She wears her heart on her sleeve. Parting is such sweet sorrow. Something wicked this way comes! We're all familiar with these sayings. But where did they come from? Introduce young readers to the treasures of William Shakespeare with Shakespeare Illustrated Classics. Each title tells the tale of a popular play and is sure to inspire further Shakespearian study!

She wears her heart on her sleeve. Parting is such sweet sorrow. Something wicked this way comes! We're all familiar with these sayings. But where did they come from? Introduce young readers to the treasures of William Shakespeare with Shakespeare Illustrated Classics. Each title tells the tale of a popular play and is sure to inspire further Shakespearian study!

This unique book describes newly discovered proteolytic enzymes and their biological function. In many cases, these enzymes are targets for new drug discovery in order to provide new therapeutic approaches to control human diseases and/or metabolic conditions. The chapters in this book will help other investigators to pursue drug discovery by detailing methods of production and assay of the enzymes. In addition, the latest structural studies that are described in the book will permit rapid advances in drug design. The most important elements of this book are the state-of-the-art, detailed descriptions of the properties of the proteolytic enzymes. The chapters in the book, written by leading experts in the field, collect the best work on the topics with complete bibliographies for each target enzyme. The illustrations are highly informative to aid and facilitate a new design of inhibitors that can be developed as drug candidates. Key chapters include those by Mark Gorrell and Catherine Abbott, both describing dipeptidyl peptidases, which have been implicated in a number of metabolic conditions including diabetes. The chapters are written from two very different perspectives, thus enriching the literature in this area. In addition, the chapter by Sheena McGowan focuses on aminopeptidases from the malaria parasite, Plasmodium falciparum, and the chapter by Ben Dunn deals with the aspartic peptidases from the same organism.

Exclusively from Antarctic Press comes this latest addition to the top-selling "How to Draw Manga" series - a supersized book of all-new instructional material on one of the most vital aspects of manga: toning! This definitive source will show aspiring artists the secrets, skills, and techniques of manga pros for bringing line art to life; making characters charismatic and landscapes lush! Artists will surely want to tone their manga muscles with "Toning Techniques Revealed"! And now those artists can take their toning into the digital dimension with this special CD-ROM edition! With digital versions of all the pages; practice images; official, ready-to-use Antarctic Press screentone files; and more, this is the tutorial for tackling toning!