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Parameters such as membrane transport, metabolism and protein
incorporation govern the fate of amino acids in living tissue. Is
it possible to use positron tomography to measure some of them, and
what is their meaning in normal and pathological situations? These
questions have been addressed for a long time and no satisfactory
answer has yet been given. This book, which derives from an EEC
workshop organized in the frame of the Concerted Action on PET
Investigation of Cellular Regeneration and Degeneration', held in
Lyon in February 1992, gives the present state of knowledge in this
field based on the most recent studies. Contributions from 24
leading European and American scientists are presented and
discussed in the following four parts: biochemistry and animal
studies; amino acids labelling with positron emittors, quality
control and metabolites measurement; kinetic modelling of amino
acids transport, metabolism, and protein incorporation; clinical
use of amino acids. This book will aid and interest biochemists,
radiochemists, pharmacologists, neurologists, oncologists and
medical imaging scientists.
Imaging of the Dopaminergic system in the human brain with the in
vivo use of Positron Emis- sion Tomography has emerged in the late
1980s as a tool of major importance in Clinical Neuros- ciences and
Pharmacology. The last few years have witnessed the rapid
development of new radiotracers specific to receptors, reuptake
sites and enzymes of the dopamine system; the application of these
radiotracers has led to major breakthroughs in the pathophysiology
and therapy of movement disorders and schizophrenic-like psychoses.
This book is the first to collect, in a single volume,
state-of-the-art contributions to the various aspects of this
research. Its contents address methodological issues related to the
design, labelling, quantitative imaging and compartmental
modelisation of radioligands of the post-synaptic, pre-synaptic and
enzyme sites of the dopamine system and to their use in clinical
research in the fields of Parkinson's disease as well as other
movement disorders, psychoses and neuroleptic receptor occupancy.
The chapters were written by leading European scientists in the
field of Positron Emission Tomography, gathered together in Caen
(France, November 1990) under the aegis of the EEC Concerted Action
on "PET Investigations of Cellular Regeneration and Degeneration.
This book provides a current and comprehensive overview on PET
studies of the brain dopamine system which should aid and interest
neurologists, psychiatrists, pharmacologists and medical imaging
scientists. J. C. Baron D. Comar L. Farde J. L. Martinot B. Mazoyer
August 1991 ix LIST OF CONTRffiUTORS Dr Yves Agid DrL.
Can drug development and evaluation be improved by the use of
positron emission tomography (PET)? PET is now well established and
many PET centres participate in networks that warrant the quality
of their research. PET allows one to follow the effect of a drug on
a variety of patients' metabolic parameters. In addition, PET may
be used to follow the fate in vivo of a compound, allowing
visualisation of its binding to specific receptors and a direct
study of the mechanism of drug action in normal and pathological
situations. The book shows the fields in which PET offers new and
unique information for the development of drugs (conception,
toxicity, pharmacokinetics and metabolism, clinical research, and
relations between clinical and biological effects) and evaluates
fields in which PET may shorten the development time of drugs.
Audience: Professionals in the pharmaceutical industry in all areas
of drug discovery and pharmacology, pre-clinical testing,
pharmacokinetics and metabolism, clinical evaluation, registration
and regulatory affairs. Government health authority representatives
who assess data and documentation on new drug development and
radiopharmaceuticals. Academic experts concerned with any of these
areas.
Can drug development and evaluation be improved by the use of
positron emission tomography (PET)? PET is now well established and
many PET centres participate in networks that warrant the quality
of their research. PET allows one to follow the effect of a drug on
a variety of patients' metabolic parameters. In addition, PET may
be used to follow the fate in vivo of a compound, allowing
visualisation of its binding to specific receptors and a direct
study of the mechanism of drug action in normal and pathological
situations. The book shows the fields in which PET offers new and
unique information for the development of drugs (conception,
toxicity, pharmacokinetics and metabolism, clinical research, and
relations between clinical and biological effects) and evaluates
fields in which PET may shorten the development time of drugs.
Audience: Professionals in the pharmaceutical industry in all areas
of drug discovery and pharmacology, pre-clinical testing,
pharmacokinetics and metabolism, clinical evaluation, registration
and regulatory affairs. Government health authority representatives
who assess data and documentation on new drug development and
radiopharmaceuticals. Academic experts concerned with any of these
areas.
Parameters such as membrane transport, metabolism and protein
incorporation govern the fate of amino acids in living tissue. Is
it possible to use positron tomography to measure some of them, and
what is their meaning in normal and pathological situations? These
questions have been addressed for a long time and no satisfactory
answer has yet been given. This book, which derives from an EEC
workshop organized in the frame of the Concerted Action on "PET
Investigation of Cellular Regeneration and Degeneration", held in
Lyon in February 1992, gives the present state of knowledge in this
field based on the most recent studies. Contributions from 24
leading European and American scientists are presented and
discussed.
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