Madam Hortensia followed her routine to a tee, until one day everything went wrong… what a disaster! A wonderful story, full of humor, about the importance of tackling new challenges. Do you dare to change?Madam Hortensia lives life in a straight line, never straying a step out of her daily routine.  Was she finicky? Not quite, she just liked everything to be perfectly to her liking. Her alarm clock rang every day at 07:18 sharp. Not one minute before, or one minute after. Then her planned routine would begin in extreme detail, and nothing could possibly go wrong. But one morning, her alarm does not go off on time and her life spins into a whirlwind. Suddenly, she finds herself doing entirely new things she has never tried before. With wit and charm, this delightful tale shares what happens when we learn to embrace change and open our minds to possibility. Doña Hortensia seguía su rutina al pie de la letra hasta que un día todo se torció… ¡menudo desastre! Un cuento maravilloso, lleno de humor, sobre la importancia de abordar nuevos retos. ¿Te atreves a cambiar?Para Doña Hortensia cada día era igual y lo vivía sin salirse ni un milímetro de su rutina habitual. ¿Era perfeccionista? No exactamente; simplemente le gustaban que todo estuviera perfectamente a su gusto. Cada mañana se levantaba a las 07:18 en punto; ni un minuto antes, ni un minuto después. Entonces empezaba su rutina planificada en extremo detalle, y nada podía fallar. Hasta que, una mañana, la alarma del despertador no sonó a la misma hora y… ¡Todo lo que ocurrió después fue como un torbellino que le despeinó las ideas! De repente, se encontró disfrutando de situaciones nuevas que antes ni siquiera hubiese podido imaginar. Una divertida historia que nos muestra, con ingenio y sentido del humor, lo que ocurre cuando nos atrevemos a abandonar nuestra zona de confort y abrimos la mente a nuevas posibilidades.

Gold Medal Winner at the 2017 Moonbeam Children's Book Awards Everybody in the farmyard loves Daisy the donkey, but as she gets older, she becomes weaker, less agile, and can't hear so well. Then, one day, a beautiful pony full of life and energy arrives at the farm and captures everyone's attention. In this charming tale, readers will discover the value of the experience and wisdom we learn with the passing of the years. Guided Reading Level: M, Lexile Level: 650L

A lively and popular introductory textbook teaching Spanish to absolute beginners working in a classroom setting. A diverse range of dialogues, video clips, and reading passages deliver new material which is carefully practised in a wide variety of imaginative exercises, both individually and in pair- and groupwork, and backed up by structured grammatical underpinning and exercises. Foundations Languages courses are tailor-made for undergraduates and other students on Institution-wide Languages Programmes (IWLPs), languages options and electives, ab initio and minor routes in languages, and open learning programmes at universities and in Adult Education. Foundations Spanish 1 assumes no previous knowledge. New to this Edition: - Fully revised and updated following extensive lecturer feedback - First time in full colour! - New photos and illustrations - New integrated video clips - Code for interactive ebook inside to allow easy access to video, audio and interactive exercises and great searchability - Extra online grammar and video exercises - New cultural notes - Voiced vocabulary lists Accompanying online resources for this title can be found at bloomsburyonlineresources.com/macmillan-foundations. These resources are designed to support teaching and learning when using this textbook and are available at no extra cost. Included are: accompanying audio and video, a substantial self-study section with practice material for homework and revision, and for extension purposes.

Anastasia, formerly a princess thanks to the fairy Brunilda's magic wand, is now an everyday cockroach with a big heart, determined to do good. She dreams of becoming a famous, important figure like her distant relatives, the Egyptian scarab beetles who are treated like royalty. After some exciting adventures in her new incarnation--including saving the lives of an entire human family--Anastasia realizes it's not so bad being an ordinary cockroach after all. Will Brunilda reward Anastasia for her generous deeds? This humorous tale of self-acceptance and unity is sure to have children seeing cockroaches in a new light.
"Anastasia, anteriormente una princesa gracias a la varita magica del hada Brunilda, ahora es una cucaracha cualquiera con un corazon grande, empenada en hacer el bien. Suena con ser famosa e importante como sus parientes lejanos, los escarabajos egipcios que son tratados a cuerpo de rey. Despues de algunas aventuras emocionantes en su nueva encarnacion--incluyendo cuando le salva la vida a una familia de seres humanos--Anastasia se da cuenta de que ser una cucaracha comun y corriente no esta tan mal despues de todo. Recompensara Brunilda a Anastasia por sus generosas acciones? Esta historia humoristica que trata sobre la aceptacion de uno mismo y la solidaridad hara que los ninos vean a las cucarachas con otros ojos."

For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.