This volume offers the most comprehensive presentation available on metal toxicology. It discusses not only metals but also the toxic endpoints, such as neurotoxicity, renal toxicity, and cancer induction. Chapters are written by experts in their respective fields, focusing on carcinogenesis and human exposures and highlighting the major aspects and issues of toxicity in general.

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers "General Considerations" and Volume II is devoted to "Specific Metals." A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.

This volume offers the most comprehensive presentation available on metal toxicology. It discusses not only metals but also the toxic endpoints, such as neurotoxicity, renal toxicity, and cancer induction. Chapters are written by experts in their respective fields, focusing on carcinogenesis and human exposures and highlighting the major aspects and issues of toxicity in general.

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice.

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA -TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication-the classic risk assessment paradigm-with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.

Electronic Waste: Toxicology and Public Health Issues discusses the major public health concerns due to the presence of toxic chemicals that are generated from improper recycling and disposal practices of electronic waste (e-waste). This book highlights hazardous inorganic chemicals found in e-waste, including arsenic, cadmium, lead, mercury, gallium, iridium, and nanomaterials, also focusing on health issues related to the presence of BPA, styrene, and other plastic components and combustion products, while also identifying populations at special risk. To provide readers with potential solutions to this global problem, Dr. Fowler presents risk assessment approaches using chemicals, mixtures, biomarkers, susceptibility factors, and computational toxicology. He discusses how to translate the information gathered through risk assessment into safe and effective international policies. The final chapter is devoted to future research directions. This is a timely and useful resource for all those concerned with the health issues surrounding e-waste management and proper disposal, including toxicologists, public health and policy officials, environmental scientists, and risk assessors.

"Computational Toxicology: Methods and Applications for Risk Assessment" is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns.
Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment informationIncorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared