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The past few years have witnessed an astonishing international
effort that established the role of some 20 new molecules in
apoptosis and added activation or suppression of apoptosis to the
accepted biological functions of a great many others already
familiar in cancer biology. Some of these molecules are receptors,
transducing cytokine-mediated signals; others appear to intensify
or diminish the risk that a compro mised cell will fire its
apoptosis effector mechanism. All are of interest as potential
targets for tumor therapy, and some may prove to be control points
influenced in the pathogenesis of cancer and other diseases as
diverse as viral infection, neurodegenerative disorders, and
stroke. Sometimes, in the midst of these developments, a kind of
euphoria ap pears to have gripped the research community, with the
expectation that apoptosis will afford explanations to many
unsolved questions in cellu lar regulation. This book, in a series
of thoughtful and provocative ar ticles--some from established
leaders in the field, and others from younger scientists--seeks to
redress the balance."
This collection of thoughtful and provocative articles focused on
the key issues in apoptosis, ranges from the role of apoptosis in
defining the response of authentic tumor populations to
chemotherapeutic agents to the mechanisms coupling DNA damage to
the activation pathway of apoptosis. It reviews the profusion of
new signaling, modulating, and effector molecules now implicated in
apoptosis and whether other routes to "programmed" cell death may
exist. Also addressed are the nature of the molecules that will
either constitute targets for future drugs or influence the
efficacy of current therapies, as well as mechanistic questions on
the control of apoptosis. By focusing on essential questions and
critically summarizing the overwhelming tide of recent research
results, Apoptosis and Cancer Chemotherapy illuminates not only the
potential targets for tumor therapy, but beyond that, potential
control points for cancer and such diverse diseases as viral
infection, neurodegenerative disorders, and stroke. This collection
of cutting-edge reviews by established leaders in the field
critically summarizes the recent discoveries concerning apoptosis,
cell suicide. The book looks forward to the time when such cell
death can be controlled to treat cancer and a host of other
diseases as diverse as viral infection, neurodegenerative
disorders, and stroke.
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