Mitochondria and Longevity, Volume 340, the latest release in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics with this release focusing on topics such as Mitochondria metabolism and aging, Mitohormesis, Mitochondrial dynamics in the aging stem cell compartment, Mitochondrial proteostasis and aging, Mitochondrial DNA mutations and aging, Mitochondrial sirtuins, NAD+, NADH and aging, Mitophagy and aging, Mitochondria, calcium transport and aging.

Advances in communication technologies have created an overabundance of available information and knowledge to people in contemporary society. Consequently, it has become pivotal to develop new approaches for information processing and understanding. Information and Communication Overload in the Digital Age is a comprehensive reference source for the latest scholarly material on the increased amount of information created by evolving technologies, examining creative methods for improved control of information overload. Focusing on theoretical and experimental topics, such as media consumption, media literacy, and business applications, this book is ideally designed for researchers, practitioners, academics, graduate students, and professionals seeking emerging perspectives on information and communication management.

Carlos Lopez Dzur ha reunido sesenta de sus relatos en una coleccion que constituye una novela El pueblo en sombras y un personaje colectivo: el Pueblo de San Sebastian del Pepino, municipio puertorriqueno fundado en 1752. Del espectro de habitantes y, entre tan distintas personalidades y clases sociales, nos lleva a conocer a una que se aplauden con empatia y otras que fueron temidas. Revela momentos epocales de antes de 1898 y describe, el caracter particular de los tipos humanos segun se transforma la idiosincracia colectiva. Estos episodios, sacan de las sombras, en que cobijaron una especie de aislamiento que asfixiaba, de ambiente incestuoso, de insularismo, de genealogias y abolengos venidos a menos, de maldiciones que se cargaban de generacion en generacion como una telenovela, que le daba cierto cariz de Macondo al pueblo Dr. Arnaldo Cruz-Malave, profesor de Literatura Comparada y director asociado del Latin American and Latino Studies Institute, de Fordham University, New York]. La novela avanza para recrear a personajes de ayer y otros mas comtemporaneos que se fueron a los EE.UU., a los barrios newyorkinos y de Chicago y expone como fue su readpatacion o desadaptacion a su regreso. Entre los personajes del libro: Mantillita, la Beata, Don Perico, Juanito Rosa, Luisa Bottari, Chilin el Malo, Cucan Oronoz, Nano Ortiz, Cheo el Oso, Lolo Puya, Nico Chavito, Yayo el Turco, Sopanda y muchos otros."

Bio-inspired Algorithms for Engineering builds a bridge between the proposed bio-inspired algorithms developed in the past few decades and their applications in real-life problems, not only in an academic context, but also in the real world. The book proposes novel algorithms to solve real-life, complex problems, combining well-known bio-inspired algorithms with new concepts, including both rigorous analyses and unique applications. It covers both theoretical and practical methodologies, allowing readers to learn more about the implementation of bio-inspired algorithms. This book is a useful resource for both academic and industrial engineers working on artificial intelligence, robotics, machine learning, vision, classification, pattern recognition, identification and control.

This volume includes contributions presented at the Fifth IFToMM Symposium on the History of Machines and Mechanisms, held at Universidad Autonoma de Queretaro, Santiago de Queretaro, QRO, Mexico, in June 2016. It contains work on theories and facts concerning mechanisms and machines from antiquity to current times as viewed in the present day. Topics include modern reviews of past works; people, history, and their works; direct memories of the recent past; historic development theories; the history of the design of machines and mechanisms; developments of mechanical design and automation; the historic development of teaching; the history of schools of engineering and the education of engineers.

Based on an extensive national survey of workers and four separate industry-specific surveys, Generations and Work will examine and provide answers to the most common issues and problems of multi generational work by assessing differences and commonalities between and among generations.

Neural Networks Modelling and Control: Applications for Unknown Nonlinear Delayed Systems in Discrete Time focuses on modeling and control of discrete-time unknown nonlinear delayed systems under uncertainties based on Artificial Neural Networks. First, a Recurrent High Order Neural Network (RHONN) is used to identify discrete-time unknown nonlinear delayed systems under uncertainties, then a RHONN is used to design neural observers for the same class of systems. Therefore, both neural models are used to synthesize controllers for trajectory tracking based on two methodologies: sliding mode control and Inverse Optimal Neural Control. As well as considering the different neural control models and complications that are associated with them, this book also analyzes potential applications, prototypes and future trends.

Featuring chapters from an international range of leading and emerging scholars, this Handbook provides a collection of cutting-edge, interdisciplinary research that sheds new light on contemporary futures studies. Engaging with key defining questions of the early twenty-first century such as climate change, big data, AI, the future of economics, education, mental health, cities and more, the Handbook provides a review and synthesis of futures scholarship, highlighting the role that societies can and should play in their making. While the various chapters demonstrate how futures emerge and take shape in particular places at particular times, the distinctive insight provided by the volume overall is that futures thinking today must be social and contextual. By presenting a range of futures work from contexts around the globe, the Handbook contextualizes techniques - forecasting, backcasting, scenario planning, collaboration and co-production- to ask how different dimensions of the social are created and circulated in the process. Through its thirty chapters, the volume explores and interrogates narratives, anticipations, enactments, ecologies, collaborations, prospections and so on to highlight which versions of the social are legitimized and which are encouraged and foreclosed. This Handbook opens an important conversation about the centrality of the social in futures thinking. By bringing arts, humanities and social sciences scholars and practitioners into conversation with biologists, environmental, climate and computer scientists, this volume seeks to encourage new pathways across, between and within multiple disciplines to interrogate the futures we need and want. The social must be our starting point if we are to steer our planet in a direction that supports good lives for the many, everywhere.

This book gathers high-quality papers presented at International Conference on Science, Technology and Innovation for Society (CITIS 2021), held in Guayaquil, Ecuador, on May 26-28, 2021. This book will present the recent research trends in the fields of software engineering, big data analysis, cloud computing, data engineering, data management and data mining, machine learning, deep learning, artificial intelligence, smart systems, robotics and automation, mechatronic design, and industrial processes design.

The main objective of this book is to identify the key sources of growth which have played a significant role in Africa's recent robust growth as well as its efforts towards economic transformation. The book assesses to what extent the existing macroeconomic frameworks among African countries have been streamlined to the countries' development priorities in order to achieve long-term growth and economic transformation. Taking into account the diversity of African countries, the authors establish the economic linkages between relevant macroeconomic policy variables and the key sources of growth and development among the selected African economies, based on both theoretical and empirical underpinnings. Following this, an outline of a macroeconomic framework for Africa's long-term growth and economic transformation is suggested.

Cities, Railways, Modernities chronicles the transformation that London and Paris experienced during the nineteenth century through the lens of the London Underground and the Paris Metro. By highlighting the multiple ways in which the future of the two cities was imagined and the role that railways played in that process, it challenges and refines two of the most dominant myths of urban modernity: A planned Paris and an unplanned London. The book recovers a significant body of work around the ideas, the plans, the context and the building of metropolitan railways in the two cities to provide new insights into the relationship of transport technologies and urban change during the nineteenth century.

Cities, Railways, Modernities chronicles the transformation that London and Paris experienced during the nineteenth century through the lens of the London Underground and the Paris Metro. By highlighting the multiple ways in which the future of the two cities was imagined and the role that railways played in that process, it challenges and refines two of the most dominant myths of urban modernity: A planned Paris and an unplanned London. The book recovers a significant body of work around the ideas, the plans, the context and the building of metropolitan railways in the two cities to provide new insights into the relationship of transport technologies and urban change during the nineteenth century.

Un nino judio (Karl ben Abram), nacido en La Habana, examina el distanciamiento de su padre y el por que su madre (Sara) decide sacarlo de Cuba, en momentos en que la Revolucion en ciernes divide a la familia que apenas comienza a conocer. Segun crece va recaudando un material informativo y memorante que incluye genealogias de sus ancestros, mismo en el que se mezclan askenazis con sefarditas, revolucionarios con sionistas y agentes mercenarios. Al final, la comprension reconciliadora que el nino y adolescente buscara con su padre fracasa al descubrirlo como un agente de la CIA. El distanciamiento es total porque, pese a su actividad exitosa, como medico y espia en favor de los EE., UU., el Dr. Abram, infiel, mujeriego, es emocionalmente infeliz, torturado por culpas y prejuicios, que se proyectan contra su esposa e hijo, su hermano y mas antigua parentela. Lopez Dzur contrapone la vision sionista-territorialista, pro-dominialista del agente anticastrista, y la que sustenta Sara, que es mucho mas espiritual, pero equilibrada por una conciencia social desarrollada y de izquierda. Por razones fuera de su control, ella decide salir de Cuba, con su hijo, sin pretender complicidad con actividades contrarrevolucionarias.

The book offers an insight on artificial neural networks for giving a robot a high level of autonomous tasks, such as navigation, cost mapping, object recognition, intelligent control of ground and aerial robots, and clustering, with real-time implementations. The reader will learn various methodologies that can be used to solve each stage on autonomous navigation for robots, from object recognition, clustering of obstacles, cost mapping of environments, path planning, and vision to low level control. These methodologies include real-life scenarios to implement a wide range of artificial neural network architectures. Includes real-time examples for various robotic platforms. Discusses real-time implementation for land and aerial robots. Presents solutions for problems encountered in autonomous navigation. Explores the mathematical preliminaries needed to understand the proposed methodologies. Integrates computing, communications, control, sensing, planning, and other techniques by means of artificial neural networks for robotics.

This book addresses whether Guinea-Bissau is a nation or a nation in formation; what the political and ideological foundations of the national liberation movement are; and how one should characterize the historical transition from a national liberation movement to a state.

The book offers an insight on artificial neural networks for giving a robot a high level of autonomous tasks, such as navigation, cost mapping, object recognition, intelligent control of ground and aerial robots, and clustering, with real-time implementations. The reader will learn various methodologies that can be used to solve each stage on autonomous navigation for robots, from object recognition, clustering of obstacles, cost mapping of environments, path planning, and vision to low level control. These methodologies include real-life scenarios to implement a wide range of artificial neural network architectures. Includes real-time examples for various robotic platforms. Discusses real-time implementation for land and aerial robots. Presents solutions for problems encountered in autonomous navigation. Explores the mathematical preliminaries needed to understand the proposed methodologies. Integrates computing, communications, control, sensing, planning, and other techniques by means of artificial neural networks for robotics.

'The United Nations system was a pioneer in the field of technical cooperation, and capacity development is its central mandate. UNDP has long played an important leadership role in both, as a source of technical cooperation funds and advisory services and as the home of innovative intellectual research and analysis on how to make them more efficient and effective. This book presents] a vision that builds on new possibilities for knowledge-sharing, for which the revolution in information and communications technologies offers ample opportunities... a vision that is firmly founded on genuine ownership by the ultimate beneficiaries of development efforts: the government and citizens of developing countries' From the Foreword by MARK MALLOCH BROWN, Administrator, UNDP Capacity for Development brings together innovative and well-supported studies of technical cooperation along with its potential to build sustainable capacities in developing countries, by enhancing the knowledge, skills and productive aptitudes of their populations. A team of eminent development professionals and economists examine the achievements of technical cooperation and offer recommendations for reform in the context of globalization, democratisation, the information revolution and the growth of capacities in the South. They analyse the issues from three perspectives: ownership, capacity enablers and knowledge. The team show how the complex processes involved can be restructured to produce local involvement and empowerment, set out a normative framework for the input from society, and describe a new paradigm of knowledge for capacity building in the network age. This book will be essential reading for all development professionals and policy-makers, as well as providing an invaluable research and teaching resource.

This book addresses whether Guinea-Bissau is a nation or a nation in formation; what the political and ideological foundations of the national liberation movement are; and how one should characterize the historical transition from a national liberation movement to a state.

Debates on African development continue to downplay the achievement of the continent: economic achievements are diminished and the perception of a conflict prone continent continues. Many of the policy prescriptions externally imposed on African countries have done little to transform the continent largely because they have been conceived and applied without context. Using literature from diverse origins, this book expands our knowledge about Africa and makes practical suggestions as to how successful development in a complex, yet dynamic continent can be achieved. Widening the policy dialogue and providing alternative thinking on the key elements and full extent of opportunities and challenges towards achieving the socio-economic transformation of Africa, the book moves the debate from the rhetoric to reality. As a considered reflection on the 'Africa's transformation' narrative, it outlines the practical pathways necessary for Africa's sustainable development, providing policy makers and researchers with tested solutions. It will be of interest to all scholars, students and policy professionals working in African development, public policy, international political economy, economic policy and politics.

This book reviews Cabral s intellectual contribution to current debates on race, identity, nation building, democracy, leadership and ethics. The key leader of the national liberation movements of former Portuguese African colonies is considered to be one of their foremost intellectuals the continent has produced. This rare combination of freedom fighter, operational campaigner and astute political scientist justifies the academic interest in his contribution.

Africa's Contemporary Challenges reviews the impact of Amilcar Cabral s thinking, and its relationship with contemporary debates about race, identity, nation building, democracy, leadership or ethics. The complexity of Cabral s vision and hopes for Africa continues to incite curiosity and interest. Cabral's tragic assassination in 1973 has removed the possibility of analysing his impact on post-independent Lusophone Africa, but his thoughts continue to be the most important reference.

This book was published as a special issue of African Identities.

The third and final in a series, this text bridges the conceptual foundations of capacity development and the difficulties and practical realities in the field. It demystifies the process of capacity development to make it more "user-friendly".;The book has two parts. The first shows how long-standing development dilemmas can be turned into opportunities for capacity development and societal transformation. It proposes a set of principles to guide the search for context-specific approaches as the norm, and based on these default principles the authors explore relevant issues in comprehensible stages through a capacity lens.;The second part is a compilation of experiences and lessons from around the world, to showcase promising initiatives and innovative solutions. It forms a casebook of insights and good (rather than best) practices on how development stakeholders can turn development dilemmas into opportunities tailored to the needs of their societies.

It is now over ten years since we edited the first edition of HLA-B27 in the Development of Spondyloarthropathies (SpA). It is obvious that over this period an enormous amount of information concerning SpA and HLA-B27 has accumulated, and this has been reflected in the knowledge of molecular mechanism of the spondyloarthropathies. Discussion for such a book took initial form at the outstanding 4th Gent Symposium on SpA in October 2006, but was not formally commissioned by Landes Bioscience until early 2007. Molecular Mechanisms of Spondyloarthropathies aims to synthesize this growing knowledge and present all the current studies concerning the basic research of SpA. Over the last decade, enormous progress has been made in the understanding of the molecular and cellular processes that lead to disease pathology. Recognition of the pathways involved in the pathogenic mechanisms of disease and the potential to target specific immune effector functions have opened the door to a wide range of innovative treatment opportunities for the SpA. Thus, we believe that the understanding of the specific molecular mechanisms involved would help to design highly specific drugs in the future. The contributors are among the best in their field and reflect the state of the art of research and current opinion of rheumatologists and immunologists.

Artificial Neural Networks for Engineering Applications presents current trends for the solution of complex engineering problems that cannot be solved through conventional methods. The proposed methodologies can be applied to modeling, pattern recognition, classification, forecasting, estimation, and more. Readers will find different methodologies to solve various problems, including complex nonlinear systems, cellular computational networks, waste water treatment, attack detection on cyber-physical systems, control of UAVs, biomechanical and biomedical systems, time series forecasting, biofuels, and more. Besides the real-time implementations, the book contains all the theory required to use the proposed methodologies for different applications.

'You damn sadist/said mr cummings 'you try to make people think. ' -Ezra Pound (Canto 89) What makes herpesviruses unique? It is certainly not the size of their genomes or the individual features of their reproductive cycle, although in toto striking features that are exclusive to the herpesviruses abound. Unquestionably, the pre-eminent feature is the relationship of herpes viruses with their natural hosts. As described in preceding volumes, all herpesviruses seem to be able to colonize and to remain in a latent, nonproductive form for life of their hosts. Once established in the host, the relationship is best described as that of an armed truce. What happens when this truce breaks down or when the host encounters the virus for the first time is the subject of this volume. We have focused primarily on the five human herpesviruses herpes simplex virus 1 (HSV-l), herpes simplex virus 2 (HSV-2), cytomegalovirus (CMV), varicella zoster virus (VZV) and Epstein-Barr virus (EBV)] because much more is known about them than about any other herpesviruses, and because it is of interest to compare both the diversity of manifestations of infections with human herpesviruses and the spectrum of human responses to these viruses. This volume summarizes the current knowledge of the pathogenesis and immunobiology of herpesvirus infections in man and describes new and developing approaches to prophylaxis and treatment. It contains con tributions from distinguished research scientists presently engaged at the forefront of these scientific investigations."