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The triggered release of functional compounds from such polymeric
carriers as micelles, nanoparticles or nanogels is a rapidly
developing and highly versatile concept which is expected to be one
of the key approaches to future therapeutics. In his thesis, Daniel
Klinger highlights the approach of stimuli-responsive microgels for
such applications and discusses why especially light as a trigger
has an outstanding position amongst the family of conventional
stimuli. Based on these considerations, the author focuses on the
design, synthesis and characterization of novel photo-sensitive
microgels and nanoparticles as potential materials for the loading
and light-triggered release/accessibility of functional compounds.
Starting from the synthesis of photo-cleavable organic building
blocks and their use in the preparation of polymeric nanoparticles,
continuing to the examination of their loading and release
profiles, and concluding with biological in vitro studies of the
final materials, Daniel Klinger's work is an excellent example of
the multidisciplinary research needed for the successful
development of new materials in this field and has led to a number
of further publications in internationally respected journals.
The triggered release of functional compounds from such polymeric
carriers as micelles, nanoparticles or nanogels is a rapidly
developing and highly versatile concept which is expected to be one
of the key approaches to future therapeutics. In his thesis, Daniel
Klinger highlights the approach of stimuli-responsive microgels for
such applications and discusses why especially light as a trigger
has an outstanding position amongst the family of conventional
stimuli. Based on these considerations, the author focuses on the
design, synthesis and characterization of novel photo-sensitive
microgels and nanoparticles as potential materials for the loading
and light-triggered release/accessibility of functional compounds.
Starting from the synthesis of photo-cleavable organic building
blocks and their use in the preparation of polymeric nanoparticles,
continuing to the examination of their loading and release
profiles, and concluding with biological in vitro studies of the
final materials, Daniel Klinger's work is an excellent example of
the multidisciplinary research needed for the successful
development of new materials in this field and has led to a number
of further publications in internationally respected journals.
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