In the past thirty years, significant advances have been made in
the field of reproductive biology in unlocking the molecular and
biochemical events that regulate spermatogenesis in the mammalian
testis. It was possible because of the unprecedented breakthroughs
in molecular biology, cell biology, immunology, and biochemistry.
In this book entitled, Molecular Mechanisms in Spermatogenesis, a
collection of chapters has been included written by colleagues on
the latest development in the field using genomic and proteomic
approaches to study spermatogenesis, as well as different
mechanisms and/or molecules including environmental toxicants and
transcription factors that regulate and/or affect spermatogenesis.
The book begins with a chapter that provides the basic concept of
cellular regulation of spermatogenesis. A few chapters are also
dedicated to some of the latest findings on the Sertoli cell
cytoskeleton and other molecules (e.g., proteases, adhesion
proteins) that regulate spermatogenesis. These chapters contain
thought-provoking discussions and concepts which shall be welcomed
by investigators in the field. It is obvious that many of these
concepts will be updated and some may be amended in the years to
come. However, they will serve as a guide and the basis for
investigation by scientists in the field.
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