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Methotrexate (Hardcover)
Bruce N. Cronstein, Joseph R. Bertino
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R2,559
Discovery Miles 25 590
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Ships in 12 - 17 working days
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This book provides multidisciplinary reviews of the mechanism of
action and uses of methotrexate in the treatment of cancer,
psoriasis, gynecologic and inflammatory diseases. The intended
audience is composed of clinicians involved in the care of patients
suffering from oncologic, gynecologic, rheumatic diseases as well
as scientists involved in research into the pathogenesis and
treatment of these diseases. This book is unique in that it
provides a single, state-of-the-art source for information
regarding the mechanism and use of methotrexate in many different
areas of medicine.
Although surprising, it seems fitting that a drug developed at the
dawn of the era of rational drug design and therapeutics,
methotrexate, should remain in common use for the therapy of so
many different kinds of illnesses. Moreover, methotrexate has
completely revolutionized the way in which medicine is practiced in
a number of speciality areas. First developed to treat
malignancies, methotrexate is now commonly used to treat
gynecological problems, inflammatory arthritis, skin disease and
probably other ailments as well. This work is designed to give a
broad overview of the history of methotrexate's development, its
prior use and its current therapeutic uses. As discussed in Chapter
I, aminopterin and methotrexate were designed to inhibit mammalian
folate metabolism but the concept of folic acid antag onism was
soon applied to the development of antibacterial and anti parasitic
agents. Trimethoprim and sulfa drugs were among the first
antibiotics developed and they also remain quite useful today for
the treat ment of a variety of infections."
After a century of research, several lines of evidence now indicate
that the ability of adenosine to directly control inflammatory
cells has a major impact on the functions of the inflammatory and
immune systems. Consequently, many promising therapeutic approaches
are beginning to emerge that focus on the modulation of adenosine,
including the development of compounds that interfere with the
breakdown of adenosine, as well as specific agonists and
antagonists of various adenosine subtypes. Some of these compounds
have already entered clinical trials. While information on the role
of adenosine is growing rapidly, until now it has remained
scattered in the literature. Edited by three pioneering researchers
in the field, Adenosine Receptors: Therapeutic Aspects for
Inflammatory and Immune Diseases presents the first single volume
compilation of reviews on how adenosine, acting on its cellular
receptors, regulates immune responses. The book is organized to
provide the reader with a general overview of adenosine receptors,
delving into molecular biology, cell biology, and pharmacology.
Separate chapters focus on the role of adenosine receptors in
regulating the function of the various cell types that are involved
in immune responses. Further chapters delineate the role of
purinergic signaling in the pathophysiology of a variety of disease
states associated with an overzealous or insufficient immune
response. These include autoimmune diseases, asthma,
atherosclerosis, ischemia-reperfusion injury, and cancer. Much of
the methodology and findings documented in this text may well lead
to new therapeutic modalities for pathologies such as ischemia and
reperfusion, heart disease, wound healing, tumors, pain, and a
variety of central nervous system diseases including Parkinson's,
Alzheimer's, and epilepsy, as well as mood and sleep disorders.
This resource provides background and direction for those
researchers entering the field of adenosine and inflammatory
disease, and provides a comprehensive reference for experienced
investigators.
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