitoring value chain transfer process of super
quality biologics for better return in profits. In addition, this
is a useful reference for students, researchers and scientists in
biotechnology, pharmaceutical science, medical sciences, and the
R&D division of biotechnology-based industries. Conceptual
development of biotechnology has taken new avenues with the
integration of medical sciences, physical science, and engineering,
hence this is a timely source. The current global market for
vaccines, especially COVID-19, is tremendous. Bivalent oral polio
vaccine, diphtheria, tetanus-containing, and measles-containing
vaccines have a high demand internationally and recombinant DNA
technology and protein engineering are helpful in the production of
quality bio-products.
Environmental Technology and Sustainability: Physical, Chemical and
Biological Technologies for Clean Environmental Management provides
a dependable source of information on the fundamental scientific
evidence involved in environmental protection and sustainable
development. The book provides the basic natural sciences that
underpin the understanding, development and application of
environment technologies that support a clean inhabitable world
that includes environmental technologies and sustainable, renewable
energy systems. It considers the science and technology for
environmental benefits, including the development of both smarter,
cleaner technologies for environmental protection, conservation,
and more.
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