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This book review series presents current trends in modern
biotechnology. The aim is to cover all aspects of this
interdisciplinary technology where knowledge, methods and expertise
are required from chemistry, biochemistry, microbiology, genetics,
chemical engineering and computer science. Volumes are organized
topically and provide a comprehensive discussion of developments in
the respective field over the past 3-5 years. The series also
discusses new discoveries and applications. Special volumes are
dedicated to selected topics which focus on new biotechnological
products and new processes for their synthesis and purification. In
general, special volumes are edited by well-known guest editors.
The series editor and publisher will however always be pleased to
receive suggestions and supplementary information. Manuscripts are
accepted in English.
The main objective of this work was to investigate the application
of experimental design techniques for the identification of
Michaelis-Menten kinetic parameters. More specifically, this study
attempts to elucidate the relative advantages/disadvantages of
employing complex experimental design techniques in relation to
equidistant sampling when applied to different reactor operation
modes. All studies were supported by simulation data of a generic
enzymatic process that obeys to the Michaelis-Menten kinetic
equation. Different aspects were investigated, such as the
influence of different reactor operation modes (batch, fed-batch
with pulsewise feeding and fed- batch with continuous feeding) and
the experimental design optimality criteria on the effectiveness of
kinetic parameters identification.
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