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This book provides comprehensive information, both for clinicians
and scientists, on the basic mechanisms, clinical features, and
therapeutic approaches to epilepsy as an inflammatory disease.
Inflammation has been for many years considered as an etiologic
player (and a therapeutic target) for a specific group of
epilepsies. However, it turns out that this concept underestimated
the impact of inflammation in seizure disorders. Many accepted
therapies for non-inflammatory epilepsies act in part as an
inflammatory drug. The CNS actively responds to acute immune
challenges by altering body temperature, stimulating the HPA axis,
as well as up- and down-regulating specific sympathetic pathways.
This book provides comprehensive information, both for clinicians
and scientists, on the basic mechanisms, clinical features, and
therapeutic approaches to epilepsy as an inflammatory disease.
Inflammation has been for many years considered as an etiologic
player (and a therapeutic target) for a specific group of
epilepsies. However, it turns out that this concept underestimated
the impact of inflammation in seizure disorders. Many accepted
therapies for non-inflammatory epilepsies act in part as an
inflammatory drug. The CNS actively responds to acute immune
challenges by altering body temperature, stimulating the HPA axis,
as well as up- and down-regulating specific sympathetic pathways.
Cell Cycle in the Central Nervous System overviews the changes in
cell cycle as they relate to prenatal and post natal brain
development, progression to neurological disease or tumor
formation.Topics covered range from the cell cycle during the
prenatal development of the mammalian central nervous system to
future directions in postnatal neurogenesis through gene transfer,
electrical stimulation, and stem cell introduction. Additional
chapters examine the postnatal development of neurons and glia, the
regulation of cell cycle in glia, and how that regulation may fail
in pretumor conditions or following a nonneoplastic CNS response to
injury. Highlights include treatments of the effects of deep brain
stimulation on brain development and repair; the connection between
the electrophysiological properties of neuroglia, cell cycle, and
tumor progression; and the varied immunological responses and their
regulation by cell cycle.
Denis Noble Nearly a decade after completion of the first draft of
the entire Human Genome sequence we are in a better position to
assess the nature and the consequences of that heroic achievement,
which can be seen as the culmination of the molecular biological
revolution of the second half of the twentieth century. The
achievement itself was celebrated at the highest levels (President
and Prime Minister) on both sides of the Atlantic, and rightly so.
DNA sequencing has become sufficiently c- mon now, even to the
extent of being used in law courts, that it is easy to forget how
technically difficult it was and how cleverly the sequencing teams
solved those problems in the exciting race to finish by the turn of
the century [1, 2]. The fanfares were misplaced, however, in an
important respect. The metaphors used to describe the project and
its biological significance gave the impression to the public at
large, and to many scientists themselves, that this sequence would
reveal the secrets of life. DNA had already been likened to a
computer program [3]. The "genetic program" for life was therefore
to be found in those sequences: A kind of map that had simply to be
unfolded during development. The even more colo- ful "book of life"
metaphor gave the promise that reading that book would lead to a
veritable outpouring of new cures for diseases, hundreds of new
drug targets, and a brave new world of medicine.
Denis Noble Nearly a decade after completion of the first draft of
the entire Human Genome sequence we are in a better position to
assess the nature and the consequences of that heroic achievement,
which can be seen as the culmination of the molecular biological
revolution of the second half of the twentieth century. The
achievement itself was celebrated at the highest levels (President
and Prime Minister) on both sides of the Atlantic, and rightly so.
DNA sequencing has become sufficiently c- mon now, even to the
extent of being used in law courts, that it is easy to forget how
technically difficult it was and how cleverly the sequencing teams
solved those problems in the exciting race to finish by the turn of
the century [1, 2]. The fanfares were misplaced, however, in an
important respect. The metaphors used to describe the project and
its biological significance gave the impression to the public at
large, and to many scientists themselves, that this sequence would
reveal the secrets of life. DNA had already been likened to a
computer program [3]. The "genetic program" for life was therefore
to be found in those sequences: A kind of map that had simply to be
unfolded during development. The even more colo- ful "book of life"
metaphor gave the promise that reading that book would lead to a
veritable outpouring of new cures for diseases, hundreds of new
drug targets, and a brave new world of medicine.
Cell Cycle in the Central Nervous System overviews the changes in
cell cycle as they relate to prenatal and post natal brain
development, progression to neurological disease or tumor
formation.Topics covered range from the cell cycle during the
prenatal development of the mammalian central nervous system to
future directions in postnatal neurogenesis through gene transfer,
electrical stimulation, and stem cell introduction. Additional
chapters examine the postnatal development of neurons and glia, the
regulation of cell cycle in glia, and how that regulation may fail
in pretumor conditions or following a nonneoplastic CNS response to
injury. Highlights include treatments of the effects of deep brain
stimulation on brain development and repair; the connection between
the electrophysiological properties of neuroglia, cell cycle, and
tumor progression; and the varied immunological responses and their
regulation by cell cycle.
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