With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation protein-based "drugs" that are increasingly being used to treat human disease. Once a potential protein drug has been identified, the next rate-limiting step on the road to development is the production of sufficient authentic material for testing, charact- ization, clinical trials, and so on. If a protein drug does actually make it through this lengthy and costly process, methodology that allows the production of the protein on a scale large enough to meet demand must be implemented. Furthermore, large-scale production must not compromise the authenticity of the final product. It is also nec- sary to have robust methods for the purification, characterization, viral inactivation and continued testing of the authenticity of the final protein product and to be able to formulate it in a manner that retains both its biological activity and lends itself to easy administration. Therapeutic Proteins: Methods and Protocols covers all aspects of protein drug production downstream of the discovery stage. This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, f- mulation, and viral inactivation.

Blow by blow accounts of one young man's two Iditarod Trail Sled Dog Race runs. Takes the reader down the trail through the author's eyes, ears, legs, and hands. Primary focus tries to stay on the incredible Alaskan Husky sled dogs who pull the author across the wild breadth of Alaska. As handler for his uncle, four time Iditarod champion Martin Buser, Chapoton goes from rookie to Iditarod finisher, then does it again the following year. Dog lovers and adventure fans will enjoy this fast paced easy read.

Rarely do theological thinkers have the opportunity to present their own self-understanding of both their context and their methodology and the inter-relation of the two. This book gives leading theological minds from North America, Great Britain and Europe an opportunity to explore the shaping of their theological minds in regard to context and methodology. Asking 'why theology', each contributor explores their sense of call to the Christian faith, the purpose of their theological journey, and reflects on his or her context and theology. Cutting across denominational, gender, disciplinary, international and generational boundaries to explore shifts in theology and methodology, this book provides a diagnostic tool for examining where theology has come from and a compass to where theology is headed. Contributors include: James H Cone, Edward Farley, Colin E Gunton, Alister E McGrath, Wayne A Meeks, John Milbank, JA1/4rgen Moltmann, Gerald O'Collins, Rosemary Radford Ruether, Kathryn Tanner, Keith Ward and John Webster.

Theological thinkers are placed into contexts which inform their theological tasks but that context is usually limited to a European or North American centre, usually ignoring minorities and lesser mainstream theologies even in that context. This work focuses on the shift of Christian theological thinking from the North Atlantic to the Global South, even within the North Atlantic Church and Academy. It gives a Global perspective on theological work, method and context. Theologians from North America, Great Britain and Europe, Africa, Asia, Central and South America comment on how their specific context and methodology manifests, organizes and is prioritized in their thought so as to make Christian theology relevant to their community. By placing the Global South alongside the newly emerging presence of non-traditional Western forms such as Pentecostal, Aboriginal, and Hispanic theologies and theologians a clearer picture of how Christian theology is both enculturated and still familial is offered..

With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation protein-based "drugs" that are increasingly being used to treat human disease. Once a potential protein drug has been identified, the next rate-limiting step on the road to development is the production of sufficient authentic material for testing, charact- ization, clinical trials, and so on. If a protein drug does actually make it through this lengthy and costly process, methodology that allows the production of the protein on a scale large enough to meet demand must be implemented. Furthermore, large-scale production must not compromise the authenticity of the final product. It is also nec- sary to have robust methods for the purification, characterization, viral inactivation and continued testing of the authenticity of the final protein product and to be able to formulate it in a manner that retains both its biological activity and lends itself to easy administration. Therapeutic Proteins: Methods and Protocols covers all aspects of protein drug production downstream of the discovery stage. This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, f- mulation, and viral inactivation.

Silicon carbide (SiC) is a robust semiconductor material being actively developed for high-power and high-temperature applications, especially in the field of power electronics and sensors for harsh environments. This book, the fifth in a continuing series, focuses on SiC growth, defects, and devices. New developments in the growth of bulk SiC single-crystal materials, advances in the epitaxial growth of SiC, and progress in the characterization of materials properties and defects in SiC are featured. The volume also highlights the development of devices manufactured on this wide-bandgap semiconductor including: innovative device designs; characterization of device and materials properties; and improvements in wide-bandgap processing technology.

This book is the first comprehensive study of Mormon architecture. It centers on the doctrine of Zion which led to over 500 planned settlements in Missouri, Illinois, Utah, Idaho, Wyoming, Colorado, New Mexico, Arizona, California, Nevada, Canada, and Mexico. This doctrine also led to a hierarchy of building types from temples and tabernacles to meetinghouses and tithing offices. Their built environment stands as a monument to a unique utopian society that not only survived but continues to flourish where others have become historical or cultural curiosities. Hamilton's account, augmented by 135 original and historical photographs, provides a fascinating example of how religious teachings and practices are expressed in planned communities and architecture types.

This book is designed to help passengers better understand what the Lewis and Clark expedition experienced during those momentous years of 1804-1806, but also to be able to see through vintage photographs and other images what the members of the Corps of Discovery saw before the rivers were changed forever by hydroelectric dams. It affords an opportunity to travel "in the wake of Lewis and Clark." Leaving St. Louis on May 14, 1804, with thirty-four soldiers, hired voyagers, and Clark's slave, York, they traveled through the unexplored territory and beyond it, to the Pacific Ocean. Their exploits come alive today as cruise ships travel their route up and down the Snake and Columbia Rivers.

This book, which comes with a Money Back Guarantee, was written from the author's own spiritual journey. So many of us - both church goers and non-church goers - have struggled with how to get our prayers answered. Why do we experience such pain and suffering in spite of our prayer life? "For many of us, the experience of spending time with God is like spending time with an old spouse or lover. The flame of passion is not there, but the sense of responsibility is. We meet our obligatory Sunday responsibilities and daily prayer rituals - not with passion and purpose - but with dread and impotence. It is no wonder, then, that we are so easily distracted and seldom reach that secret place where peace awaits us." In this book we will explore the appropriate prayer attitude, posture, language, and expectation. When we have the proper understanding going in, then we get the proper result coming out. It's really that simple.

Some names are best forgotten ... The Nameless Dwarf follows the trail of the last of his race to the mountains bordering Qlippoth, a wasteland born from the dreams of a craven god. But the survival of the dwarves depends on his willingness to confront the bloody deeds of his past, and the ruler of the brigand town of Malfen, who guards the pass into Qlippoth-an aberration known as the Ant-Man. The Chronicles of the Nameless Dwarf are a blend of Sword and Sorcery and contemporary fantasy, combining strange worlds, dark magic, heroic action and an astonishing depth of world building. The Ant-Man of Malfen reintroduces the Nameless Dwarf from the acclaimed SHADER series by D.P. Prior. Nameless is a manic-depressive pariah whose past is littered with atrocities. Possessing an almost elemental ferocity and a gift for violence, Nameless alternates between bouts of crippling depression and boisterous episodes of elation, which are usually brought on by the prospect of a good fight; and he has an eye for the women - particularly those under four feet tall. This story also introduces Silas Thrall, a student of the mantic arts with a dark secret that consumes more each day; and Nils Fargin, son of the most feared guildmaster in New Jerusalem.

Blow by blow accounts of one young man's two Iditarod Trail Sled Dog Race runs. Takes the reader down the trail through the author's eyes, ears, legs, and hands. Primary focus tries to stay on the incredible Alaskan Husky sled dogs who pull the author across the wild breadth of Alaska. As handler for his uncle, four time Iditarod champion Martin Buser, Chapoton goes from rookie to Iditarod finisher, then does it again the following year. Dog lovers and adventure fans will enjoy this fast paced easy read.