about the book... Assisting clinicians in the differential diagnosis of the wide range of disorders responsible for fever of unknown origin (FUO), this source stands as the only recent and comprehensive differential diagnosis of these conditions. This guide provides a clear overview of diagnostic approaches and offers expert recommendations that are invaluable to anyone caring for patients with prolonged undiagnosed fever. Written by clinicians for clinicians, this single authoritative source emphasizes the syndromic approach in the diagnosis of FUOs...discusses the etiology and distribution of disorders causing FUOs...and stresses the importance of a focused history, physical examination, and laboratory tests in the differential diagnosis of the FUO patient. about the editor... BURKE A. CUNHA is Chief, Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, and Professor of Medicine, State University of New York School of Medicine, Stony Brook. Dr. Cunha is the author or coauthor of more than 150 abstracts, 100 electronic publications, 1000 articles, and 150 book chapters. He has edited 20 books on various infectious disease topics and is Editor-in-Chief of the journals Infectious Disease Practice and Antibiotics for Clinicians. Dr. Cunha is a Fellow of the Infectious Diseases Society of America. Dr. Cunha is internationally recognized as a teacher-clinician and is the recipient of many teaching awards including the prestigious Aesculapius Award. Dr. Cunha is a Master the American College of Physicians awarded for lifetime achievement as a master clinician and teacher of infectious diseases. Dr. Cunha received the M.D. degree from Pennsylvania State UniversityCollege of Medicine, Hershey.

Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine 4E has been fully updated and revised. The clinical diagnostic approach to common infectious disease problems in the CCU is the underlying theme in the book. Emphasized throughout is the importance of formulating an accurate early presumptive clinical syndromic diagnosis which is the basis for selecting optimal initial antimicrobial therapy in the CCU. Without an accurate presumptive clinical diagnosis, effective therapy is unlikely at best. Based on the most probable clinical diagnosis, optimal antibiotic empiric therapy, based on antimicrobial stewardship principles, minimizes resistance and antibiotic complications in the CCU. This new edition features chapters that explain the tenets of differential diagnostic reasoning, differential diagnostic characteristics of fever patterns in the CCU. The proper interpretation of rapid diagnostic tests, in the appropriate clinical context, is included. The diagnostic importance of cardinal clinical findings, particularly when combined, in the appropriate clinical context is emphasized and remains the basis for clinical problem solving in the CCU. Uniquely, critical diagnostic physical findings in the CCU, including color atlas of diagnostic eye findings, are included as important diagnostic determinants in the CCU. Written by infectious disease clinicians for CCU consultants, Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine 4E remains a useful evidence based and experience tempered key clinical resource for infectious disease problems in the CCU. Key Features Essentials of the tenets of clinical diagnostic reasoning is explained as it relates to formulating a rapid and accurate clinical syndromic diagnosis in the CCU The diagnostic significance of fever patterns and their relationship to the pulse rate in the proper clinical context is explained in depth as related to the CCU setting Formulating an accurate early clinical syndromic diagnosis is presented as essential since it is the basis of effective empiric antibiotic therapy in the CCU How to combine key non-specific laboratory and imaging findings to increase diagnostic specificity and diagnostic probability in the CCU is presented Clinical perspective on the proper interpretation of the clinical significance of rapid diagnostic test results in the CCU is included A clinical approach to apparent "antibiotic failure" in the CCU is presented either due to actual antibiotic failure or seeming but unrelated non-antibiotic failure Section focuses on the practical aspects of antimicrobial stewardship particularly as related to optimizing dosing effectiveness while minimizing resistance and adverse effects in the CCU

It is a pleasure to contribute a brief foreword to this new, comprehensive 1980s saw an explosion of knowledge in pul text on the pneumonias. The is every reason to expect it to continue through monary science, and there the end of the century. As a result, it is becoming increasingly difficult to keep up with all the important advances, even in a restricted area of interest. For this reason, books such as the present one that collate the latest findings on an important clinical topic in a convenient, readable form provide a valuable service. This book is a salutary reminder that there is life beyond molecular and cell biology. Important though these disciplines are, some of us regret the lemming-like rush into these fashionable fields at the expense of more traditional pulmonary science. One result of this rush has been an increas ingly large number of residents and fellows who are unable to interpret the results of blood gas assays or who are completely at sea when presented with a patient who requires mechanical ventilation. The present perception that research funding is available only in molecular and cell biology has produced some unfortunate distortion of training programs. I pity the poor medical student in some of our most prestigious medical schools who is taught by a molecular biologist or neurophysiologist how the lung works. I wish the book well."

This comprehensive issue will present the state-of-the-art knowledge on Legionnaire's disease, coming from the country's top experts. Articles are devoted to: History of Legionnaire's Disease; Microbiology of Legionnaire's Disease; Epidemiology of Legionnaire's Disease; Clinical Features of Legionnaire's Disease; Radiologic Features of Legionnaire's Disease; Legionella Endocarditis; Legionnaire's Disease Mimics; Legionnaire's disease in Compromised Hosts; Legionnaire's Disease in HIV; Travel-Related Legionnaire's Disease; Legionnaire's Outbreaks; Laboratory Diagnosis of Legionnaire's Disease; and Antimicrobial therapy of Legionnaire's Disease.

Atypical pneumonia is pneumonia that is not caused by one of the traditional microorganisms, such as Streptococcus pneumoniae.? Once atypical pneumonia is diagnosed, it is important to identify the causative organism so treatment can be tailored to the pathogen.? This issue covers specific tests for atypical pathogens as well as taking an in depth look at specific microorganisms and diseases, including? mycoplasma, legionella, and SARS.