Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. The book also covers topics that are more advanced in development to emerging scientific discoveries. In particular, this monograph includesconcepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases.Thisbook renews established concepts in the field, and at the same time leads to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.

Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. The book also covers topics that are more advanced in development to emerging scientific discoveries. In particular, this monograph includes concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. This book renews established concepts in the field, and at the same time leads to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.

In the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry. In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field.

The nine papers of this Supplement on these significant issues and important ideas are closely accentuated and critically discussed by well-established specialists, philosophers and historians, from various relevant disciplines of study.

Since the end of the nineteenth century, Chinese philosophy has experienced an intensely self-conscious creative transformation. Contemporary Chinese philosophers developed sophisticated positions in many central areas of philosophy and set out to reinterpret the complex inheritance of ancient Chinese philosophy. "

Contemporary Chinese Philosophy" features leading scholars describing and critically assessing the works of sixteen major twentieth-century Chinese philosophers. The book explores these philosophers' attempts to revive and modernize the Confucian, Daoist, Mohist, Legalist, Logicist, Neo-Confucian, and Buddhist schools as well as their critiques of Western thinkers from Plato to Wittgenstein. It demonstrates that the values and achievements of Chinese philosophers offer a gateway to understanding the development of Chinese views of humanity and reality.

This volume enables students and general readers to understand the rich and challenging diversity of issues and positions explored in contemporary Chinese philosophy.