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The book is divided into two parts: Part I deals with the relevant
physics and planning algorithms of protons (H Breuer) and Part II
with the radiobiology, radiopathology and clinical outcomes of
proton therapy and a comparison of proton therapy versus photon
therapy (BJ Smit). Protons can be used for radiosurgery and general
radio therapy. Since proton therapy was first proposed in 1946 by
Wilson, about sixteen facilities have been built globally. Only a
very few of these have isocentric beam delivery systems so that
proton therapy is really only now in a position to be compared
directly by means of randomised clinical trials, with modern photon
radiotherapy therapy sys tems, both for radiosurgery and for
general fractionated radiotherapy. Three-dimensional proton
planning computer systems with image fusion (image of computerised
tomography (CT), magnetic resonance registration) capabilities
imaging (MRI), stereotactic angiograms and perhaps positron
emission tomography (PET) are essential for accurate proton therapy
planning. New planning systems for spot scanning are under
development. Many of the older comparisons of the advantageous dose
distributions for protons were made with parallel opposing or
multiple co-planar field arrangements, which are now largely
obsolete. New comparative plans are necessary once more because of
the very rapid progress in 3-D conformal planning with photons. New
cost-benefit analy ses may be needed. Low energy (about 70 MeV)
proton therapy is eminently suitable for the treatment of eye
tumours and has firmly established itself as very useful in this
regard."
The book is divided into two parts: Part I deals with the relevant
physics and planning algorithms of protons (H Breuer) and Part II
with the radiobiology, radiopathology and clinical outcomes of
proton therapy and a comparison of proton therapy versus photon
therapy (BJ Smit). Protons can be used for radiosurgery and general
radio therapy. Since proton therapy was first proposed in 1946 by
Wilson, about sixteen facilities have been built globally. Only a
very few of these have isocentric beam delivery systems so that
proton therapy is really only now in a position to be compared
directly by means of randomised clinical trials, with modern photon
radiotherapy therapy sys tems, both for radiosurgery and for
general fractionated radiotherapy. Three-dimensional proton
planning computer systems with image fusion (image of computerised
tomography (CT), magnetic resonance registration) capabilities
imaging (MRI), stereotactic angiograms and perhaps positron
emission tomography (PET) are essential for accurate proton therapy
planning. New planning systems for spot scanning are under
development. Many of the older comparisons of the advantageous dose
distributions for protons were made with parallel opposing or
multiple co-planar field arrangements, which are now largely
obsolete. New comparative plans are necessary once more because of
the very rapid progress in 3-D conformal planning with photons. New
cost-benefit analy ses may be needed. Low energy (about 70 MeV)
proton therapy is eminently suitable for the treatment of eye
tumours and has firmly established itself as very useful in this
regard."
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