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The erythrocyte is perhaps the world's single best known cell, an opinion affirmed by its inseparable linkage with the French expression "Le sang c'est la vie" (i.e., Blood is life). The red cell made its debut in a few invertebrates and thereupon conducted a conceptual phylogenetic odyssey through the Classes of poikilothermic vertebrates, onward to the first homeotherms the avians, and thereafter to the mammals including man. The erythrocyte presents morphologic, cytochemical and quantitative adaptations as it progresses through its evolutionary continuum. The specific objective of this text is to explore in depth the cytology of the erythrocyte in birds. It is intended to derive an understanding of the red cell's diverse aspects as presented among Orders, Families and Genera of avians. Illustrative of the subjects that are explored are the light microscopy and ulrastructure of the maturational sequence of the erythrocyte from proerythroblast to the mature cell, the quantitative representation of the erythroid progenitors in hemopoietic bone marrow, and the relationship of erythropoiesis with the vascular sinuses in the bone marrow. Sections are devoted to the quail-chick chimera and the insight it offers, erythroleukemia, embryologic considerations, primitive and definitive generation erythrocytes, rbc life span, the impact of sporozoan parasitization upon the erythrocellular profile and the morphology associated with pathologic agents and conditions. A major segment of the monograph is a taxonomically organized Table of Erythrogramic Data (primary source-cited, and when derived, indicators of significant differences between sexes, physiologic and experimental conditions).
Erythrocytes of the Rhesus and Cynomolgus Monkeys addresses the morphologic, quantitative, and generative aspects of the erythrocytes of the rhesus monkey Macaca mulatta and the cynomolgus monkey Macaca fascicularis (long-tailed macaque, crab-eating monkey). These two species are the most commonly selected nonhuman primates for basic science and clinical medical investigations. The hemopoietic cells of man and the rhesus monkey display an intimate homogeneity. Their functional activities are close and at times identical. The cynomolgus monkey was enlisted in biomedical studies at a time when rhesus monkeys were not available in sufficient quantities. It has gained increased use in the Far East and in the Western world. It is, for example, employed in the current development of a vaccine against the deadly Ebola virus. The authors of the book discuss the erythropoietic profiles of normal and abnormal macaques of both sexes and of all age groups as investigated with contemporary electronic methodologies. They cover the role of stress as it is perceived by the monkey and how it impacts erythrocellular values, and how to train the monkey to be a cooperative, unperturbed subject for hematologic study. Additional topics include the role of medication in deriving normal physiologic erythrocellular data, the development of the precursors of the erythrocyte (normoblasts), the morphologic analysis of the megaloblastic series of abnormal erythroid cells, the analysis of erythropoiesis in bone marrow, the relationship of the simian immunodeficiency virus and erythropoiesis, erythrocyte life span, and parasitic invasion of the red cell.
Erythrocytes of the Rhesus and Cynomolgus Monkeys addresses the morphologic, quantitative, and generative aspects of the erythrocytes of the rhesus monkey Macaca mulatta and the cynomolgus monkey Macaca fascicularis (long-tailed macaque, crab-eating monkey). These two species are the most commonly selected nonhuman primates for basic science and clinical medical investigations. The hemopoietic cells of man and the rhesus monkey display an intimate homogeneity. Their functional activities are close and at times identical. The cynomolgus monkey was enlisted in biomedical studies at a time when rhesus monkeys were not available in sufficient quantities. It has gained increased use in the Far East and in the Western world. It is, for example, employed in the current development of a vaccine against the deadly Ebola virus. The authors of the book discuss the erythropoietic profiles of normal and abnormal macaques of both sexes and of all age groups as investigated with contemporary electronic methodologies. They cover the role of stress as it is perceived by the monkey and how it impacts erythrocellular values, and how to train the monkey to be a cooperative, unperturbed subject for hematologic study. Additional topics include the role of medication in deriving normal physiologic erythrocellular data, the development of the precursors of the erythrocyte (normoblasts), the morphologic analysis of the megaloblastic series of abnormal erythroid cells, the analysis of erythropoiesis in bone marrow, the relationship of the simian immunodeficiency virus and erythropoiesis, erythrocyte life span, and parasitic invasion of the red cell.
The erythrocyte is perhaps the world's single best known cell, an opinion affirmed by its inseparable linkage with the French expression "Le sang c'est la vie" (i.e., Blood is life). The red cell made its debut in a few invertebrates and thereupon conducted a conceptual phylogenetic odyssey through the Classes of poikilothermic vertebrates, onward to the first homeotherms the avians, and thereafter to the mammals including man. The erythrocyte presents morphologic, cytochemical and quantitative adaptations as it progresses through its evolutionary continuum. The specific objective of this text is to explore in depth the cytology of the erythrocyte in birds. It is intended to derive an understanding of the red cell's diverse aspects as presented among Orders, Families and Genera of avians. Illustrative of the subjects that are explored are the light microscopy and ulrastructure of the maturational sequence of the erythrocyte from proerythroblast to the mature cell, the quantitative representation of the erythroid progenitors in hemopoietic bone marrow, and the relationship of erythropoiesis with the vascular sinuses in the bone marrow. Sections are devoted to the quail-chick chimera and the insight it offers, erythroleukemia, embryologic considerations, primitive and definitive generation erythrocytes, rbc life span, the impact of sporozoan parasitization upon the erythrocellular profile and the morphology associated with pathologic agents and conditions. A major segment of the monograph is a taxonomically organized Table of Erythrogramic Data (primary source-cited, and when derived, indicators of significant differences between sexes, physiologic and experimental conditions).
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