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The finding by Emil Fischer that glucose and fructose on treatment
with phenylhydrazine gave the identical osazone led him to the
elucidation of stereochemistry of carbohydrates. Since then,
progress in the field of carbohydrates has been amazing with the
unraveling their basic structure, biosynthesis, immunology,
functions, and clinical uses, for pure carbohydrates and for
protein-linked carbohydrates (glycoproteins and proteoglycans).
The chemistry, biochemistry and pharmacology of heparin and heparan
sulfate have been and continue to be a major scientific undertaking
- heparin and its derivative remain important drugs in clinical
practice. Chemistry and Biology of Heparin and Heparan Sulfate
provides readers with an insight into the chemistry, biology and
clinical applications of heparin and heparan sulfate and examines
their function in various physiological and pathological
conditions. Providing a wealth of useful information, no other tome
covers the diversity of topics in the field. Students, doctors,
chemists, biochemists, and research scientists will find this book
an invaluable source for updating their current knowledge of
developments in this area.
It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow.
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