The past few years have witnessed an astonishing international
effort that established the role of some 20 new molecules in
apoptosis and added activation or suppression of apoptosis to the
accepted biological functions of a great many others already
familiar in cancer biology. Some of these molecules are receptors,
transducing cytokine-mediated signals; others appear to intensify
or diminish the risk that a compro mised cell will fire its
apoptosis effector mechanism. All are of interest as potential
targets for tumor therapy, and some may prove to be control points
influenced in the pathogenesis of cancer and other diseases as
diverse as viral infection, neurodegenerative disorders, and
stroke. Sometimes, in the midst of these developments, a kind of
euphoria ap pears to have gripped the research community, with the
expectation that apoptosis will afford explanations to many
unsolved questions in cellu lar regulation. This book, in a series
of thoughtful and provocative ar ticles--some from established
leaders in the field, and others from younger scientists--seeks to
redress the balance."
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