Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy's ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy's roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (self and microbial) antigens; it shapes central tolerance; it affects B and T cell homeostasis; it acts both as an effector and a regulator of Toll-like receptor and other innate immunity receptor signaling; and it may help ward off chronic inflammatory disease in humans. With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. This book introduces the reader to the fundamentals of autophagy, guides a novice and the well-informed reader alike through different immunological aspects of autophagy as well as the countermeasures used by highly adapted pathogens to fight autophagy, and provides the expert with the latest, up-to-date information on the specifics of the leading edge of autophagy research in infection and immunity.

Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy's ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy's roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (self and microbial) antigens; it shapes central tolerance; it affects B and T cell homeostasis; it acts both as an effector and a regulator of Toll-like receptor and other innate immunity receptor signaling; and it may help ward off chronic inflammatory disease in humans. With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. This book introduces the reader to the fundamentals of autophagy, guides a novice and the well-informed reader alike through different immunological aspects of autophagy as well as the countermeasures used by highly adapted pathogens to fight autophagy, and provides the expert with the latest, up-to-date information on the specifics of the leading edge of autophagy research in infection and immunity.

The relationship between verbs and their arguments is a widely debated topic in linguistics. This comprehensive 2005 survey provides an overview of this important area of research, exploring theories of how a verb's semantics can determine the morphosyntactic realization of its arguments. Assuming a close connection between verb meaning and syntactic structure, it provides a bridge between lexical-semantic and syntactic research, synthesizing the results of work from a range of linguistic subdisciplines and in a variety of theoretical frameworks. The first four chapters survey leading theories about event structure and conceptualization. The fifth and sixth chapters focus on the mapping from lexical semantics to morphosyntax and include a detailed discussion of the thematic hierarchy. The final chapter reviews treatments of multiple argument realization. With useful bibliographic references and clear definitions of relevant terms, this book will be invaluable to students and researchers in syntax and semantics, as well as those in related fields.

The relationship between verbs and their arguments is a widely debated topic in linguistics. This comprehensive 2005 survey provides an overview of this important area of research, exploring theories of how a verb's semantics can determine the morphosyntactic realization of its arguments. Assuming a close connection between verb meaning and syntactic structure, it provides a bridge between lexical-semantic and syntactic research, synthesizing the results of work from a range of linguistic subdisciplines and in a variety of theoretical frameworks. The first four chapters survey leading theories about event structure and conceptualization. The fifth and sixth chapters focus on the mapping from lexical semantics to morphosyntax and include a detailed discussion of the thematic hierarchy. The final chapter reviews treatments of multiple argument realization. With useful bibliographic references and clear definitions of relevant terms, this book will be invaluable to students and researchers in syntax and semantics, as well as those in related fields.

In this rich reference work, Beth Levin classifies over 3,000 English verbs according to shared meaning and behavior. Levin starts with the hypothesis that a verb's meaning influences its syntactic behavior and develops it into a powerful tool for studying the English verb lexicon. She shows how identifying verbs with similar syntactic behavior provides an effective means of distinguishing semantically coherent verb classes, and isolates these classes by examining verb behavior with respect to a wide range of syntactic alternations that reflect verb meaning. The first part of the book sets out alternate ways in which verbs can express their arguments. The second presents classes of verbs that share a kernel of meaning and explores in detail the behavior of each class, drawing on the alternations in the first part. Levin's discussion of each class and alternation includes lists of relevant verbs, illustrative examples, comments on noteworthy properties, and bibliographic references. The result is an original, systematic picture of the organization of the verb inventory. Easy to use, English Verb Classes and Alternations sets the stage for further explorations of the interface between lexical semantics and syntax. It will prove indispensable for theoretical and computational linguists, psycholinguists, cognitive scientists, lexicographers, and teachers of English as a second language. Beth Levin is associate professor of linguistics at Northwestern University.

Besides providing extensive support for David Perlmutter's hypothesis that unaccusativity is syntactically represented but semantically determined, this monograph contributes significantly to the development of a theory of lexical semantic representation and to the elucidation of the mapping from lexical semantics to syntax. Unaccusativity is an extended investigation into a set of linguistic phenomena that have received much attention over the last fifteen years. Besides providing extensive support for David Perlmutter's hypothesis that unaccusativity is syntactically represented but semantically determined, this monograph contributes significantly to the development of a theory of lexical semantic representation and to the elucidation of the mapping from lexical semantics to syntax. Perlmutter's Unaccusative Hypothesis proposes that there are two classes of intransitive verbs - unergatives and unaccusatives - each associated with a distinct syntactic configuration. Unaccusativity begins by isolating the semantic factors that determine whether a verb will be unaccusative or unergative through a careful examination of the behavior of intransitive verbs from a range of semantic classes in diverse syntactic constructions. Notable are the extensive discussions of verbs of motion, verbs of emission, and various types of verbs of change of state. The authors then introduce rules that determine the syntactic expression of the arguments of the verbs investigated and examine the interactions among them. The proper treatment of verbs that systematically show multiple meanings - and hence variable classification as unaccusative or unergative - is also considered. In the final chapter, the authors argue that the distribution of locative inversion, a purported unaccusative diagnostic, is determined instead by discourse considerations. Linguistic Inquiry Monograph No. 26