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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Adenosine Receptors - Therapeutic Aspects for Inflammatory and Immune Diseases (Hardcover)
Loot Price: R7,937
Discovery Miles 79 370
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Adenosine Receptors - Therapeutic Aspects for Inflammatory and Immune Diseases (Hardcover)
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After a century of research, several lines of evidence now indicate
that the ability of adenosine to directly control inflammatory
cells has a major impact on the functions of the inflammatory and
immune systems. Consequently, many promising therapeutic approaches
are beginning to emerge that focus on the modulation of adenosine,
including the development of compounds that interfere with the
breakdown of adenosine, as well as specific agonists and
antagonists of various adenosine subtypes. Some of these compounds
have already entered clinical trials. While information on the role
of adenosine is growing rapidly, until now it has remained
scattered in the literature. Edited by three pioneering researchers
in the field, Adenosine Receptors: Therapeutic Aspects for
Inflammatory and Immune Diseases presents the first single volume
compilation of reviews on how adenosine, acting on its cellular
receptors, regulates immune responses. The book is organized to
provide the reader with a general overview of adenosine receptors,
delving into molecular biology, cell biology, and pharmacology.
Separate chapters focus on the role of adenosine receptors in
regulating the function of the various cell types that are involved
in immune responses. Further chapters delineate the role of
purinergic signaling in the pathophysiology of a variety of disease
states associated with an overzealous or insufficient immune
response. These include autoimmune diseases, asthma,
atherosclerosis, ischemia-reperfusion injury, and cancer. Much of
the methodology and findings documented in this text may well lead
to new therapeutic modalities for pathologies such as ischemia and
reperfusion, heart disease, wound healing, tumors, pain, and a
variety of central nervous system diseases including Parkinson's,
Alzheimer's, and epilepsy, as well as mood and sleep disorders.
This resource provides background and direction for those
researchers entering the field of adenosine and inflammatory
disease, and provides a comprehensive reference for experienced
investigators.
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