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Aquaporins, Volume 51 (Hardcover)
Dale J. Benos, Sidney A. Simon; Volume editing by Stefan Hohmann, Peter Agre, Soren Nielsen
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R4,599
Discovery Miles 45 990
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Ships in 12 - 17 working days
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Aquaporins summarizes the present knowledge in this expanding field
of research, starting with the structural analysis of water channel
proteins. Subsequent chapters begin with mammalian aquaporins,
examining physiology and pathophysiology, analysis of knock-out
model animals, and the regulation of aquaporin function. Also
covered is the distribution and regulation of aquaporins in plants
and the function of water and glycerol channels in microbial
systems.
Key Features
* Comprehensive treatment of a topical research field
* Authored by world leaders in the field
* Covers structural biology and physiology
* Covers different experimental and biological systems
* Chapters on plant and microbial systems
* Extensive treatment of mammalian physiology and
pathophysiology
* Structural analysis excellently illustrated
DESCRIPTION:
Current Topics in Membranes provides a systematic, comprehensive,
and rigorous approach to specific topics relevant to the study of
cellular membranes. Each volume is a guest edited compendium of
membrane biology. Articles in this volume discuss ion
transport;
ocular aquaporins and aqueous humor dynamics;
the role of Ggap junction channels in the ciliary body secretory
epithelium; regional dependence of inflow; functional modulators
linking Iinflow with outflow of aqueous humor; aqueous humor
outflow resistance; aqueous humor dynamics; the effects of
circulatory events on
aqueous humor inflow and intraocular pressure; retinal ganglion
cells and glaucoma; what functional genomics is teaching us about
intraocular pressure regulation and glaucoma;
molecular approaches to glaucoma; outflow signaling mechanisms and
new therapeutic strategies for the control of intraocular pressure.
*Guest edited by cell membrane experts
*Dynamic and thorough coverage of all aspects of the aqueous humor
from inflow to outflow
*Provides the latest teachings on genomics and glaucoma
*Highlights new therapeutic strategies for the control of
intraocular pressure
"Current Topics in Membranes" provides a systematic, comprehensive,
and rigorous approach to specific topics relevant to the study of
cellular membranes. Each volume is a guest edited compendium of
membrane biology.
*Discusses the current stat of electrostatics in biomolecular
simulations and future directions
*Includes information on time and length scales in lipid bilayer
simulations
*Includes a chapter on the nature of lipid rafts
Membranes are essential cellular organelles. They not only define
cells and other organelles, but also are critical in the cell
function by selectively regulating the passage of molecules by
acting as a matrix for other signaling molecules, and as conduits
of information transfer between the external environment and the
cell interior. This series was originally added in 1970 and has
since provided a systematic, comprehensive, and rigorous approach
to specific topics relevant to the study of cellular membranes.
Each volume is a guest edited compendium of membrane biology. This
series has been a mainstay for practicing scientists and students
interested in this critical field of biology. Articles covered in
the volume include The Mechanical Properties of Bilayers; Molecular
Dynamic Modeling of MS Channels; Structures of the Prokaryotic
Mechanosensitive; Channels MscL and MscS; 3.5 Billion Years of
Mechanosensory Transduction: Structure and Function of
Mechanosensitive Channels in Prokaryotes; Activation of
Mechanosensitive Ion Channels by Forces Transmitted through
Integrins and the Cytoskeleton; Thermodynamics of
Mechanosensitivity; Flexoelectricity and Mechanotransduction; Lipid
Effects on Mechanosensitive Channels; Functional Interactions of
the Extracellular Matrix with Mechanosensitive Channels; MSCL: The
Bacterial Mechanosensitive Channel of Large Conductance; The
Bacterial Mechanosensitive Channel MscS: Emerging Principles of
Gating and Modulation; Structure function relations of MscS; The
MscS Cytoplasmic Domain and its Conformational Changes upon the
Channel Gating; Microbial TRP Channels and Their
Mechanosensitivity; MSCS-Like Proteins in Plants; Delivering Force
and AmplifyingSignals in Plant Mechanosensing; MS Channels in Tip
Growing Systems.
Current Topics in Membranes provides a systematic, comprehensive,
and rigorous approach to specific topics relevant to the study of
cellular membranes. Each volume is a guest edited compendium of
membrane biology. This series has been a mainstay for practicing
scientists and students interested in this critical field of
biology. Articles covered in the volume include ENaC Proteins in
Vascular Smooth Muscle Mechanotransduction; Regulation of the
Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids;
MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion
Channels as a Potential Mechanosensory Mechanism. Lessons From
Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of
Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic
Interplay between Structure and Function; Pharmacology of Hair Cell
MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell
Mechanotrasduction; Touch; Mechanosensitive Ion Channels in
Dystrophic Muscle; Mechanotransduction in Endothelial Cells;
MS Channels in Tumor Cell Migration; Mechanosensitive Channels in
Regulating Smooth Muscle Contraction in the GI; Mechanosensitive
Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.
This volume in the "Current Topics in Membranes" series discusses
the biology of chemokines and their binding partners, chemokine
receptors, in normal and disease-related states. Chemokines are
small proteins that are important in normal immune responses.
Recent research demonstrates a role for these proteins in a variety
of diseases such as heart disease, allergy, asthma, and cancer. As
a result of the discovery of this link to disease, the topic of
chemokines and drugs that block their actions has become an intense
are of study. This book presents the topics of chemokines,
chemokine receptors, and related pathologies in an integrated
manner that provides the reader with a comprehensive and up-to-date
knowledge of these topics.
* Provides a comprehensive overview of the history, molecular
biology, cell biology, pharmacology, physiology, and
pathophysiology of chemokines and their receptors
* Each chapter discusses "future directions and unanswered
questions" of chemokine biology
* Serves as a road map for future research
Since the first gap junction protein (connexin) was cloned over a
decade ago, more than a dozen connexin genes have been cloned.
Consequently, a wealth of information on the molecular basis of gap
junctional communication has been accumulated. This book pays
tribute to this exciting era in the history of cell communication
research by documenting the great strides made in this field as a
result of the merging of biophysics and molecular biology, two of
the most powerful approaches to studying the molecular basis of
membrane channel behavior. Twenty-eight comprehensive chapters,
authored by internationally recognized leaders in the field,
discuss the biophysical, physiological, and molecular
characteristics of cell-to-cell communication via gap junctions.
Key aspects of molecular structure, formation, gating, conductance,
and permeability of vertebrate and invertebrate gap junction
channels are highlighted. In addition, a number of chapters focus
on recent discoveries that implicate connexin mutations and
alterations of gap junctional communication in the pathogenesis of
several diseases, including the X-linked Charcot-Marie-Tooth
demyelinating disease, some forms of inherited sensorineural
deafness, malignant transformation, cardiac malformations and
arrhythmia, eye lens cataract, and Chagas disease.
Sodium reabsorbing epithelia play a major role in whole-body sodium
homeostasis. Some examples of sodium regulating tissues include
kidney, colon, lung, and sweat ducts. Sodium transport across these
membranes is a two-step process: entry through an
amiloride-sensitive sodium channel and exit via the
ouabain-sensitive sodium/potassium ATPase. The sodium entry
channels are the rate-limiting determinant for transport and are
regulated by several different hormones. The sodium channels also
play a significant role in a number of disease states, like
hypertension, edema, drug-induced hyperkalemia, and cystic
fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and
Functional Diversity provides the first in-depth exchange of ideas
concerning these sodium channels, their regulation and involvement
in normal and pathophysiological situations.
Key Features
* Summarizes current state of amiloride-sensitive sodium channel
field
* Analyzes structure-function of epithelial sodium channels
* Discusses immunolocalization of epithelial sodium channels
* Examines hormonal regulation of sodium channels
* Discusses sodium channels in lymphocytes, kidney, and lung
* Considers mechanosensitivity of sodium channels
* Provides ideas on sodium channels and disease
Challenging and provocative overviews are presented in Volume 40 of
Current Topics in Membranes. Topics on cell lipids vary from basic
themes such as biosynthesis and membrane distribution to the role
of lipids in intracellular signaling and membrane flow. This single
volume also highlights the roles of lipids in eukaryotic cells and
discusses organization of lipids in microdomains.
Membrane permeability is fundamental to all cell biology and
subcellular biology. The cell exists as a closed unit. Import and
export depend upon a number of sophisticated mechanisms, such as
active transport, endocytosis, exocytosis, and passive diffusion.
These systems are critical for the normal housekeeping
physiological functions. However, access to the cell is also taken
advantage of by toxic microbes (such as cholera or ptomaine) and
when designing drugs.
Ernest Overton, one of the pioneers in lipid membrane research, put
forward the first comprehensive theory of lipid membrane structure.
His most quoted paper on the osmotic properties of cells laid the
foundation for the modern concepts of membrane function, most
notably important in anesthesia.
This book is designed to celebrate the centennial anniversary (in
the first chapter) of Overton's work. Subsequent chapters present
readers with up-to-date concepts of membrane structure and function
and the challenge they pose for new explorations.
Key Features
* Provides an historical perspective of Overton's contributions to
the theory of narcosis
* Presents an overview of each permeability mechanism, including
active transport, endocytosis, exocytosis, and passive diffusion
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