Inflammasomes: Clinical and Therapeutic Implications (Hardcover, 1st ed. 2018)

The inflammasome is a protein complex composed of an intracellular sensor-typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1 and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1 has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Experientia Supplementum, 108
Release date:	September 2018
First published:	2018
Editors:	Mario D. Cordero • Elisabet Alcocer-Gomez
Dimensions:	235 x 155mm (L x W)
Format:	Hardcover
Pages:	400
Edition:	1st ed. 2018
ISBN-13:	978-3-319-89389-1
Categories:	Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	3-319-89389-0
Barcode:	9783319893891

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