The drug discovery and development process is getting longer, more
expensive, and no better. The industry suffers from the same
clinical attrition and safety-related market withdrawal rates today
as it did 20 years ago. Industrialization of Drug Discovery: From
Target Selection Through Lead Optimization scrutinizes these
problems in detail, contrasting the promise of technology and
industrialization with the challenges of using the tools available
to their best advantage. The book explores early successes,
examines the current state of the art, and provides a strategic
analysis of the issues currently facing drug discovery. Introducing
the historical background and current status of the industry, the
book delineates the basic tenets underlying modern drug discovery,
how they have evolved, and their use in various approaches and
strategies. It examines, in detail, the regulations, requirements,
guidelines, and draft documents that guide so many FDA actions. The
editor devotes the remainder of the discussion to
industrialization, compound and knowledge management functions, the
drug screening process, collaboration, and finally, ethical issues.
Drawing on real-life, from-the-trenches examples, the book
elucidates a new approach to drug discovery and development. This
modern-day, back-to-basics approach includes three steps:
understand the science, unravel the story, and then intelligently
apply the technology, bringing to bear the entire armamentarium of
industrialization techniques, not just automation, to the discovery
process. Using these steps, you can meet the goals of more specific
targets, more selective compounds, and decreased cycle times. In
effect, you can look for a bigger needle in a smaller haystack.
Daniel E. Levy, editor of the Drug Discovery Series, is the founder
of DEL BioPharma, a consulting service for drug discovery programs.
He also maintains a blog that explores organic chemistry.
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