Sharmila Majumdar In the area of osteoporosis and skeletal changes, it is currently accepted that bone mineral density (BMD), widely used for screening, monitoring and assessing therapeutic efficacy, does not adequately explain the pathogenesis of osteoporosis, the process of aging, or the therapeutic efficacy of various treatments. In this context, trabecular micro- architecture has enormous potential to contribute to understanding the pathophysiology of osteopor.osis and therapy assessment. The use and value of noninvasive imaging and quantitative image analysis and processing of trabecular bone micro-architecture have increased dramatically due to recent advances in instrumentation and software. This emerging field is diverse, interdisciplinary, and encompasses many different imaging modalities. Interested researchers include those involved in technique development, basic science and animal studies, as well as clinical researchers and practicing physicians. With the growth of this area of research, a group of investigators at the 11th Interna- tional Workshop of Bone Densitometry, 1 concluded that a forum dedicated to this matter was urgently needed. With this agenda, Dr. Peter Ruegsegger organized the first sympo- 2 sium on conjunction with the 10th Conference of the European Society of Biomechanics. The symposium on Bone Architecture and Competence was a two-hourlong event which resulted in five chapters in Bone Research and Biomechanics, edited by G. Lowet, P. Ruegsegger, H. Weinans, and A. Meunier, published by lOS Press, 1997. The second symposium was held as a pre-symposium to the 12th Workshop on Bone Denistometry,3 and flourished as a daylong event.

Sharmila Majumdar In the area of osteoporosis and skeletal changes, it is currently accepted that bone mineral density (BMD), widely used for screening, monitoring and assessing therapeutic efficacy, does not adequately explain the pathogenesis of osteoporosis, the process of aging, or the therapeutic efficacy of various treatments. In this context, trabecular micro- architecture has enormous potential to contribute to understanding the pathophysiology of osteopor.osis and therapy assessment. The use and value of noninvasive imaging and quantitative image analysis and processing of trabecular bone micro-architecture have increased dramatically due to recent advances in instrumentation and software. This emerging field is diverse, interdisciplinary, and encompasses many different imaging modalities. Interested researchers include those involved in technique development, basic science and animal studies, as well as clinical researchers and practicing physicians. With the growth of this area of research, a group of investigators at the 11th Interna- tional Workshop of Bone Densitometry, 1 concluded that a forum dedicated to this matter was urgently needed. With this agenda, Dr. Peter Ruegsegger organized the first sympo- 2 sium on conjunction with the 10th Conference of the European Society of Biomechanics. The symposium on Bone Architecture and Competence was a two-hourlong event which resulted in five chapters in Bone Research and Biomechanics, edited by G. Lowet, P. Ruegsegger, H. Weinans, and A. Meunier, published by lOS Press, 1997. The second symposium was held as a pre-symposium to the 12th Workshop on Bone Denistometry,3 and flourished as a daylong event.

In the year 2047, Mitchell Hughes, a visually impaired divorced schoolteacher with two young children, is on trial for murder. The only eyewitness to the murder is a poly-gig micro-tronic computer chip implanted deep within the brain of every United States citizen. This computerized chip implant is known as the DuoDrite. The DuoDrite chip implant is engineered as the first transmitter and receiver for communications and entertainment, replacing personal computers, global positioning systems, cellular telephones, and home entertainment devices. The DuoDrite technology is the sole interface to the Internet and is simply accessed by thought and visualization in the mind's eye. Since the DuoDrite chip implant's first conception in 2015, government agencies, such as the Department of Homeland Security, discovered its uses as a measure to protect national security. The Memory Data File, or MDF, is the primary tool used by law enforcement. Once a crime is committed, the DuoDrite chip immediately transfers the MDF of the crime to the appropriate law enforcement agency. Mitchell Hughes is accused by his very own MDF of a capital crime. It is up to Mitchell's defense attorney, Claire Evans, a woman secretly in love with her client, to save him from the clutches of a diabolical conspiracy. Mitchell Hughes discovers that he is cursed with a defect in his DuoDrite chip implant. Will Mitchell be able to overcome the defect and use the technology that he has denounced for his own preservation?

In the year 2047, Mitchell Hughes, a visually impaired divorced schoolteacher with two young children, is on trial for murder. The only eyewitness to the murder is a poly-gig micro-tronic computer chip implanted deep within the brain of every United States citizen. This computerized chip implant is known as the DuoDrite. The DuoDrite chip implant is engineered as the first transmitter and receiver for communications and entertainment, replacing personal computers, global positioning systems, cellular telephones, and home entertainment devices. The DuoDrite technology is the sole interface to the Internet and is simply accessed by thought and visualization in the mind's eye. Since the DuoDrite chip implant's first conception in 2015, government agencies, such as the Department of Homeland Security, discovered its uses as a measure to protect national security. The Memory Data File, or MDF, is the primary tool used by law enforcement. Once a crime is committed, the DuoDrite chip immediately transfers the MDF of the crime to the appropriate law enforcement agency. Mitchell Hughes is accused by his very own MDF of a capital crime. It is up to Mitchell's defense attorney, Claire Evans, a woman secretly in love with her client, to save him from the clutches of a diabolical conspiracy. Mitchell Hughes discovers that he is cursed with a defect in his DuoDrite chip implant. Will Mitchell be able to overcome the defect and use the technology that he has denounced for his own preservation?