This book constitutes the refereed proceedings of the 13th International Symposium on Visual Computing, ISVC 2018, held in Las Vegas, NV, USA in November 2018. The total of 66 papers presented in this volume was carefully reviewed and selected from 91 submissions. The papers are organized in topical sections named: ST: computational bioimaging; computer graphics; visual surveillance; pattern recognition; vitrual reality; deep learning; motion and tracking; visualization; object detection and recognition; applications; segmentation; and ST: intelligent transportation systems.