The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and safety-related market withdrawal rates today as it did 20 years ago. Industrialization of Drug Discovery: From Target Selection Through Lead Optimization scrutinizes these problems in detail, contrasting the promise of technology and industrialization with the challenges of using the tools available to their best advantage. The book explores early successes, examines the current state of the art, and provides a strategic analysis of the issues currently facing drug discovery. Introducing the historical background and current status of the industry, the book delineates the basic tenets underlying modern drug discovery, how they have evolved, and their use in various approaches and strategies. It examines, in detail, the regulations, requirements, guidelines, and draft documents that guide so many FDA actions. The editor devotes the remainder of the discussion to industrialization, compound and knowledge management functions, the drug screening process, collaboration, and finally, ethical issues. Drawing on real-life, from-the-trenches examples, the book elucidates a new approach to drug discovery and development. This modern-day, back-to-basics approach includes three steps: understand the science, unravel the story, and then intelligently apply the technology, bringing to bear the entire armamentarium of industrialization techniques, not just automation, to the discovery process. Using these steps, you can meet the goals of more specific targets, more selective compounds, and decreased cycle times. In effect, you can look for a bigger needle in a smaller haystack. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

The shape and course which Christian thought has taken over its history is largely due to the contributions of individuals and communities in the second and third centuries. Bringing together a remarkable team of distinguished scholars, The Routledge Companion to Early Christian Thought is the ideal companion for those seeking to understand the way in which Early Christian thought developed within its broader cultural milieu and was communicated through its literature, especially as it was directed toward theological concerns.

Divided into three parts, the Companion

• asks how Christianity's development was impacted by its interaction with cultural, philosophical, and religious elements within the broader context of the second and third centuries.
• examines the way in which Early Christian thought was manifest in key individuals and literature in these centuries.
• analyses Early Christian thought as it was directed toward theological concerns such as God, Christ, Redemption, Scripture, and the community and its worship.

Jeffreys explores the spiritual consequences and ethics of modern solitary confinement and emphasizes how solitary confinement damages our spiritual lives. He focuses particularly on how it destroys one's relationship to time and undermines our creativity, and proposes institutional changes in order to mitigate profound damage to prisoners.

Spirituality in Dark Places explores the spiritual consequences and ethics of modern solitary confinement. Jeffreys emphasizes how solitary confinement damages our spiritual lives, focusing particularly on how it destroys our relationship to time and undermines our creativity. Solitary inmates experience profound temporal dislocation that erodes their personal identities. They are often isolated from music, art, and books, or find their creativity tightly controlled. Informed by experiences with inmates, chaplains, and employees in the Wisconsin Department of Corrections, Jeffreys also evaluates the ethics of solitary confinement, considering but ultimately rejecting the argument that punitive isolation justifiably expresses moral outrage at heinous crimes. Finally, Jeffreys proposes changes in solitary confinement in order to mitigate its profound damage to both prisoners and human dignity at large.

This book shows how torture spiritually assaults the person. The "war on terror" has sparked great debate about torture. What exactly is torture? Should we torture suspected terrorists if they have information about future violent acts? Defining torture carefully, the book defends the idea that all people are valuable, and rejects moral defenses of torture. It focuses particularly on practices like sensory deprivation, which perniciously attack the human psyche. It also calls for an absolute ban on all torture, and urges Americans to repent for the torture the U.S. committed in the "war on terror."

The study of human bipedalism has been overshadowed by many polarized debates. One dispute concerns whether or not australopithecines were wholly terrestrial or retained a degree of arboreality. Another deliberation focuses on the bipedalism of australopithecines compared to modern humans: was it similar, intermediate in nature, or unique? Because of the preoccupation with discussions such as these, the significant fact that modern human walking is more than locomotion on two legs has been underemphasized.
This volume focuses on the pattern and process of the transition to the modern form of human locomotion, with its adaptations for a striding stiff-legged gait, efficiency of running, and economy of resource transport. This emerging group of contributors spanning the fields of anthropology, biology and anatomy debate issues such as:
-When and in what sequence did these morphological traits appear?
-What were the changes in the bio-behavioral complex of hominin locomotor evolution?
-What were the implications for the enhancement and expansion of hominin mobility?

The study of human bipedalism has been overshadowed by many polarized debates. One dispute concerns whether or not australopithecines were wholly terrestrial or retained a degree of arboreality. Another deliberation focuses on the bipedalism of australopithecines compared to modern humans: was it similar, intermediate in nature, or unique? Because of the preoccupation with discussions such as these, the significant fact that modern human walking is more than locomotion on two legs has been underemphasized.
This volume focuses on the pattern and process of the transition to the modern form of human locomotion, with its adaptations for a striding stiff-legged gait, efficiency of running, and economy of resource transport. This emerging group of contributors spanning the fields of anthropology, biology and anatomy debate issues such as:
-When and in what sequence did these morphological traits appear?
-What were the changes in the bio-behavioral complex of hominin locomotor evolution?
-What were the implications for the enhancement and expansion of hominin mobility?

Portrait of Deadly Excess is a work of literary suspense tracing a volatile investigator's descent into a stark world of ulterior motives and twisted obsessions-not all of which are his own. At the center of the action is Van Hazard-a freelance insurance investigator specializing in claims involving lost and stolen art. Hazard, a former NYPD detective and an established artist in his own right, is a man at war with himself and a flawed world he largely disproves of. Half white, half black, refusing to deny one part of himself in order to lose himself in the other, Hazard is the consummate outsider with equal claim to two different worlds but at home in neither one. He's a stylish, resourceful loner whose wry wit and warped sense of humor almost obscures the haunted avenger within. Hazard is shaken when he loses two close friends to a mysterious fire he was too late on the scene to prevent. He's intrigued, however, by the tale told by the lone survivor-a stranger he pulled from the flames-that a picture of a dead man came to life and committed murder. Hazard puts his career and reputation on the line to unravel the case and discover the truth, and soon descends into an ever-shifting landscape of duplicity and deception as he struggles to come to terms with a famous painter's quest to cheat death and justice with his art. Portrait of Deadly Excess is a brooding tale in which the immovable object of a formidable, sometimes reckless investigator determined to settle the books on a string of bizarre murders is matched against the irresistible force of a celebrated artist intoxicated with the strange power of his art. Hazard's character is an edgy cross between Chandler's resourceful Philip Marlowe and Conrad's haunted Kurtz, and is in relentless pursuit of a charismatic painter equal parts Warhol, Faust, and Dorian Gray obsessed with giving new meaning to achieving immortality through one's art.

Portrait of Deadly Excess is a work of literary suspense tracing a volatile investigator's descent into a stark world of ulterior motives and twisted obsessions-not all of which are his own. At the center of the action is Van Hazard-a freelance insurance investigator specializing in claims involving lost and stolen art. Hazard, a former NYPD detective and an established artist in his own right, is a man at war with himself and a flawed world he largely disproves of. Half white, half black, refusing to deny one part of himself in order to lose himself in the other, Hazard is the consummate outsider with equal claim to two different worlds but at home in neither one. He's a stylish, resourceful loner whose wry wit and warped sense of humor almost obscures the haunted avenger within. Hazard is shaken when he loses two close friends to a mysterious fire he was too late on the scene to prevent. He's intrigued, however, by the tale told by the lone survivor-a stranger he pulled from the flames-that a picture of a dead man came to life and committed murder. Hazard puts his career and reputation on the line to unravel the case and discover the truth, and soon descends into an ever-shifting landscape of duplicity and deception as he struggles to come to terms with a famous painter's quest to cheat death and justice with his art. Portrait of Deadly Excess is a brooding tale in which the immovable object of a formidable, sometimes reckless investigator determined to settle the books on a string of bizarre murders is matched against the irresistible force of a celebrated artist intoxicated with the strange power of his art. Hazard's character is an edgy cross between Chandler's resourceful Philip Marlowe and Conrad's haunted Kurtz, and is in relentless pursuit of a charismatic painter equal parts Warhol, Faust, and Dorian Gray obsessed with giving new meaning to achieving immortality through one's art.

Have you ever watched an inappropriately rated movie with children and later regretted it? As hosts of the weekly radio review show and authors of "Frame by Frame: 2006-A Family-Friendly Guide to the Movies ," Dr. Rus and Sandra Jeffrey cut through the Hollywood hype to offer concise, easy-to-read movie reviews designed with families in mind.

In addition to movie reviews, you'll also find a more complete analysis of what they cover on the radio each week. Some movies they "tank," an expression they use when they trash a movie-but that doesn't mean they can't find any redeeming factors. As a result, the couple discusses all aspects of each movie, focusing on the positive and negative elements. Most importantly, the Jeffreys encourage families to watch movies together, and they provide discussion starters so the entire family can talk about what they have just watched.

Whether renting movies online or at the local video store, "Frame by Frame" helps families select movies with the certainty they won't be blindsided by inappropriate content. With its simple rating system, straightforward reviews, and a quick-flip reference guide, "Frame by Frame" provides the resources you need right at your fingertips.

Read and listen to reviews online at www.DrRus.com.

How does the Book of Mormon, keystone of the LDS faith, stand up to data abut DNA sequencing that puts the ancestors of modern Native Americans in northeast Asia instead of Palestine? In Who Are the Children of Lehi? Meldrum and Stephens examine the merits and the fallacies of DNA-based interpretations that challenge the Book of Mormon's historicity. They provide clear guides to the science, summarize the studies, illuminate technical points with easy-to-grasp examples, and spell out the data's implications.

The story of Christianity is a fascinating tale. Here we find drama, vision and expansion along with failure, setbacks and tragedy. Yet during the past two thousand years the power of Jesus is felt throughout the interplay of human actors and the forces of world events. How can you grasp the story played out on such a gigantic stage? This book is an ideal place to start. D. Jeffrey Bingham has skillfully selected the key people and episodes to tell a grand and humbling story. From Roman persecution to the early creeds, from the monastic movement to the Reformation, from the rise of liberalism to missionary expansion, he chronicles the ups and downs of a people and a faith. This pocket history has been crafted for students, pastors and other busy people who want an informed, clear and concise presentation that feeds the mind and moves the heart. It is an account that nurtures the Christian virtues of faith, hope and love. For Bingham aims not only to uncover the treasures of the church's past but also to show how history aids your own spiritual journey today. Designed for students and pastors alike, the short and accessible volumes in the IVP Pocket Reference Series will help you tackle the study of biblical languages, church history, apologetics, world religions, Christian spirituality, ethics, theology, and more.

The drug discovery and development process is getting longer, more expensive, and no better. The industry suffers from the same clinical attrition and safety-related market withdrawal rates today as it did 20 years ago. Industrialization of Drug Discovery: From Target Selection Through Lead Optimization scrutinizes these problems in detail, contrasting the promise of technology and industrialization with the challenges of using the tools available to their best advantage. The book explores early successes, examines the current state of the art, and provides a strategic analysis of the issues currently facing drug discovery. Introducing the historical background and current status of the industry, the book delineates the basic tenets underlying modern drug discovery, how they have evolved, and their use in various approaches and strategies. It examines, in detail, the regulations, requirements, guidelines, and draft documents that guide so many FDA actions. The editor devotes the remainder of the discussion to industrialization, compound and knowledge management functions, the drug screening process, collaboration, and finally, ethical issues. Drawing on real-life, from-the-trenches examples, the book elucidates a new approach to drug discovery and development. This modern-day, back-to-basics approach includes three steps: understand the science, unravel the story, and then intelligently apply the technology, bringing to bear the entire armamentarium of industrialization techniques, not just automation, to the discovery process. Using these steps, you can meet the goals of more specific targets, more selective compounds, and decreased cycle times. In effect, you can look for a bigger needle in a smaller haystack. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.