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Erythrocytes of the Rhesus and Cynomolgus Monkeys (Paperback)
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Erythrocytes of the Rhesus and Cynomolgus Monkeys (Paperback)
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Erythrocytes of the Rhesus and Cynomolgus Monkeys addresses the
morphologic, quantitative, and generative aspects of the
erythrocytes of the rhesus monkey Macaca mulatta and the cynomolgus
monkey Macaca fascicularis (long-tailed macaque, crab-eating
monkey). These two species are the most commonly selected nonhuman
primates for basic science and clinical medical investigations. The
hemopoietic cells of man and the rhesus monkey display an intimate
homogeneity. Their functional activities are close and at times
identical. The cynomolgus monkey was enlisted in biomedical studies
at a time when rhesus monkeys were not available in sufficient
quantities. It has gained increased use in the Far East and in the
Western world. It is, for example, employed in the current
development of a vaccine against the deadly Ebola virus. The
authors of the book discuss the erythropoietic profiles of normal
and abnormal macaques of both sexes and of all age groups as
investigated with contemporary electronic methodologies. They cover
the role of stress as it is perceived by the monkey and how it
impacts erythrocellular values, and how to train the monkey to be a
cooperative, unperturbed subject for hematologic study. Additional
topics include the role of medication in deriving normal
physiologic erythrocellular data, the development of the precursors
of the erythrocyte (normoblasts), the morphologic analysis of the
megaloblastic series of abnormal erythroid cells, the analysis of
erythropoiesis in bone marrow, the relationship of the simian
immunodeficiency virus and erythropoiesis, erythrocyte life span,
and parasitic invasion of the red cell.
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