The volume has as primary focus multidimensional gas chromatography (heart-cutting systems, comprehensive 2D-GC systems and hybrid solutions) and its characteristic features for in depth investigation of complex fractions of odor-active volatiles. Contributions, from outstanding researchers in the field from Academia and industry, cover fundamentals aspects on the physiology of olfaction, the strategies to identify key-odorants from the bulk of detectable volatiles (sensomics), the principles of operation of multidimensional analytical platforms (i.e., comprehensive two-dimensional gas chromatography - GCxGC; heart-cut 2D-GC, hybrid systems), and the fundamental role of mass spectrometry in providing reliable and informative data. Insights on new systems design and configurations are also provided, including sample preparation and data processing strategies, as important steps of the whole analytical process. Real-world examples cover food volatiles, complex aroma mixtures, odors emitted from industrial plants, volatiles of interest in forensic and medical applications.

Molecular Nutrition: Mother and Infant presents the impact of diet in early life stages, from pre-conception, throughout pregnancy, and to the infant. The book covers the molecular biology of the cell, genetic machinery and its function, general coverage on diet and nutrition, pregnancy, placenta, weight gain, breast milk, feeding practices, gestational disease, glucose metabolism, immunity, vitamins and minerals. Other topics discusses include fetal programming, bioactive compounds, amino acids, intrauterine growth, one carbon metabolism, overnutrition, genetic risk factors, polymorphisms, folic acid genes, DNA methylation, genes involved in lipid metabolism, microRNAs, epigenetics, transcriptomics and micro RNA. This book will be a welcomed reference for research scientists and practitioners, including nutritionists and dieticians.

This detailed volume explores recent developments in microfluidics technologies for cancer diagnosis and monitoring. The book is divided into two sections that delve into techniques for liquid biopsy for cancer diagnosis and platforms for precision oncology or personalized medicine in order to create effective patient avatars for testing anti-cancer drugs. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.  Authoritative and practical, Microfluidic Systems for Cancer Diagnosis serves as an ideal guide that will be helpful to either replicate the construction of microfluidic devices specifically developed for cancer diagnosis or to catalyze development of new and better cancer diagnostic devices.

El Aguaje Encantado es una novela magico Mexicana que mezcla leyendas y tradiciones de algunos pueblos indigenas Mexicanos, prehispanicos. La ficcion es uno de los argumentos es uno de los argumentos que le da fuerza a la novela de Copal y Fernanda que habiendo nacido el mismo dia y a la misma hora, pero en distintas regiones de Mexico, el tragico destino las junta en la hacienda minera del Aguaje Encantado. Lugar magico, en donde como ninas prodigas crecieron al rededor de la crianza de caballos y estudiando en la gran biblioteca del sotano de la hacienda, en donde con el tiempo descubren la caverna situada debajo dela hacienda, en donde se encontraban prisioneros los Ajawabs de Xibalba, los demonios cosmicos, custodiados por Chack-Mol. AjalkAna y wucubCame los poderosos senores del inframundo y la perversidad universal, han sido liberados por accidente, por las dos bellas videntes y ahora ellos retomaran la labor de devorar todo lo que existe en el sistema solar y sobre todo a la vida organica y la conciencia del ser interno la energia del alma ese es su alimento y lo piensan lograr aunque para eso tengan que destruirlo todo.

Life for a teenage girl in America is hard. That's no exception for Jenna Ella May. This is partly due to the fact that she is shy, plump, and a bit klutzy. The other part, the larger part, is due to the fact that her hated nickname is Chunky. Being a teenage girl is difficult. For Chunky it is a shark-infested ocean of unpredictability.

The story is told through Chunky's eyes. Whether she is being accosted and thrown into a swimming pool by an angry jock, meeting and greeting the new hottie, or stumbling into something or someone; Chunky's life is never dull!

This is a story about self-esteem, self-awareness and self-acceptance. It is told humorously and realistically. Enter into Chunky's world. Relate to her plights, laugh at her bumbles, cry at her tribulations, and cheer at her accomplishments. Simply root for the underdog and you won't be disappointed. This is Chunky's story and the story that thousands of teenage girls the world over will feel they are already living.

The inflammasome is a protein complex composed of an intracellular sensor-typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1 and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1 has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

The legendary Schumacher design house presents an inspiring interiors survey exploring the versatile and transformative use of blue and white Divided by style (charming, modern, boho, traditional, etc.), Schumacher will take you on a tour of the best of blue and white decorating, featuring interiors that show just how versatile this color combination can be. The book features a guide to iconic blue and white colors (from robin’s egg to sky, to cerulean and oyster, to alabaster to porcelain) as well as a roundup of best-in-class product from tabletop to fabrics and wallcoverings.

Cuando el inexperto jesuita, padre Francisco Alvarez, acude al exorcismo de Sara Montalban, en cumplimiento de una orden del Vaticano, nunca penso que se enfrentaria al adversario mas antiguo de la Iglesia Catolica. Semyazza, el primer angel caido y lider de los Grigori habia regresado a la tierra en busca de revancha y del manuscrito perdido del Libro de Enoc. Corria el ano de 1948 cuando todos los pobladores del Barrio de Santa Cruz, en Sevilla, fueron testigos de los sucesos y la perturbacion en la residencia de los Montalban. Sin embargo, nadie se habia atrevido a intervenir en el extrano caso de posesion demoniaca de aquella muchacha y las personas solo comentaban sobre los sucesos extraordinarios de los cuales habian sido testigos, asi como de las manifestaciones preternaturales que rodeaban a toda la ciudad andaluza. Sara Montalban estaba poseida por los demonios mas antiguos conocidos por el hombre, Semyazza y Thaumiel, y solo contaba con la ayuda inhabil de un joven sacerdote, apenas iniciado en la ejecucion del ritual romano. Cuarenta anos despues de aquellos sucesos, los demonios vuelven por el desquite frente a un sacerdote envejecido y acechado por el pasado y los secretos conferidos por su Iglesia. Esta obra es un thriller cuya trama mezcla elementos policiales, de misterio y terror; con el trasfondo y atmosfera de conspiracion e intriga, que envuelven a los mandatos que se hacen desde el Vaticano. En esta novela esos secretos quedan al descubierto y recuerda que el mal convive entre nosotros.

This book provides detailed descriptions of big data solutions for activity detection and forecasting of very large numbers of moving entities spread across large geographical areas. It presents state-of-the-art methods for processing, managing, detecting and predicting trajectories and important events related to moving entities, together with advanced visual analytics methods, over multiple heterogeneous, voluminous, fluctuating and noisy data streams from moving entities, correlating them with data from archived data sources expressing e.g. entities' characteristics, geographical information, mobility patterns, mobility regulations and intentional data. The book is divided into six parts: Part I discusses the motivation and background of mobility forecasting supported by trajectory-oriented analytics, and includes specific problems and challenges in the aviation (air-traffic management) and the maritime domains. Part II focuses on big data quality assessment and processing, and presents novel technologies suitable for mobility analytics components. Next, Part III describes solutions toward processing and managing big spatio-temporal data, particularly enriching data streams and integrating streamed and archival data to provide coherent views of mobility, and storing of integrated mobility data in large distributed knowledge graphs for efficient query-answering. Part IV focuses on mobility analytics methods exploiting (online) processed, synopsized and enriched data streams as well as (offline) integrated, archived mobility data, and highlights future location and trajectory prediction methods, distinguishing between short-term and more challenging long-term predictions. Part V examines how methods addressing data management, data processing and mobility analytics are integrated in big data architectures with distinctive characteristics compared to other known big data paradigmatic architectures. Lastly, Part VI covers important ethical issues that research on mobility analytics should address. Providing novel approaches and methodologies related to mobility detection and forecasting needs based on big data exploration, processing, storage, and analysis, this book will appeal to computer scientists and stakeholders in various application domains.

It isn't that they can't see the solution. It is Approach your problems from the right end and begin with the answers. Then one day, that they can't see the problem perhaps you will find the final question. G. K. Chesterton. The Scandal of Father 'The Hermit Oad in Crane Feathers' in R. Brown 'The point of a Pin'. van Gu ik's The Chillese Maze Murders. Growing specialization and diversification have brought a host of monographs and textbooks on increasingly specialized topics. However, the "tree" of knowledge of mathematics and related fields does not grow only by putting forth new branches. It also happens, quite often in fact, that branches which were thought to be completely disparate are suddenly seen to be related. Further, the kind and level of sophistication of mathematics applied in various sciences has changed drastically in recent years: measure theory is used (non-trivially) in regional and theoretical economics; algebraic geometry interacts with physics; the Minkowsky lemma, coding theory and the structure of water meet one another in packing and covering theory; quantum fields, crystal defects and mathematical programming profit from homotopy theory; Lie algebras are relevant to filtering; and prediction and electrical engineering can use Stein spaces. And in addition to this there are such new emerging subdisciplines as "experimental mathematics," "CFD," "completely integrable systems," "chaos, synergetics and large-scale order," which are almost impossible to fit into the existing classification schemes. They draw upon widely different sections of mathematics.

This edited volume explores the philosophical implications of quantum mechanics. It features papers from venues of the International Ontology Congress (IOC) up to 2016. IOC is a worldwide platform for dialogue and reflection on the interactions between science and philosophy. The collection features philosophers as well as physicists, including David Albert, Harvey Brown, Jeffrey Bub, Otavio Bueno, James Cushing, Steven French, Victor Gomez-Pin, Carl Hoefer, Simon Kochen, Peter Lewis, Tim Maudlin, Peter Mittlestatedt, Roland Omnes, Juha Saatsi, Albert Sole, David Wallace, and Anton Zeilinger. Since the early days of quantum mechanics, philosophers have studied the subject with growing technical skill and fruitfulness. Their efforts have unveiled intellectual bridges between physics and philosophy. These connections have helped fuel the contemporary debate about the scope and limits of realism and understanding in the interpretation of physical theories and scientific theories in general. The philosophical analysis of quantum mechanics is now one of the most sophisticated and productive areas in contemporary philosophy, as the papers in this collection illustrate.

Sugar was the single most valuable bulk commodity traded internationally before oil became the world's prime resource. From the sixteenth to the eighteenth century, cane sugar production was pre-eminent in the Atlantic Islands, the Caribbean, and Brazil. Subsequently, cane sugar industries in the Americas were transformed by a fusion of new and old forces of production, as the international sugar economy incorporated production areas in Asia, the Pacific, and Africa. Sugar's global economic importance and its intimate relationship with colonialism offer an important context for probing the nature of colonial societies. This book questions some major assumptions about the nexus between sugar production and colonial societies in the Caribbean and Southeast Asia, especially in the second (post-1800) colonial era.

The present volume gathers contributions to the conference Microlocal and Time-Frequency Analysis 2018 (MLTFA18), which was held at Torino University from the 2nd to the 6th of July 2018. The event was organized in honor of Professor Luigi Rodino on the occasion of his 70th birthday. The conference's focus and the contents of the papers reflect Luigi's various research interests in the course of his long and extremely prolific career at Torino University.

This authoritative text studies pseudodifferential and Fourier integral operators in the framework of time-frequency analysis, providing an elementary approach, along with applications to almost diagonalization of such operators and to the sparsity of their Gabor representations. Moreover, Gabor frames and modulation spaces are employed to study dispersive equations such as the Schroedinger, wave, and heat equations and related Strichartz problems. The first part of the book is addressed to non-experts, presenting the basics of time-frequency analysis: short time Fourier transform, Wigner distribution and other representations, function spaces and frames theory, and it can be read independently as a short text-book on this topic from graduate and under-graduate students, or scholars in other disciplines.