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This volume offers the most comprehensive presentation available on
metal toxicology. It discusses not only metals but also the toxic
endpoints, such as neurotoxicity, renal toxicity, and cancer
induction. Chapters are written by experts in their respective
fields, focusing on carcinogenesis and human exposures and
highlighting the major aspects and issues of toxicity in general.
Handbook on the Toxicology of Metals, Fourth Edition bridges the
gap between established knowledgebase and new advances in metal
toxicology to provide one essential reference for all those
involved in the field. This book provides comprehensive coverage of
basic toxicological data, emphasizing toxic effects primarily in
humans, but also those of animals and biological systems in vitro.
The fourth edition also contains several new chapters on important
topics such as nanotoxicology, metals in prosthetics and dental
implants, gene-environment interaction, neurotoxicology, metals in
food, renal, cardiovascular, and diabetes effects of metal
exposures and more. Volume I covers "General Considerations" and
Volume II is devoted to "Specific Metals." A multidisciplinary
resource with contributions from internationally-recognized
experts, the fourth edition of the Handbook on the Toxicology of
Metals is a prominent and indispensable reference for
toxicologists, physicians, pharmacologists, engineers, and all
those involved in the toxicity of metals.
This volume offers the most comprehensive presentation available on
metal toxicology. It discusses not only metals but also the toxic
endpoints, such as neurotoxicity, renal toxicity, and cancer
induction. Chapters are written by experts in their respective
fields, focusing on carcinogenesis and human exposures and
highlighting the major aspects and issues of toxicity in general.
Molecular Biological Markers for Toxicology and Risk Assessment
provides an introduction to the exciting field of biomarkers and
their use in toxicology and risk assessment. In recent years, new
classes of molecular biomarkers capable of detecting early
manifestations of ongoing chemical-induced cell injury and cell
death have been developed as a result of advances in analytical
chemistry, molecular biology, and computational modeling. The
interplay between these emergent tools of science has resulted in
new insights into initial mechanisms of chemical-induced toxicity
and carcinogenicity. Molecular Biological Markers for Toxicology
and Risk Assessment guides the reader through a broad range of
molecular biological markers, including the "omic" biomarkers, and
provides an examination of the various elements in the evolution of
these modern tools. It then explores possible ways in which these
markers may be applied to advance the field of chemical risk
assessment. Since molecular biomarkers and related technologies are
inherently complex, the book concludes with a section on risk
communication in order that readers may appreciate both the
strengths and limitations of molecular biological marker approaches
to risk assessment practice.
Risk Assessment for Human Metal Exposures: Mode of Action and
Kinetic Approaches examines the current principles of risk
assessment in human metal exposures, with a focus on Mode of
Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations,
and computer models. Derived from the highly respected Handbook on
the Toxicology of Metals, Fourth Edition (2014), the book
summarizes principles and methods and provides examples of how MOA
-TKTD can be used. In addition, it presents tactics on how
information generated by such methods can be confirmed by
epidemiological data. Furthermore, it demonstrates how
epidemiological data can be confirmed and evaluated by the examined
models and considerations. This resource uniquely integrates
several important topics, such as risk assessment,
characterization, management and communication-the classic risk
assessment paradigm-with mode of action, TKTD, and epidemiology,
all topics related to human exposure. Written by pioneers in the
field, this book is an essential reference for researchers,
students and technicians in toxicology and risk assessment.
Electronic Waste: Toxicology and Public Health Issues discusses the
major public health concerns due to the presence of toxic chemicals
that are generated from improper recycling and disposal practices
of electronic waste (e-waste). This book highlights hazardous
inorganic chemicals found in e-waste, including arsenic, cadmium,
lead, mercury, gallium, iridium, and nanomaterials, also focusing
on health issues related to the presence of BPA, styrene, and other
plastic components and combustion products, while also identifying
populations at special risk. To provide readers with potential
solutions to this global problem, Dr. Fowler presents risk
assessment approaches using chemicals, mixtures, biomarkers,
susceptibility factors, and computational toxicology. He discusses
how to translate the information gathered through risk assessment
into safe and effective international policies. The final chapter
is devoted to future research directions. This is a timely and
useful resource for all those concerned with the health issues
surrounding e-waste management and proper disposal, including
toxicologists, public health and policy officials, environmental
scientists, and risk assessors.
"Computational Toxicology: Methods and Applications for Risk
Assessment" is an essential reference on the translation of
computational toxicology data into information that can be used for
more informed risk assessment decision-making. This book is
authored by leading international investigators who have real-world
experience in relating computational toxicology methods to risk
assessment. Key topics of interest include QSAR modeling, chemical
mixtures, applications to metabolomic and metabonomic data sets,
toxicogenomic analyses, applications to REACH informational
strategies and much more. The examples provided in this book are
based on cutting-edge technologies and set out to stimulate the
further development of this promising field to offer rapid, better
and more cost-effective answers to major public health
concerns.
Authored by leading international researchers engaged in
cutting-edge applications of computational methods for translating
complex toxicological data sets into useful risk assessment
informationIncorporates real-world examples of how computational
toxicological methods have been applied to advance the science of
risk assessment Provides the framework necessary for new
technologies and fosters common vocabularies and principles upon
which the effects of new chemical entities should be compared
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