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Drug Discovery for Leishmaniasis (Hardcover)
Loot Price: R5,216
Discovery Miles 52 160
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Drug Discovery for Leishmaniasis (Hardcover)
Series: Drug Discovery, Volume 60
Expected to ship within 12 - 17 working days
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For human health, leishmaniasis is among the most important
protozoan diseases, superseded only by malaria. Globally, 10 to 12
million people are infected with 1.5 million new cases every year.
The development of cheaper new drugs is urgently needed for this
neglected disease that is developing resistance to current
treatments. Chemotherapy remains the only treatment option for the
bulk of patients. However, this is largely unaffordable for most.
In the past three years numerous advances in drug discovery have
been made for treating this disease by exploiting diverging
metabolic pathways between the Leishmania enzymes and their hosts,
using nanotechnology to target the immune cell phagolysosomes where
Leishmania resides. Drug Discovery for Leishmaniasis aims to
provide a perspective of the current treatments and their
challenges, blended with the emerging strategies and methodologies
that will drive new target appraisals and drug developments, as
well as addressing the molecular basis of resistance in Leishmania.
Recent studies have shown that leishmaniasis affects some of the
poorest people in the world, with 95% of fatal cases occurring in
only 6 countries. With the WHO goal of eliminating this public
health problem in the South-east Asia Region by 2020, this book
will be important for anyone who is interested in neglected
tropical diseases.
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